母猪繁殖障碍综合征的主要发病原因及机制研究进展

doi:10.11843/j.issn.0366-6964.2023.08.002

Abstract

Abstract: Sow reproductive disorder is one of the important factors that restrict the development of Chinese pig industry. It can cause abnormal estrus, repeated infertility, abortion stillbirth, mummified fetus and weak fetus, which leads to the prolongation of sow breeding cycle, the decrease of live (healthy) litter size and the shortening of service life, and seriously affects the economic benefits. Sow reproductive disorder syndrome (SRDS) is affected by many factors such as genetics, functional disorders, environment, nutrition and disease. This paper has reviewed recent studies on the causes, pathogenesis and prevention measures of SRDS. In order to provide new ideas and reference for prevention and control of sow reproductive disorder.

Key words: sow, reproductive disorders, pathogenesis, control measures

CLC Number:

S858.28

HE Chenpeng, LI Baizhen, LIU Jie, HE Jianhua, WU Shusong. Research Progress on Main Causes and Mechanism of Sow Reproductive Disorder Syndrome[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3139-3151.

References 101

[1]	陈斌.遗传原因造成种猪繁殖障碍的综合分析[J].猪业科学, 2014, 31(6):46-48.CHEN B.Comprehensive analysis of genetic causes causing reproductive obstacles in breeding pigs[J].Swine Industry Science, 2014, 31(6):46-48.(in Chinese)
[2]	杨利国.动物繁殖学[M].3版.北京:中国农业出版社, 2019:225-226.YANG L G.Animal reproduction[M].3rd ed.Beijing:China Agriculture Press, 2019:225-226.(in Chinese)
[3]	ŚWITOŃSKI M, JACKOWIAK H, GODYNICKI S, et al.Familial occurrence of pig intersexes (38, XX; SRY-negative) on a commercial fattening farm[J].Anim Reprod Sci, 2002, 69(1-2):117-124.
[4]	WANG H T, CHEN L, JIANG Y W, et al.Association of gene polymorphisms of estrogen receptor, follicle-stimulating hormone β and leptin with follicular cysts in Large White sows.[J].Theriogenology, 2017, 103:143-148.
[5]	WANG F G, CHEN L, CHEN S X, et al.Association of RBP-4 gene polymorphisms with follicular cysts in large white sows[J].Reprod Domest Anim, 2019, 54(7):972-978.
[6]	HE F P, LIU Y H, LI T, et al.MicroRNA-146 attenuates lipopolysaccharide induced ovarian dysfunction by inhibiting the TLR4/NF-κB signaling pathway[J].Bioengineered, 2022, 13(5):11611-11623.
[7]	XIE F F, ZHANG J H, ZHAI M X, et al.Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway[J].Reproduction, 2021, 162(1):73-82.
[8]	ZHANG W F, HENG J H, KIM S W, et al.Dietary enzymatically-treated Artemisia annua L. supplementation could alleviate oxidative injury and improve reproductive performance of sows reared under high ambient temperature[J].J Therm Biol, 2020, 94:102751.
[9]	杨薇.猪舍温度对后备母猪培育的影响研究[D].重庆:西南大学, 2020.YANG W.Study on the influence of pig house temperature on the gilts breeding[D].Chongqing:Southwest University, 2020.(in Chinese)
[10]	袁雄坤, 姜丽丽, 陶诗煜, 等.母猪热应激敏感指标体系的研究进展[J].中国农业科学, 2020, 53(22):4691-4699.YUAN X K, JIANG L L, TAO S Y, et al.Research progresses on sensitive index system of heat stress in sows[J].Scientia Agricultura Sinica, 2020, 53(22):4691-4699.(in Chinese)
[11]	孙亚楠, 黄强, 岳隆耀, 等.影响我国母猪繁殖性能的主要因素分析[J].猪业科学, 2019, 36(12):104-107.SUN Y N, HUANG Q, YUE L Y, et al.Analysis of main factors affecting reproductive performance of Chinese sows[J].Swine Industry Science, 2019, 36(12):104-107.(in Chinese)
[12]	BERTOLDO M J, HOLYOAKE P K, EVANS G, et al.Seasonal variation in the ovarian function of sows[J].Reprod Fertil Dev, 2012, 24(6):822-834.
