低温等离子体调控细胞增殖和凋亡的研究进展及其在畜牧业的应用

doi:10.11843/j.issn.0366-6964.2022.01.001

Abstract

Abstract: Non-thermal plasma (NTP) is the slightly ionized plasma. The temperature of its ions and neutral particles is far lower than that of electrons, making the whole discharge system in a low temperature state. At present, NTP is widely used in the sterilization, vaccine production, oral treatment, wound healing, cancer treatment and other biomedical fields. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by NTP have dose-dependent regulatrory effects on the cell proliferation and apoptosis. NTP treatments at a low intensity and short time can generate low levels of ROS and RNS, which will induce the cell proliferation and angiogenesis and thus to accelerate the wound healing. NTP treatments at a high intensity and long time can inhibit the cell proliferation and even induce the cell apoptosis. However, the mechanism of NTP regulating the cell proliferation and apoptosis and its potential application in the animal husbandry are still unclear. Therefore, this paper reviews the effects and possible mechanisms of NTP on endothelial cells, keratinocytes, fibroblasts, stem cells and malignant tumor cells, so as to provide a theoretical basis for the application of NTP in the wound healing and cancer treatment. This paper also summarizes the potential applications of NTP in the breeding environment and health, the growth and reproductive performance of livestock and poultry, as well as the animal food processing and preservation, so as to lay a foundation for promoting the animal husbandry production and ensuring the animal food safety in China.

Key words: non-thermal plasma, cell proliferation, cell apoptosis, wound healing, cancer treatment, animal husbandry application

CLC Number:

S852.2

LI Yaqi, WANG Xianzhong, ZHANG Jiaojiao. Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 1-10.

