饲喂PRL抑制剂对燕山绒山羊毛囊发育的影响

doi:10.11843/j.issn.0366-6964.2021.012.016

Abstract

Abstract: This experiment was conducted to study the effect of prolactin (PRL) inhibitor on hair follicle development of cashmere goats during anagen. Twenty healthy Yanshan cashmere goats with similar body weight ((23.01±4.82)kg) aged 3 months old were selected. Goats were randomly divided into two groups with 10 goats in each group, which were control group and experimental group, respectively. The goats in experimental group were fed PRL inhibitor (0.06 mg·kg^-1) for 90 days. At the end of the experiment, cashmere fiber, blood and skin samples were collected to analyze the effects of PRL inhibitor on the length and fineness of cashmere, blood indexes, hair follicle traits and the expression levels of PRL, MTNR1a and RORα mRNA in skin tissues. The results indicated that the length and diameter of fibers were not significantly influenced (P>0.05) by the PRL inhibitor. The PRL inhibitor significantly increased primary and secondary hair follicle numbers and the ratio of secondary number to primary number (S/P,P<0.05), and significantly increased the percentage of active primary and secondary hair follicles in anagen (P<0.05). The PRL inhibitor had no significant effect on the serum concentrations of PRL, melatonin (MT), insulin-like growth factor-1(IGF-1), cortisol (COR), growth hormone (GH), tetraiodothyronine (T₄) and triiodothyronine (T₃), but significantly decreased mRNA expressions of PRL and MTNR1a in skin (P<0.05), and had no significant effect on mRNA expression of RORα (P>0.05). Inhibition of PRL secretion during the anagen phase of goat hair follicle may promote hair follicle development by reducing the expression of PRL and MTNR1a genes in the skin.

Key words: cashmere goat, PRL, secondary hair follicle, blood indicator, MTNR1a

CLC Number:

S827.4

ZHANG Lechao, DUAN Chunhui, LIU Yueqin, ZHANG Yingjie. Effect of PRL Inhibitor on Hair Follicle Development of Yanshan Cashmere Goat[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3492-3500.

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Effect of PRL Inhibitor on Hair Follicle Development of Yanshan Cashmere Goat

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