[13]	杨润泉, 方热军, 杨飞云, 等.环境温湿度和猪舍空气质量对妊娠母猪生产性能的影响[J].家畜生态学报, 2016, 37(12):40-43, 59.YANG R Q, FANG R J, YANG F Y, et al.Effect of environmental temperature, humidity, and air quality on performance of pregnant sows[J].Journal of Domestic Animal Ecology, 2016, 37(12):40-43, 59.(in Chinese)
[14]	JOHNSTON L J, LI Y Z.Performance and well-being of sows housed in pens retrofitted from gestation stalls[J].J Anim Sci, 2013, 91(12):5937-5945.
[15]	CHOE J, KIM S, CHO J H, et al.Effects of different gestation housing types on reproductive performance of sows[J].Anim Sci J, 2018, 89(4):722-726.
[16]	KOKETSU Y, IIDA R.Sow housing associated with reproductive performance in breeding herds[J].Mol Reprod Dev, 2017, 84(9):979-986.
[17]	GAO D Y, CAO X X, REN H H, et al.Immunotoxicity and uterine transcriptome analysis of the effect of zearalenone (ZEA) in sows during the embryo attachment period[J].Toxicol Lett, 2022, 357:33-42.
[18]	ZHOU J C, ZHAO L H, HUANG S M, et al.Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows[J].J Anim Sci Biotechnol, 2022, 13(1):36.
[19]	WARET-SZKUTA A, LARRAILLET L, OSWALD I P, et al.Unusual acute neonatal mortality and sow agalactia linked with ergot alkaloid contamination of feed[J].Porcine Health Manag, 2019, 5:24.
[20]	SHIN K T, GUO J, NIU Y J, et al.The toxic effect of aflatoxin B1 on early porcine embryonic development[J].Theriogenology, 2018, 118:157-163.
[21]	徐盛玉, 王定越, 吴德.镰刀菌毒素对母猪繁殖性能的影响及其作用途径[J].动物营养学报, 2010, 22(1):24-30.XU S Y, WANG D Y, WU D.Effects and action pathway of fusarium toxins on reproduction performance of sows[J].Chinese Journal of Animal Nutrition, 2010, 22(1):24-30.(in Chinese)
[22]	LAN M, ZHANG Y, WAN X, et al.Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes[J].Environ Pollut, 2020, 256:113374.
[23]	YANG X, LIU P L, CUI Y L, et al.Review of the reproductive toxicity of T-2 toxin[J].J Agric Food Chem, 2020, 68(3):727-734.
[24]	FANG L H, JIN Y H, JEONG J H, et al.Effects of dietary energy and protein levels on reproductive performance in gestating sows and growth of their progeny[J].J Anim Sci Technol, 2019, 61(3):154-162.
[25]	吴德, 林燕, 王亚.母猪能量和蛋白质营养研究进展[J].动物营养学报, 2022, 34(10):6167-6177.WU D, LIN Y, WANG Y.Research progress on energy and protein nutrition of sows[J].Chinese Journal of Animal Nutrition, 2022, 34(10):6167-6177.(in Chinese)
[26]	王洁, 张龙林, 丁亚南, 等.妊娠期日粮能量水平对母猪繁殖性能影响的研究进展[J].中国畜牧杂志, 2022, 58(4):47-53.WANG J, ZHANG L L, DING Y N, et al.Advances in effects of dietary energy on reproductive performance of pregnant sow[J].Chinese Journal of Animal Science, 2022, 58(4):47-53.(in Chinese)
[27]	TIAN M, CHEN J M, LIU J X, et al.Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance[J].Anim Nutr, 2020, 6(4):397-403.
