低温等离子体调控细胞增殖和凋亡的研究进展及其在畜牧业的应用

doi:10.11843/j.issn.0366-6964.2022.01.001

Abstract

Abstract: Non-thermal plasma (NTP) is the slightly ionized plasma. The temperature of its ions and neutral particles is far lower than that of electrons, making the whole discharge system in a low temperature state. At present, NTP is widely used in the sterilization, vaccine production, oral treatment, wound healing, cancer treatment and other biomedical fields. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by NTP have dose-dependent regulatrory effects on the cell proliferation and apoptosis. NTP treatments at a low intensity and short time can generate low levels of ROS and RNS, which will induce the cell proliferation and angiogenesis and thus to accelerate the wound healing. NTP treatments at a high intensity and long time can inhibit the cell proliferation and even induce the cell apoptosis. However, the mechanism of NTP regulating the cell proliferation and apoptosis and its potential application in the animal husbandry are still unclear. Therefore, this paper reviews the effects and possible mechanisms of NTP on endothelial cells, keratinocytes, fibroblasts, stem cells and malignant tumor cells, so as to provide a theoretical basis for the application of NTP in the wound healing and cancer treatment. This paper also summarizes the potential applications of NTP in the breeding environment and health, the growth and reproductive performance of livestock and poultry, as well as the animal food processing and preservation, so as to lay a foundation for promoting the animal husbandry production and ensuring the animal food safety in China.

Key words: non-thermal plasma, cell proliferation, cell apoptosis, wound healing, cancer treatment, animal husbandry application

CLC Number:

S852.2

LI Yaqi, WANG Xianzhong, ZHANG Jiaojiao. Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 1-10.

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Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry

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