CAF-1在体细胞重编程中的作用机制

doi:10.11843/j.issn.0366-6964.2021.07.001

Abstract

Abstract: Chromatin assembly factor-1 (CAF-1) is a histone chaperone composed of 3 subunits(p150, p60, and p48).CAF-1 mainly interacts with proliferating cell nuclear antigen (PCNA) during DNA replication and is responsible for recruiting histones H3 and H4 depositing on newly synthesized DNA to facilitate nucleosome assembly. More and more studies have analyzed the structure and biological function of the CAF-1 complex,and found that CAF-1 plays an important role in the process of somatic cell reprogramming. Therefore, this paper focuses on the structure, biological function and the role of CAF-1 in somatic cell reprogramming.

Key words: CAF-1, somatic cell reprogramming, structure, function

CLC Number:

Q952.6

ZHANG Yingbing, YU Ruiluan, QIAO Peipei, YANG Ying, ZHANG Yong, SU Jianmin. The Mechanism of CAF-1 in Somatic Cell Reprogramming[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1769-1777.

References 62

[1]	STILLMAN B.Chromatin assembly during SV40 DNA replication in vitro[J].Cell,1986,45(4):555-565.
[2]	SMITH S,STILLMAN B.Purification and characterization of CAF-I,a human cell factor required for chromatin assembly during DNA replication in vitro[J].Cell,1989,58(1):15-25.
[3]	UWADA J,TANAKA N,YAMAGUCHI Y,et al.The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci[J].Biochem Biophys Res Commun,2010,391(1):407-413.
[4]	THIRU A,NIETLISPACH D,MOTT H R,et al.Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin[J].EMBO J,2004,23(3):489-499.
[5]	MATTIROLI F,GU Y J,YADAV T,et al.DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1(CAF-1) drives tetrasome assembly in the wake of DNA replication[J].eLife,2017,6:e22799.
[6]	ZHANG K,GAO Y,LI J J,et al.A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks[J].Nucleic Acids Res,2016,44(11):5083-5094.
[7]	TANG Y,POUSTOVOITOV M V,ZHAO K H,et al.Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly[J].Nat Struct Mol Biol,2006,13(10):921-929.
[8]	TYLER J K,COLLINS K A,PRASAD-SINHA J,et al.Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors[J].Mol Cell Biol,2001,21(19):6574-6584.
[9]	ENGLISH C M,ADKINS M W,CARSON J J,et al.Structural basis for the histone chaperone activity of Asf1[J].Cell, 2006,127(3):495-508.
[10]	TAGAMI H,RAY-GALLET D,ALMOUZNI G,et al.Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis[J].Cell,2004,116(1):51-61.
[11]	VERREAULT A,KAUFMAN P D,KOBAYASHI R,et al.Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4[J].Cell,1996,87(1):95-104.
[12]	TAUNTON J,HASSIG C A,SCHREIBER S L.A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p[J].Science,1996,272(5260):408-411.
[13]	SONG J J,GARLICK J D,KINGSTON R E.Structural basis of histone H4 recognition by p55[J].Genes Dev,2008, 22(10):1313-1318.
[14]	SAUER P V,GU Y J,LIU W H,et al.Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1[J].Nucleic Acids Res,2018,46(19):9907-9917.
[15]	VOLK A,CRISPINO J D.The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease[J].Biochim Biophys Acta Gene Regulat Mech,2015,1849(8):979-986.
[16]	LI Q,ZHOU H,WURTELE H,et al.Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly[J].Cell,2008,134(2):244-255.
[17]	HUANG T H,FOWLER F,CHEN C C,et al.The histone chaperones ASF1 and CAF-1 promote MMS22L-TONSL-mediated Rad51 Loading onto ssDNA during homologous recombination in human cells[J].Mol Cell,2018,69(5):879-892.e5.
[18]	TJEERTES J V,MILLER K M,JACKSON S P.Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells[J].EMBO J,2009,28(13):1878-1889.