[28]	LI Y, YANG M, ZHANG L J, et al.Dietary fiber supplementation in gestating sow diet improved fetal growth and placental development and function through serotonin signaling pathway[J].Front Vet Sci, 2022, 9:831703.
[29]	MEANS R T.Iron deficiency and iron deficiency anemia:implications and impact in pregnancy, fetal development, and early childhood parameters[J].Nutrients, 2020, 12(2):447.
[30]	张荣飞, 朴香淑.母猪赖氨酸需要研究进展[J].中国畜牧杂志, 2011, 47(6):65-68, 75.ZHANG R F, PU X S.Research progress on sow lysine is needed[J].Chinese Journal of Animal Science, 2011, 47(6):65-68, 75.(in Chinese)
[31]	PINELLI-SAAVEDRA A.Vitamin E in immunity and reproductive performance in pigs[J].Reprod Nutr Dev, 2003, 43(5):397-408.
[32]	吴小玲, 石建凯, 张攀, 等.硒对母猪繁殖性能的影响及其作用机制[J].动物营养学报, 2018, 30(2):444-450.WU X L, SHI J K, ZHANG P, et al.Effects of selenium on reproductive performance of sows and its mechanism[J].Chinese Journal of Animal Nutrition, 2018, 30(2):444-450.(in Chinese)
[33]	GARNER T B, HESTER J M, CAROTHERS A, et al.Role of zinc in female reproduction[J].Biol Reprod, 2021, 104(5):976-994.
[34]	ZANG J J, CHEN J S, TIAN J, et al.Effects of magnesium on the performance of sows and their piglets[J].J Anim Sci Biotechnol, 2014, 5(1):39.
[35]	徐丽华, 苏菲, 余斌, 等.2017-2020年浙江省猪主要病毒性传染病的流行病学调查与分析[J].中国兽医学报, 2022, 42(2):223-229.XU L H, SU F, YU B, et al.Epidemiological investigation and analysis of main viral infectious diseases in pigs in Zhejiang province from 2017 to 2020[J].Chinese Journal of Veterinary Science, 2022, 42(2):223-229.(in Chinese)
[36]	ZHOU H, PAN Y, LIU M D, et al.Prevalence of porcine pseudorabies virus and its coinfection rate in Heilongjiang Province in China from 2013 to 2018[J].Viral Immunol, 2020, 33(8):550-554.
[37]	TANG Q W, GE L R, TAN S G, et al.Epidemiological survey of four reproductive disorder associated viruses of sows in Hunan Province during 2019-2021[J].Vet Sci, 2022, 9(8):425.
[38]	李洪宇, 陈华丽, 赵宝凯.母猪子宫内膜炎治疗控制方案[J].黑龙江畜牧兽医, 2017(4):134-136.LI H Y, CHEN H L, ZHAO B K.Treatment and control protocol for endometritis in sows[J].Heilongjiang Animal Science and Veterinary Medicine, 2017(4):134-136.(in Chinese)
[39]	ZHANG L, WANG L K, DAI Y M, et al.Effect of sow intestinal flora on the formation of endometritis[J].Front Vet Sci, 2021, 8:663956.
[40]	KITAYA K, TAKEUCHI T, MIZUTA S, et al.Endometritis:new time, new concepts[J].Fertil Steril, 2018, 110(3):344-350.
[41]	秦雪, 沙懿文, 杨梦豪, 等.非编码RNA调控哺乳动物子宫内膜容受性和蜕膜化的研究进展[J].畜牧兽医学报, 2023, 54(4):1347-1358.QIN X, SHA Y W, YANG M H, et al.Advances in regulation of non-coding RNA on mammalian endometrial receptivity and decidualization[J].Acta Veterinaria et Zootechnica Sinica, 2023, 54(4):1347-1358.(in Chinese)
[42]	SINGH N, SETHI A.Endometritis-Diagnosis, Treatment and its impact on fertility-A Scoping Review[J].JBRA Assist Reprod, 2022, 26(3):538-546.