References 73

[1]	CONRADS H,SCHMIDT M.Plasma generation and plasma sources[J].Plasma Sources Sci Technol,2000,9(4):441.
[2]	KÜÇÜK D,SAVRAN L,ERCAN U K,et al.Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis:a randomized controlled clinical trial[J].Clin Oral Invest,2020,24(9):3133-3145.
[3]	CÁMARA-TORRES M,SINHA R,SCOPECE P,et al.Tuning cell behavior on 3D scaffolds fabricated by atmospheric plasma-assisted additive manufacturing[J].ACS Appl Mater Interfaces,2021,13(3):3631-3644.
[4]	GAN L,JIANG J,DUAN J W,et al.Cold atmospheric plasma applications in dermatology:A systematic review[J].J Biophotonics, 2021,14(3):e202000415.
[5]	PLATTFAUT I,BESSER M,SEVERING A L,et al.Plasma medicine and wound management:Evaluation of the antibacterial efficacy of a medically certified cold atmospheric argon plasma jet[J].Int J Antimicrob Agents,2021,57(5):106319.
[6]	LIN L,WANG L L,LIU Y D,et al.Non-thermal plasma inhibits tumor growth and proliferation and enhances the sensitivity to radiation in vitro and in vivo[J].Oncol Rep,2018,40(6):3405-3415.
[7]	AKTER M,LIM J S,CHOI E H,et al.Non-thermal biocompatible plasma jet induction of apoptosis in brain cancer cells[J]. Cells, 2021,10(2):236.
[8]	ALIMOHAMMADI M,GOLPOUR M,SOHBATZADEH F,et al.Cold atmospheric plasma is a potent tool to improve chemotherapy in melanoma in vitro and in vivo[J].Biomolecules,2020,10(7):1011.
[9]	ZHU J J,THOMPSON C B.Metabolic regulation of cell growth and proliferation[J].Nat Rev Mol Cell Biol,2019,20(7): 436-450.
[10]	STEFANATOS R,SANZ A.The role of mitochondrial ROS in the aging brain[J].FEBS Lett,2018,592(5):743-758.
[11]	KALGHATGI S,FRIEDMAN G,FRIDMAN A,et al.Endothelial cell proliferation is enhanced by low dose non-thermal plasma through fibroblast growth factor-2 release[J].Ann Biomed Eng,2010,38(3):748-757.
[12]	WENDE K,STRAßENBURG S,HAERTEL B,et al.Atmospheric pressure plasma jet treatment evokes transient oxidative stress in HaCaT keratinocytes and influences cell physiology[J].Cell Biol Int,2014,38(4):412-425.
[13]	BALZER J,HEUER K,DEMIR E,et al.Non-thermal dielectric barrier discharge (DBD) effects on proliferation and differentiation of human fibroblasts are primary mediated by hydrogen peroxide[J].PLoS One,2015,10(12):e0144968.
[14]	YAHAYA A G,OKUYAMA T,KRISTOF J,et al.Direct and indirect bactericidal effects of cold atmospheric-pressure microplasma and plasma jet[J].Molecules,2021,26(9):2523.
[15]	KWON T,CHANDIMALI N,LEE D H,et al.Potential applications of non-thermal plasma in animal husbandry to improve infrastructure[J].In Vivo,2019,33(4):999-1010.
[16]	WANG G M,ZHU R H,YANG L C,et al.Non-thermal plasma for inactivated-vaccine preparation[J].Vaccine, 2016,34(8): 1126-1132.
[17]	JO K,LEE J,LEE S,et al.Curing of ground ham by remote infusion of atmospheric non-thermal plasma[J].Food Chem,2020, 309:125643.
[18]	ZHANG J J,JO J O,HUYNH D L,et al.Lethality of inappropriate plasma exposure on chicken embryonic development[J]. Oncotarget,2017,8(49):85642-85654.
[19]	ZHANG J J,WANG X Z,KWON T,et al.Innovative approach of non-thermal plasma application for improving the growth rate in chickens[J].Int J Mol Sci,2018,19(8):2301.
[20]	ZHANG J J,CHANDIMALI N,KIM N,et al.Demethylation and microRNA differential expression regulate plasma-induced improvement of chicken sperm quality[J].Sci Rep,2019,9(1):8865.
[21]	ZHANG J J,DO H L,CHANDIMALI N,et al.Non-thermal plasma treatment improves chicken sperm motility via the regulation of demethylation levels[J].Sci Rep,2018,8(1):7576.
[22]	ZHANG J J,HUYNH D L,CHANDIMALI N,et al.Growth and male reproduction improvement of non-thermal dielectric barrier discharge plasma treatment on chickens[J].J Phys D:Appl Phys,2018,51(20):205201.
[23]	ZHANG J J,WANG X Z,DO H L,et al.MicroRNA-7450 regulates non-thermal plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-activated protein kinase activation[J].Sci Rep,2018,8(1):8761.
[24]	OKAZAKI Y,TANAKA H,MATSUMOTO K I,et al.Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide[J]. Arch Biochem Biophys,2021,705:108901.