[19]	VEMPATI R K,JAYANI R S,NOTANI D,et al.p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals[J].J Biol Chem,2010,285(37):28553-28564.
[20]	BURGESS R J,ZHOU H,HAN J H,et al.A role for Gcn5 in replication-coupled nucleosome assembly[J].Mol Cell,2010, 37(4):469-480.
[21]	ALLIS C D,CHICOINE L G,RICHMAN R,et al.Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena[J].Proc Natl Acad Sci U S A,1985,82(23):8048-8052.
[22]	SOBEL R E,COOK R G,ALLIS C D.Non-random acetylation of histone H4 by a cytoplasmic histone acetyltransferase as determined by novel methodology[J].J Biol Chem,1994,269(28):18576-18582.
[23]	SOBEL R E,COOK R G,PERRY C A,et al.Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4[J].Proc Natl Acad Sci U S A,1995,92(4):1237-1241.
[24]	PENG X D,FU H Y,YIN J J,et al.CHAF1B knockdown blocks migration in a hepatocellular carcinoma model[J].Oncol Rep,2018,40(1):405-413.
[25]	DUAN Y,LIU T Z,LI S W,et al.CHAF1B promotes proliferation and reduces apoptosis in 95-D lung cancer cells and predicts a poor prognosis in non-small cell lung cancer[J].Oncol Rep,2019,41(4):2518-2528.
[26]	YU Z S,LIU J Y,DENG W M,et al.Histone chaperone CAF-1:essential roles in multi-cellular organism development[J].Cell Mol Life Sci,2015,72(2):327-337.
[27]	XU M,JIA Y L,LIU Z K,et al.Chromatin assembly factor 1,subunit A (P150) facilitates cell proliferation in human hepatocellular carcinoma[J].Onco Targets Ther,2016,9:4023-4035.
[28]	VOLK A,LIANG K W,SURANENI P,et al.A CHAF1B-dependent molecular switch in hema-topoiesis and leukemia pathogenesis[J].Cancer cell,2018,34(5):707-723.e7.
[29]	DI M P,WANG M,MIAO J J,et al.CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma[J].Biomed Pharma-cother,2020,123:109748.
[30]	BARBIERI E,DE PRETER K,CAPASSO M,et al.Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma[J].Cancer Res,2014,74(3):765-774.
[31]	CHELOUFI S,ELLING U,HOPFGARTNER B,et al.The histone chaperone CAF-1 safeguards somatic cell identity[J].Nature, 2015,528(7581):218-224.
[32]	YOUNG T J,CUI Y,PFEFFER C,et al.CAF-1 and Rtt101p function within the replication-coupled chromatin assembly network to promote H4 K16ac,preventing ectopic silencing[J].PLoS Genet,2020,16(12):e1009226.
[33]	HUANG H,YU Z S,ZHANG S Q,et al.Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability[J].J Cell Sci,2010,123(Pt 16):2853-2861.
[34]	ROELENS B,CLÉMOT M,LEROUX-COYAU M,et al.Maintenance of heterochromatin by the large subunit of the CAF-1 replication-coupled histone chaperone requires its interaction with HP1a through a conserved motif[J].Genetics,2017,205(1):125-137.
[35]	YANG B X,EL FARRAN C A,GUO H C,et al.Systematic identification of factors for provirus silencing in embryonic stem cells[J].Cell,2015,163(1):230-245.
[36]	NG C, AICHINGER M, NGUYEN T, et al.The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells[J].Genes Dev,2019,33(11-12):669-683.
[37]	HATANAKA Y,INOUE K,OIKAWA M,et al.Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons[J].Proc Natl Acad Sci U S A,2015,112(47):14641-14646.
[38]	JIANG D H,BERGER F.DNA replication-coupled histone modification maintains Polycomb gene silencing in plants[J]. Science, 2017,357(6356):1146-1149.
[39]	CHENG L,ZHANG X,WANG Y,et al.Chromatin Assembly Factor 1(CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit[J].Nucleic Acids Res,2019,47(21):11114-11131.
[40]	CHELOUFI S,HOCHEDLINGER K.Emerging roles of the histone chaperone CAF-1 in cellular plasticity[J].Curr Opin Genet Dev,2017,46:83-94.