[43]	PIRTEA P, CICINELLI E, DE NOLA R, et al.Endometrial causes of recurrent pregnancy losses:Endometriosis, adenomyosis, and chronic endometritis[J].Fertil Steril, 2021, 115(3):546-560.
[44]	BRZOZOWSKA M, ROMANIEWICZ M, CAŁKA J, et al.Effects of substance P and neurokinin A on the contractile activity of inflamed porcine uterus[J].Int J Mol Sci, 2022, 23(21):13184.
[45]	OLIVIERO C, HEINONEN M, VALROS A, et al.Environmental and sow-related factors affecting the duration of farrowing[J]. Anim Reprod Sci, 2010, 119(1-2):85-91.
[46]	YU X R, FU C S, CUI Z C, et al.Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows[J].J Anim Sci, 2021, 99(10):skab257.
[47]	胡玥.雌激素调节猪炎性子宫内膜细胞的分子机制[D].重庆:西南大学, 2017.HU Y.Molecular mechanisms of estrogen regulating inflammatory endometrial cells in pigs[D].Chongqing:Southwest University, 2017.(in Chinese)
[48]	李洪宇, 陈华丽, 赵宝凯.母猪子宫内膜炎治疗控制方案[C]//第六届全球猪业论坛暨第十六届(2019)中国猪业发展大会会刊.武汉:中国畜牧业协会, 2019:221-225.LI H Y, CHEN H L, ZHAO B K.Treatment and control protocol for endometritis in sows[C]//Proceedings of the 6th Global Pig Industry Forum and the 16th (2019) China Pig Industry Development Conference.Wuhan:China Animal Agriculture Association, 2019:221-225.(in Chinese)
[49]	CANISSO I F, SEGABINAZZI L G T M, FEDORKA C E.Persistent breeding-induced endometritis in mares-A multifaceted challenge:from clinical aspects to immunopathogenesis and pathobiology[J].Int J Mol Sci, 2020, 21(4):1432.
[50]	SCOGGIN C F.Endometritis:Nontraditional therapies[J].Vet Clin North Am Equine Pract, 2016, 32(3):499-511.
[51]	WANG X Z, SONG X J, LIU C, et al.Active components and molecular mechanism of Syringa oblata Lindl. in the treatment of endometritis based on pharmacology network prediction[J].Front Vet Sc, 2022, 9:885952.
[52]	袁红, 练斯南, 张衡, 等.新型猪伪狂犬病流行情况及净化措施[J].中国动物检疫, 2016, 33(3):58-62.YUAN H, LIAN S N, ZHANG H, et al.The epidemic situation and purification measures of the new swine pseudorabies[J]. China Animal Health Inspection, 2016, 33(3):58-62.(in Chinese)
[53]	孙颖, 王雪莹, 梁婉, 等.2018年伪狂犬病病毒的流行特征及其遗传变异分析[J].畜牧兽医学报, 2020, 51(3):584-593.SUN Y, WANG X Y, LIANG W, et al.Epidemiological and evolutionary characteristics of pseudorabies virus in China in 2018[J].Acta Veterinaria et Zootechnica Sinica, 2020, 51(3):584-593.(in Chinese)
[54]	VERPOEST S, CAY B, FAVOREEL H, et al.Age-dependent differences in pseudorabies virus neuropathogenesis and associated cytokine expression[J].J Virol, 2017, 91(2):e02058-16.
[55]	许力士.伪狂犬病毒GXLB-2015、GXGG-2016株gI/gE双基因缺失并表达EGFP株的构建及其生物学特性分析[D].南宁:广西大学, 2019.XU L S.Construction of poseudorabies virus GXLB-2015, GXGG-2016 gI/gE gene deletin with EGFP expressing strain and its biological characteristics[D].Nanning:Guangxi University, 2019.(in Chinese)
[56]	HUAN C C, ZHOU Z Y, YAO J T, et al.The antiviral effect of panax notoginseng polysaccharides by inhibiting PRV adsorption and replication in vitro[J].Molecules, 2022, 27(4):1254.
