幼龄反刍动物瘤胃上皮细胞β-羟基丁酸代谢与调控机制

doi:10.11843/j.issn.0366-6964.2020.04.002

Abstract

Abstract: Beta-hydroxybutyric acid (BHBA) is one of the main components of ketones. BHBA is a metabolite of butyrate, which is produced by rumen microbial fermentation, in rumen epithelial cells. BHBA plays an important regulatory role in rumen epithelial cells proliferation and metabolism of ruminants. In recent years, most studies on BHBA have focused on liver ketogenesis, dairy cow ketosis and its effect on lactation. Little information is available in the literature regarding to the relationship and inherent mechanisms between BHBA and rumen epithelial cell growth in young ruminants. This review focuses on the formation and transport of BHBA in rumen epithelial cells, as well as the molecular mechanism of BHBA as a signal molecule regulating the metabolism and proliferation of rumen epithelial cells. This is of great significance to enrich the theory on regulation and development of rumen and the nutritional strategy for the rearing of young ruminants.

Key words: beta-hydroxybutyric acid, young ruminants, rumen epithelial cell, ketogenesis, cell proliferation

CLC Number:

S811.6

ZHUANG Yimin, DIAO Qiyu, ZHANG Naifeng. Metabolism and Regulation Mechanism of Beta-hydroxybutyric Acid in Ruminal Epithelium Cells of Young Ruminants[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(4): 660-669.

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Metabolism and Regulation Mechanism of Beta-hydroxybutyric Acid in Ruminal Epithelium Cells of Young Ruminants

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