[41]	ZHANG L,YU M Y,XU H Y,et al.RNA sequencing revealed the abnormal transcriptional profile in cloned bovine embryos[J].Int J Biol Macromol,2020,150:492-500.
[42]	AN Q L,PENG W,CHENG Y Y,et al.Melatonin supplementation during in vitro maturation of oocyte enhances subsequent development of bovine cloned embryos[J].J Cell Physiol,2019,234(10):17370-17381.
[43]	ZHOU C,WANG Y Z,ZHANG J C,et al.H3K27 me3 is an epigenetic barrier while KDM6A overexpression improves nuclear reprogramming efficiency[J].FASEB J,2019,33(3):4638-4652.
[44]	梁素丽,李向臣,靳亚平,等.蛋白酶抑制剂MG-132对牛核移植重构胚重编程的影响[J].畜牧兽医学报, 2010,41(12):1536-1542.LIANG S L,LI X C,JIN Y P,et al.Effects of protease inhibitor MG-132 on nuclear remodeling of bovine nuclear transfer reconstructed embryos[J].Acta Veterinaria et Zootechnica Sinica,2010,41(12):1536-1542. (in Chinese)
[45]	MATOBA S,LIU Y T,LU F L,et al.Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation[J].Cell,2014,159(4):884-895.
[46]	ISHIUCHI T,ABE S,INOUE K,et al.Reprogramming of the histone H3.3 landscape in the early mouse embryo[J].Nat Struct Mol Biol,2021,28(1):38-49.
[47]	ISHIUCHI T,ENRIQUEZ-GASCA R,MIZUTANI E,et al.Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly[J].Nat Struct Mol Biol,2015,22(9):662-671.
[48]	CHUNG Y G,MATOBA S,LIU Y T,et al.Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells[J].Cell Stem Cell,2015,17(6):758-766.
[49]	SAMPAIO R V,SANGALLI J R,DE BEM T H C,et al.Catalytic inhibition of H3K9 me2 writers disturbs epigenetic marks during bovine nuclear reprogram-ming[J].Sci Rep,2020,10(1):11493.
[50]	PEASTON A E,EVSIKOV A V,GRABER J H,et al.Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos[J].Dev Cell,2004,7(4):597-606.
[51]	EVSIKOV A V,DE VRIES W N,PEASTON A E,et al.Systems biology of the 2-cell mouse embryo[J].Cytogenet Genome Res,2004,105(2-4):240-250.
[52]	PROBST A V,OKAMOTO I,CASANOVA M,et al.A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development[J].Dev Cell,2010,19(4):625-638.
[53]	GOMES A P,ILTER D,LOW V,et al.Dynamic incorporation of histone h3 variants into chromatin is essential for acquisition of aggressive traits and metastatic colonization[J].Cancer cell,2019,36(4):402-417.e13.
[54]	WANG Y L,LI Y H,LUAN D J,et al.Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos[J].Theriogenology,2020,154:43-52.
[55]	YAN H Y,XIANG X F,CHEN Q F,et al.HP1 cooperates with CAF-1 to compact heterochromatic transgene repeats in mammalian cells[J].Sci Rep,2018,8(1):14141.
[56]	FILIPESCU D,SZENKER E,ALMOUZNI G.Developmental roles of histone H3 variants and their chaperones[J].Trends Genet,2013,29(11):630-640.
[57]	HAKE S B,ALLIS C D.Histone H3 variants and their potential role in indexing mammalian genomes:the "H3 barcode hypothesis"[J].Proc Natl Acad Sci U S A,2006,103(17):6428-6435.
[58]	LIU X,WANG Y Z,GAO Y P,et al.H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming[J].Development,2018,145(4):dev158261.
[59]	AKIYAMA T,SUZUKI O,MATSUDA J,et al.Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos[J].PLoS Genet,2011,7(10):e1002279.
[60]	RAY-GALLET D,WOOLFE A,VASSIAS I,et al.Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity[J].Mol Cell,2011,44(6):928-941.
[61]	CHELOUFI S,ELLING U,HOPFGARTNER B,et al.The histone chaperone CAF-1 safeguards somatic cell identity[J].Nature,2015,528(7581):218-224.
[62]	SERRA-CARDONA A,ZHANG Z G.Replication-coupled nucleosome assembly in the passage of epigenetic information and cell identity[J].Trends Biochem Sci,2018,43(2):136-148.

The Mechanism of CAF-1 in Somatic Cell Reprogramming

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