[57]	XING Y X, WANG L M, XU G L, et al.Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy[J].Res Vet Sci, 2021, 140:18-25.
[58]	HU R M, WANG L Y, LIU Q Y, et al.Whole-genome sequence analysis of pseudorabies virus clinical isolates from pigs in China between 2012 and 2017 in China[J].Viruses, 2021, 13(7):1322.
[59]	FREULING C M, MVLLER T F, METTENLEITER T C.Vaccines against pseudorabies virus (PrV)[J].Vet Microbiol, 2017, 206:3-9.
[60]	张秀娟.猪细小病毒及其非结构蛋白NS1和NS2诱导猪胎盘滋养层细胞自噬作用与机制研究[D].杨凌:西北农林科技大学, 2020.ZHANG X J.The effects and mechanism of porcine placental trophoblast cell autophagy induced by porcine parvovirus and its non-structural proteins NS1 and NS2[D].Yangling:Northwest A&F University, 2020.(in Chinese)
[61]	邵婷.猪细小病毒VP2劫持宿主蛋白MCM3促进自身复制机制研究[D].杨凌:西北农林科技大学, 2021.SHAO T.The mechanism of porcine parvovirus VP2 promote own replication by hijacking host protein MCM3[D]. Yangling:Northwest A&F University, 2021.
[62]	CHEN S B, CHEN N N, MIAO B C, et al.Coatomer protein COPε, a novel NS1-interacting protein, promotes the replication of porcine parvovirus via attenuation of the production of type I interferon[J].Vet Microbiol, 2021, 261:109188.
[63]	DU Q, ZHANG X Z, XU N, et al.Chaperonin CCT5 binding with porcine parvovirus NS1 promotes the interaction of NS1 and COPε to facilitate viral replication[J].Vet Microbiol, 2022, 274:109574.
[64]	ZHANG J L, FAN J H, LI Y, et al.Porcine parvovirus infection causes pig placenta tissue damage involving nonstructural protein 1 (NS1)-induced intrinsic ROS/mitochondria-mediated apoptosis[J].Viruses, 2019, 11(4):389.
[65]	张洪玲.猪细小病毒诱导猪胎盘滋养层细胞凋亡信号转导通路研究[D].杨凌:西北农林科技大学, 2016.ZHANG H L.Signal transduction pathways of apoptosis induced by PPV infection in porcine placenta trophoblast cells[D]. Yangling:Northwest A&F University, 2016.(in Chinese)
[66]	张樑.猪细小病毒诱导猪黄体细胞凋亡及抑制孕酮产生机制研究[D].杨凌:西北农林科技大学, 2018.ZHANG L.Mechanisms on porcine luteal cells apoptosis and inhibition of progestrone production induced by porcine parvovirus[D].Yangling:Northwest A&F University, 2018.(in Chinese)
[67]	ZHANG L, WANG Z Y, ZHANG J, et al.Porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis[J].Biol Reprod, 2018, 98(4):558-569.
[68]	MA X, GUO Z H, ZHANG Z Q, et al.Ferulic acid isolated from propolis inhibits porcine parvovirus replication potentially through Bid-mediate apoptosis[J].Int Immunopharmacol, 2020, 83:106379.
[69]	RAHE M C, MURTAUGH M P.Mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus[J]. Viruses, 2017, 9(6):148.
[70]	HICKMANN F M W, BRACCINI NETO J, KRAMER L M, et al.Host genetics of response to porcine reproductive and respiratory syndrome in sows:reproductive performance[J].Front Genet, 2021, 12:707870.
[71]	LUNNEY J K, FANG Y, LADINIG A, et al.Porcine reproductive and respiratory syndrome virus (PRRSV):pathogenesis and interaction with the immune system[J].Annu Rev Anim Biosci, 2016, 4:129-154.
