全基因组选择信号揭示绵羊毛囊发育及脱毛性状相关的候选基因

doi:10.11843/j.issn.0366-6964.2022.02.006

Abstract

Abstract: In order to discover candidate genes related to hair follicle development and depilation traits, genome-wide selection signals were used to study the population structure and genetic differentiation of sheep with different wool types. In current study, the population of 290 sheep from 21 breeds with three types of wool was selected as research object, using Illumina Ovine SNP 50K microarrays genotyping data, based on Fst and θπ Ratio methods, the selection signal detection of hair sheep, fine wool sheep and medium wool sheep were detected. Apply the top 5% of Fst and θπ Ratio as the threshold to detect and annotate the strongly selected SNPs. The results showed that genes related to hair follicle development and hair loss traits such as SOX18, ALX4, FGF1 and LRP4 were strongly selected. In this study, two methods of Fst and θπ Ratio were adopted to detect important genes related to hair follicle development cycle, hair formation, and some cells of hair follicles and sebaceous glands. This will provide a meaningful reference for further research on the mechanism of important economic traits in sheep.

Key words: sheep, SNP chip, select signal, Fst, θπ Ratio

CLC Number:

S826.2

LEI Zhihui, ZHANG Liping, ZHAO Hongchang, ZHU Shaohua, LU Zengkui, GUO Tingting, SUN Weibo, HE Xue, YUE Yaojing. Genome-wide Selection Signals Reveal Candidate Genes Associated with the Sheep of Hair Follicle Development and Depilation Traits[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2): 381-390.

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Genome-wide Selection Signals Reveal Candidate Genes Associated with the Sheep of Hair Follicle Development and Depilation Traits

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