[25]	EMMERT S,VAN WELZEN A,MASUR K,et al.Cold atmospheric pressure plasma for the treatment of acute and chronic wounds[J].Hautarzt,2020,71(11):855-862.
[26]	ARNDT S,UNGER P,BERNEBURG M,et al.Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes,fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode[J].J Dermatol Sci, 2018,89(2):181-190.
[27]	AKTER M,YADAV D K,KI S H,et al.Inactivation of infectious bacteria using nonthermal biocompatible plasma cabinet sterilizer[J].Int J Mol Sci,2020,21(21):8321.
[28]	OKAZAKI Y,ISHIDZU Y,ITO F,et al.L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide[J].Arch Biochem Biophys,2021,700:108762.
[29]	SHI X M,XU G M,ZHANG G J,et al.Low-temperature plasma promotes fibroblast proliferation in wound healing by ROS-activated NF-κB signaling pathway[J].Curr Med Sci,2018,38(1):107-114.
[30]	TAN F,FANG Y,ZHU L W,et al.Controlling stem cell fate using cold atmospheric plasma[J].Stem Cell Res Ther,2020,11(1): 368.
[31]	NOSRATI H,ARAMIDEH KHOUY R,NOSRATI A,et al.Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis[J].J Nanobiotechnol,2021,19(1):1.
[32]	LABERGE A,ARIF S,MOULIN V J.Microvesicles:Intercellular messengers in cutaneous wound healing[J].J Cell Physiol,2018, 233(8): 5550-5563.
[33]	DUARTE S,PANARIELLO B H D.Comprehensive biomedical applications of low temperature plasmas[J].Arch Biochem Biophys,2020,693:108560.
[34]	BRANY D,DVORSKÝ D,HALAÁOVŠ E,et al.Cold atmospheric Plasma:a powerful tool for modern medicine[J].Int J Mol Sci,2020,21(8):2932.
[35]	ARJUNAN K P,FRIEDMAN G,FRIDMAN A,et al.Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species[J].J R Soc Interface,2012,9(66):147-157.
[36]	VELNAR T,GRADISNIK L.Tissue augmentation in wound healing:the role of endothelial and epithelial cells[J].Med Arch,2018,72(6):444-448.
[37]	BENINGTON L,RAJAN G,LOCHER C,et al.Fibroblast growth factor 2-a review of stabilisation approaches for clinical applications[J].Pharmaceutics,2020,12(6):508.
[38]	SIMONS M,GORDON E,CLAESSON-WELSH L.Mechanisms and regulation of endothelial VEGF receptor signalling[J]. Nat Rev Mol Cell Biol,2016,17(10):611-625.
[39]	PIIPPONEN M,LI D Q,LANDÉN N X.The immune functions of keratinocytes in skin wound healing[J].Int J Mol Sci, 2020, 21(22):8790.
[40]	PELAIA G,CUDA G,VATRELLA A,et al.Effects of hydrogen peroxide on MAPK activation,IL-8 production and cell viability in primary cultures of human bronchial epithelial cells[J].J Cell Biochem,2004,93(1):142-152.
[41]	GUO Y J,PAN W W,LIU S B,et al.ERK/MAPK signalling pathway and tumorigenesis[J].Exp Ther Med,2020,19(3): 1997-2007.
[42]	LOU B S,HSIEH J H,CHEN C M,et al.Helium/argon-generated cold atmospheric plasma facilitates cutaneous wound healing[J].Front Bioeng Biotechnol,2020,8:683.
[43]	CABEZAS S,HO S,ROS U,et al.Damage of eukaryotic cells by the pore-forming toxin sticholysin II:Consequences of the potassium efflux[J].Biochim Biophys Acta Biomembr,2017,1859(5):982-992.
[44]	HOTTA E,HARA H,KAMIYA T,et al.Non-thermal atmospheric pressure plasma-induced IL-8 expression is regulated via intracellular K+ loss and subsequent ERK activation in human keratinocyte HaCaT cells[J].Arch Biochem Biophys,2018,644:64-71.
[45]	URABE H,AKIMOTO R,KAMIYA S,et al.Effects of pulsed electrical stimulation on growth factor gene expression and proliferation in human dermal fibroblasts[J].Mol Cell Biochem,2021,476(1):361-368.
[46]	OECKINGHAUS A,GHOSH S.The NF-κB family of transcription factors and its regulation[J].Cold Spring Harb Perspect Biol,2009,1(4):a000034.
[47]	XU G M,SHI X M,CAI J F,et al.Dual effects of atmospheric pressure plasma jet on skin wound healing of mice[J].Wound Repair Regen,2015,23(6):878-884.
[48]	PARK J,LEE H,LEE H J,et al.Non-thermal atmospheric pressure plasma is an excellent tool to activate proliferation in various mesoderm-derived human adult stem cells[J].Free Radic Biol Med,2019,134:374-384.
[49]	MOZAFFARI A,GASHTI M P,MIRJALILI M,et al.Argon and argon-oxygen plasma surface modification of gelatin nanofibers for tissue engineering applications[J].Membranes (Basel),2021,11(1):31.
[50]	BIAZAR E,HEIDARI M,ASEFNEJAD A,et al.The relationship between cellular adhesion and surface roughness in polystyrene modified by microwave plasma radiation[J].Int J Nanomedicine,2011,6(3):631-639.