[72]	NOVAKOVIC P, DETMER S E, SULEMAN M, et al.Histologic changes associated with placental separation in gilts infected with porcine reproductive and respiratory syndrome virus[J].Vet Pathol, 2018, 55(4):521-530.
[73]	BARRERA-ZARATE J A, DETMER S E, PASTERNAK J A, et al.Effect of porcine reproductive and respiratory syndrome virus 2 on angiogenesis and cell proliferation at the maternal-fetal interface[J].Vet Pathol, 2022, 59(6):940-949.
[74]	GUIDONI P B, PASTERNAK J A, HAMONIC G, et al.Decreased tight junction protein intensity in the placenta of porcine reproductive and respiratory syndrome virus-2 infected fetuses[J].Placenta, 2021, 112:153-161.
[75]	杨汉春, 周磊.猪繁殖与呼吸综合征病毒的遗传变异与演化[J].生命科学, 2016, 28(3):325-336.YANG H C, ZHOU L.Genetic variation and evolution of porcine reproductive and respiratory syndrome virus[J].Chinese Bulletin of Life Sciences, 2016, 28(3):325-336.(in Chinese)
[76]	JIANG Y F, XIA T Q, ZHOU Y J, et al.Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain[J].Vet Microbiol, 2015, 179(3-4):242-249.
[77]	RAHE M C, MURTAUGH M P.Mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus[J].Viruses, 2017, 9(6):148.
[78]	BAI W J, WANG Z J, SUN P, et al.The molecular characteristic analysis of PRRSV GSWW/2015 strain and its pathogenicity to pigs[J].BMC Vet Res, 2018, 14(1):240.
[79]	YAO Y, ZHANG X, LI S H, et al.miR-142-3p suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by directly targeting Rac1[J].Vet Microbiol, 2022, 269:109434.
[80]	LONG S W, ZHOU Y R, BAI D C, et al.Fatty acids regulate porcine reproductive and respiratory syndrome virus infection via the AMPK-ACC1 signaling pathway[J].Viruses, 2019, 11(12):1145.
[81]	LUO X G, CHEN X X, QIAO S L, et al.Porcine reproductive and respiratory syndrome virus increases SOCS3 production via activation of p38/AP-1 signaling pathway to promote viral replication[J].Vet Microbiol, 2021, 257:109075.
[82]	KE W T, ZHOU Y R, LAI Y N, et al.Porcine reproductive and respiratory syndrome virus nsp4 positively regulates cellular cholesterol to inhibit type I interferon production[J].Redox Biol, 2022, 49:102207.
[83]	ZHU M, LI X Y, SUN R Q, et al.The C/EBPβ-dependent induction of TFDP2 facilitates porcine reproductive and respiratory syndrome virus proliferation[J].Virol Sin, 2021, 36(6):1341-1351.
[84]	SONG Y N, GUO Y Y, LI X Y, et al.RBM39 alters phosphorylation of c-Jun and binds to viral RNA to promote PRRSV proliferation[J].Front Immunol, 2021, 12:664417.
[85]	PENG J, YUAN Y M, DU Y J, et al.Potentiation of Taishan Pinus massoniana pollen polysaccharide on the immune response and protection elicited by a highly pathogenic porcine reproductive and respiratory syndrome virus glycoprotein 5 subunit in pigs[J].Mol Cell Probes, 2016, 30(2):83-92.
[86]	刘杰, 李柏珍, 伍树松, 等.枸杞多糖的生理功能及其在动物生产中的应用[J].动物营养学报, 2023, 35(4):2129-2142.LIU J, LI B Z, WU S S, et al.Physiological functions of Lycium barbarum polysaccharide and its application in animal production[J].Chinese Journal of Animal Nutrition, 2023, 35(4):2129-2142.(in Chinese)
[87]	WANG X, DONG W J, ZHANG X X, et al.Antiviral mechanism of tea polyphenols against porcine reproductive and respiratory syndrome virus[J].Pathogens, 2021, 10(2):202.
