动物疱疹病毒pUL7的生物学功能

doi:10.11843/j.issn.0366-6964.2025.12.010

摘要/Abstract

摘要：

UL7基因在疱疹病毒科成员中高度保守，其编码的pUL7蛋白在病毒感染的致病调控过程中发挥着关键的生物学作用。本文梳理了UL7基因编码蛋白的结构特征，并全面总结了pUL7在病毒复制、转录、蛋白表达、病毒粒子组装与释放等生命周期关键阶段的功能，同时探讨了其与其他病毒及宿主蛋白的相互作用机制，旨在为疱疹病毒UL7基因的深入研究提供参考。

关键词: 疱疹病毒, pUL7, 蛋白结构, 功能

Abstract:

The UL7 gene is highly conserved among members of the Herpesviridae family, and its encoded pUL7 protein plays a critical biological role in the pathogenic regulation of viral infection. This review systematically outlines the structural characteristics of the UL7-encoded protein and comprehensively summarizes the functions of pUL7 in key stages of the viral life cycle, including review systematically summarizes the structural characteristics of UL7-encoded proteins and the replication, transcription, protein expression, virion assembly, and release. Additionally, it explores the interaction mechanisms between pUL7 and other viral or host proteins, aiming to provide valuable insights for further research on the UL7 gene in herpesviruses.

Key words: herpes virus, UL7 protein, protein structure, function

中图分类号:

S852.659.1

兰星, 汪铭书, 程安春. 动物疱疹病毒pUL7的生物学功能[J]. 畜牧兽医学报, 2025, 56(12): 6046-6059.

LAN Xing, WANG Mingshu, CHENG Anchun. Biological Functions of the Animal Herpesvirus pUL7[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(12): 6046-6059.

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病毒 Virus	基因 Gene	氨基酸数量 Number of amino acids	蛋白分子量/ku Protein molecular weight	亚科 Subfamily	复制 Replication	基因类型 Gene type	参考文献 References
HSV-1	UL7	296	33	Alpha	有影响Influential	L	[45-46]
HSV-2	UL7	296	33	Alpha	有影响Influential	γ1	[47]
VZV	ORF53	331	40	Alpha	未报道Unreported	未报道Unreported	[48]
PRV	UL7	266	29	Alpha	有影响Influential	未报道Unreported	[49]
BHV-1	UL7	300	33	Alpha	有影响Influential	E	[50]
MDV	UL7	258	29.6	Alpha	未报道Unreported	未报道Unreported	[51]
DPV	UL7	321	36	Alpha	未报道Unreported	γ2	[52]
ILTV	UL7	358	40.9	Alpha	未报道Unreported	E	[53]
HCMV	UL103	249	28.6	Beta	有影响Influential	L	[54-56]
EBV	BBRF2	278	31.2	Gamma	未报道Unreported	未报道Unreported	[57]
KSHV	ORF42	278	31.2	Gamma	有影响Influential	L	[30]

蛋白种类 Protein kinds	功能 Function	参考文献 Reference
HSV-1 pUL7	pUL7影响病毒的复制和毒力，pUL7参与α-4基因的转录激活或调控，pUL7与ANT2相互作用，pUL7与UL51相互作用并定位于黏着斑和高尔基体反面网状结构，pUL7-UL51复合物能有效地促进二次囊膜包被，从而利于病毒的传播。	[23, 60, 75, 88]
HSV-2 pUL7	pUL7影响病毒复制。	[28]
DPV pUL7	pUL7与pUL51相互作用，pUL7定位于细胞质，与pUL51在细胞质和细胞核中共定位。	[52]
PRV pUL7	pUL7影响病毒复制，参与病毒释放，调节神经毒性。	[49]
BHV-1 pUL7	pUL7影响病毒复制和释放。	[50]
VZV pORF53	pORF53与pORF7在转染和感染细胞中相互作用，并在VZV感染细胞的TGN区共定位。二者可能在感染中形成功能复合体，参与VZV致病机制。	[48]
HCMV pUL103	pUL103控制着病毒增殖的后期阶段，调节病毒颗粒和致密体从感染细胞中排出。pUL103具有广泛的蛋白质相互作用网络，能够与多种蛋白相互作用(包括pUL22、pUL48、pUL71和IFIT16等)；pUL103可能在病毒传播过程中发挥重要的调控作用。	[29, 54, 84]
KSHV pORF42	pORF42是有效产生病毒颗粒所必需的；pORF42在KSHV中具有促进病毒蛋白表达的功能；pORF42与pORF55相互作用时从细胞核迁移至细胞质；	[30, 58]
EBV pBBRF2	BBRF2基因与病毒感染性有关。pBSRF1能够将pBBRF2招募至细胞质；pBBRF2通过阻止泛素/蛋白酶体依赖性降解途径来稳定pBSRF1。pBBRF2和pBSRF1相互作用并在EBV二次囊膜包被过程中发挥关键作用。	[80, 91]

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