[51]	PRASERTSUNG I,KANOKPANONT S,MONGKOLNAVIN R,et al.Comparison of the behavior of fibroblast and bone marrow-derived mesenchymal stem cell on nitrogen plasma-treated gelatin films[J].Mater Sci Eng C Mater Biol Appl,2013,33(7): 4475-4479.
[52]	MARTÍNEZ-RUIZ A,CADENAS S,LAMAS S.Nitric oxide signaling:classical,less classical,and nonclassical mechanisms[J]. Free Radic Biol Med,2011,51(1):17-29.
[53]	PARK J,LEE H,LEE H J,et al.Non-thermal atmospheric pressure plasma efficiently promotes the proliferation of adipose tissue-derived stem cells by activating NO-response pathways[J].Sci Rep,2016,6(1):39298.
[54]	PARK J,SUH D,TANG T Y,et al.Non-thermal atmospheric pressure plasma induces epigenetic modifications that activate the expression of various cytokines and growth factors in human mesoderm-derived stem cells[J].Free Radic Biol Med,2020,148: 108-122.
[55]	CAO W,CHEN H D,YU Y W,et al.Changing profiles of cancer burden worldwide and in China:a secondary analysis of the global cancer statistics 2020[J].Chin Med J (Engl),2021,134(7):783-791.
[56]	KEIDAR M,WALK R,SHASHURIN A,et al.Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy[J].Br J Cancer,2011,105(9):1295-1301.
[57]	WANG L Y,YANG X Y,YANG C J,et al.The inhibition effect of cold atmospheric plasma-activated media in cutaneous squamous carcinoma cells[J].Future Oncol,2019,15(5):495-505.
[58]	WU H,LIN J,LIU P D,et al.Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs[J].Biomaterials,2016,101:1-9.
[59]	CHANG J W,KANG S U,SHIN Y S,et al.Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma:Involvement of DNA-damage-triggering sub-G1 arrest via the ATM/p53 pathway[J].Arch Biochem Biophys,2014,545:133-140.
[60]	ISHAQ M,KUMAR S,VARINLI H,et al.Atmospheric gas plasma-induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis[J].Mol Biol Cell,2014,25(9):1523-1531.
[61]	KNAUS U G.Oxidants in physiological processes[J].Handb Exp Pharmacol,2021,264:27-47.
[62]	ISHAQ M,EVANS M D M,OSTRIKOV K K.Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system[J].Biochim Biophys Acta,2014,1843(12):2827-2837.
[63]	MOSCA F,ZANIBONI L,ABDEL SAYED A,et al.Effect of dimethylacetamide and N-methylacetamide on the quality and fertility of frozen/thawed chicken semen[J].Poult Sci,2019,98(11):6071-6077.
[64]	MONTJEAN D,ZINI A,RAVEL C,et al.Sperm global DNA methylation level:association with semen parameters and genome integrity[J].Andrology,2015,3(2):235-240.
[65]	QIU L Q,ZHANG M,TANG J M,et al.Innovative technologies for producing and preserving intermediate moisture foods:A review[J].Food Res Int,2019,116:90-102.
[66]	PARTHASARATHY D K,BRYAN N S.Sodium nitrite:the "cure" for nitric oxide insufficiency[J].Meat Sci,2012, 92(3):274-279.
[67]	WANG J M,ZHUANG H,LAWRENCE K,et al.Disinfection of chicken fillets in packages with atmospheric cold plasma: effects of treatment voltage and time[J].J Appl Microbiol,2018,124(5):1212-1219.
[68]	DIRKS B P,DOBRYNIN D,FRIDMAN G,et al.Treatment of raw poultry with nonthermal dielectric barrier discharge plasma to reduce Campylobacter jejuni and Salmonella enterica[J].J Food Prot,2012,75(1):22-28.
[69]	JAYASENA D D,KIM H J,YONG H I,et al.Flexible thin-layer dielectric barrier discharge plasma treatment of pork butt and beef loin:effects on pathogen inactivation and meat-quality attributes[J].Food Microbiol,2015,46:51-57.
[70]	LEE E S,JEON Y J,MIN S C.Microbial inactivation and quality preservation of chicken breast salad using atmospheric dielectric barrier discharge cold plasma treatment[J].Foods,2021,10(6):1214.
[71]	GUROL C,EKINCI F Y,ASLAN N,et al.Low temperature plasma for decontamination of E. coli in milk[J].Int J Food Microbiol, 2012,157(1):1-5.
[72]	RAGNI L,BERARDINELLI A,VANNINI L,et al.Non-thermal atmospheric gas plasma device for surface decontamination of shell eggs[J].J Food Eng,2010,100(1):125-132.
[73]	ZIUZINA D,PATIL S,CULLEN P J,et al.Atmospheric cold plasma inactivation of Escherichia coli in liquid media inside a sealed package[J].J Appl Microbiol,2013,114(3):778-787.

Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 73

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHANG Wanfeng, ZHAO Tianzhi, LI Jiao, YOU Ziwei, YANG Yang, CAI Chunbo, GAO Pengfei, CAO Guoqing, GUO Xiaohong, LI Bugao. Study on NR2F2 Gene Regulating Proliferation and Apoptosis of Porcine PK15 Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3242-3251.
[2]	WANG Wanjie, CHEN Nanzhu, ZOU Huiying, ZHOU Xinyi, HAO Haisheng, PANG Yunwei, ZHU Huabin, ZHAO Xueming, YU Dawei, DU Weihua. Effects of Histone Methyltransferase ASH1L Overexpression on Proliferation and Apoptosis of Bovine Cumulus Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3358-3368.
[3]	JIAO Guangming, LÜ Yingguang, SANG Jinfang, KOU Zhipeng, LIU Tao, WANG Yue, LU Xiangyu, PIAO Chenxi, MA Yajun, ZHANG Jiantao, WANG Hongbin. Effect of Adipose Mesenchymal Stem Cells in Combination with Methylprednisolone on Allogeneic Skin Grafts in Minipigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3533-3545.
[4]	ZHANG Peng, WANG Mingxiu, JING Kemin, PENG Wei, TIAN Yuan, LI Yuqian, FU Changqi, SHU Shi, ZHONG Jincheng, CAI Xin. Abnormal Expression of FGFs/FGFRs and Their Mediated Signaling Pathway Genes Affect the Proliferative Activity of Undifferentiated Spermatogonia in Cattleyak [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2886-2897.
[5]	XU Tiantian, ZHANG Tongtong, WANG Meng, WANG Xin. Transcription Factor Foxq1 Affects the Proliferation of Hair Follicle Stem Cells in Cashmere Goats via WNT/β-catenin Signaling Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2653-2661.
[6]	DAN Yixin, YANG Lu, XIANG Hua, ZHANG Huanrong, REN Yupeng, YANG Falong, HE Honghong, ZHU Jiangjiang. Effects of BIRC5 on the Cycle and Apoptosis of Goat Testis Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1511-1524.
[7]	REN Xiaoli, FAN Yuying, HUANGFU Heping, LIU Yun, SHI Dongmei. Effect of GSK126 on Epithelial-mesenchymal Transition of Canine Mammary Tumor Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1721-1729.
[8]	YANG Guang, XU Jing, LI Xin, HU Debao, GUO Yiwen, DING Xiangbin, GUO Hong, ZHANG Linlin. Effect of Interfering lncbMD on Proliferation and Differentiation of Bovine Skeletal Muscle Satellite Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1015-1025.
[9]	SUN Jinkui, XU Houqiang, SHI Pengfei, RUAN Yong. Construction of MEF2A Gene Interference Vector and Effect of Its Transfection on Myoblasts in Guanling Cattle [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 584-595.
[10]	MA Tianwen, YU Yue, LÜ Liangyu, JIA Lina, RUAN Hongri, WANG Haoran, WANG Xinyu, ZHANG Yuxin, ZHANG Jiantao, GAO Li. Effects of Bilobalide on Autophagy, Proliferation and Apoptosis of IL-1β-induced ATDC5 Chondrocytes [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 837-846.
[11]	REN Xiaoli, FAN Yuying, HUANGFU Heping, WANG Jun, JIN Shuangxing, LIU Yun, SHI Dongmei. Mechanism of miR-502 Regulating Proliferation, Migration, Invasion and EMT of Canine Mammary Tumor Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4379-4388.
[12]	WEI Jiayuan, ZHU Qian, YANG Yaxing, SHEN Ming. Inhibition of Porcine Follicular Granulosa Cell Proliferation by Cobalt Chloride Induced DNA Oxidative Damage [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 2982-2992.
[13]	XU Songwei, XIANG Hua, ZHANG Huanrong, YANG Lu, WANG Xianjun, SALANG Wenzhu, ZHU Jiangjiang. Effects of Interfering SERBP1 on the Cell Proliferation, Cell Cycle and Apoptosis in Goat Turbinate Bone Primary Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2708-2720.
[14]	CHEN Lan, ZHANG Tao, DING Hao, XIE Kaizhou, ZHANG Genxi, WANG Jinyu. Effects of Kruppel-like Factor 15 Gene on Proliferation and Differentiation of Preadipocytes of Heying Black Chickens [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2118-2129.
[15]	ZHANG Zhenzhen, LI Jianzeng, JIANG Ruirui, MA Yanchao, CAI Chunxia, ZHANG Lujie, GUO Yujie, JI Jinqing, HAN Lu, TIAN Yadong, KANG Xiangtao, HAN Ruili. Isolation, Culture and Identification of Chicken Chondrocytes and the Effect of Overexpression of miR-15a on Chondrocytes [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1749-1758.