[88]	GUO C H, ZHU Z B, YU P, et al.Inhibitory effect of iota-carrageenan on porcine reproductive and respiratory syndrome virus in vitro[J].Antivir Ther, 2019, 24(4):261-270.
[89]	CHEN Y, LI H, WU L, et al.Ursolic acid derivatives are potent inhibitors against porcine reproductive and respiratory syndrome virus[J].RSC Adv, 2020, 10(38):22783-22796.
[90]	李倬伟, 王方, 王君君, 等.双香豆素对猪繁殖与呼吸综合征病毒的体外抑制作用[J].畜牧兽医学报, 2023, 54(3):1160-1168.LI Z W, WANG F, WANG J J, et al.Inhibitory effect of dicumarol on highly pathogenic porcine reproductive and respiratory syndrome virus in vitro[J].Acta Veterinaria et Zootechnica Sinica, 2023, 54(3):1160-1168.(in Chinese)
[91]	XU Z C, HUANG M Y, XIA Y B, et al.Emodin from Aloe inhibits Porcine reproductive and Respiratory syndrome virus via toll-like receptor 3 activation[J].Viruses, 2021, 13(7):1243.
[92]	吕其壮.猪圆环病毒2型ORF5蛋白功能分析和ORF4蛋白拮抗细胞凋亡机制研究[D].杨凌:西北农林科技大学, 2016.LV Q Z.Functional analysis of putative ORF5 protein of porcine circovirus type 2 and antiapoptotic mechanism of viral ORF4 protein[D].Yangling:Northwest A&F University, 2016.(in Chinese)
[93]	PENSAERT M B, SANCHEZ R E Jr, LADEKJÆR-MIKKELSEN A S, et al.Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection[J].Vet Microbiol, 2004, 98(2):175-183.
[94]	MAK C K, YANG C, JENG C R, et al.Reproductive failure associated with coinfection of porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus[J].Can Vet J, 2018, 59(5):525-530.
[95]	MENG X J.Porcine circovirus type 2 (PCV2):pathogenesis and interaction with the immune system[J].Annu Rev Anim Biosci, 2013, 1:43-64.
[96]	孙庆帅, 陈燕虹, 姚伦, 等.猪圆环病毒2型和3型混合感染引起的母猪繁殖障碍诊治[J].中国畜牧兽医, 2022, 49(10):3982-3993.SUN Q S, CHEN Y H, YAO L, et al.Diagnosis and treatment of reproductive disorders in sows caused by co-infection of PCV2 and PCV3[J].China Animal Husbandry & Veterinary Medicine, 2022, 49(10):3982-3993.(in Chinese)
[97]	李川.猪圆环病毒2型对猪黄体细胞的损伤及其机制研究[D].长沙:湖南农业大学, 2021.LI C.Damage of porcine circovirus type 2 to porcine luteal cells and the mechanism[D].Changsha:Hunan Agricultural University, 2021.(in Chinese)
[98]	CAO M X, WANG X R, HU W Y, et al.Regulatory effect of Panax notoginseng saponins on the oxidative stress and histone acetylation induced by porcine circovirus type 2[J].J Vet Med Sci, 2022, 84(4):600-609.
[99]	WU L J, CHEN J, ZHOU D N, et al.Anti-inflammatory activity of arctigenin against PCV2 infection in a mouse model[J].Vet Med Sci, 2022, 8(2):700-709.
[100]	FRANZO G, SEGALÉS J.Porcine circovirus 2 genotypes, immunity and vaccines:multiple genotypes but one single serotype[J]. Pathogens, 2020, 9(12):1049.
[101]	WANG H J, GU J Y, XING G, et al.Genetic diversity of porcine circovirus type 2 in China between 1999-2017[J].Transbound Emerg Dis, 2019, 66(1):599-605.

Research Progress on Main Causes and Mechanism of Sow Reproductive Disorder Syndrome

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