慢性氧化应激对断奶仔猪器官组织微量元素含量的影响

doi:10.11843/j.issn.0366-6964.2025.09.026

畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (9): 4452-4460.doi: 10.11843/j.issn.0366-6964.2025.09.026

慢性氧化应激对断奶仔猪器官组织微量元素含量的影响

覃阳¹^,²(), 夏嗣廷¹, 何流琴³, 王天丽², 刘宇炎³, 姜肖翰³, 刘智豪², 刘思危³, 李铁军²^,*(), 印遇龙¹^,²^,*()

1. 湖南农业大学动物科学技术学院, 长沙 410128
2. 中国科学院亚热带农业生态研究所动物营养生理与代谢过程湖南省重点实验室, 长沙 410125
3. 湖南师范大学生命科学学院动物肠道功能与调控湖南省重点实验室, 长沙 410081

收稿日期:2024-11-19 出版日期:2025-09-23 发布日期:2025-09-30
通讯作者: 李铁军,印遇龙 E-mail:1547558068@qq.com;tjli@isa.ac.cn;yinyulong@isa.ac.cn
作者简介:覃阳(2000-)，男，四川达州人，硕士生，主要从事动物营养与饲料科学研究，E-mail：1547558068@qq.com
基金资助:
广西重点研发计划(桂科AB22035039)；长春市科技发展计划项目(24SH16)；山东省泰山领军人才项目

Effect of Chronic Oxidative Stress on Trace Elements in Organ Tissues of Weaned Piglets

QIN Yang¹^,²(), XIA Siting¹, HE Liuqin³, WANG Tianli², LIU Yuyan³, JIANG Xiaohan³, LIU Zhihao², LIU Siwei³, LI Tiejun²^,*(), YIN Yulong¹^,²^,*()

1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
2. Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
3. Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China

Received:2024-11-19 Online:2025-09-23 Published:2025-09-30
Contact: LI Tiejun, YIN Yulong E-mail:1547558068@qq.com;tjli@isa.ac.cn;yinyulong@isa.ac.cn

摘要/Abstract

摘要：

旨在探究慢性氧化应激对断奶仔猪器官组织微量元素的影响。试验选用12头断奶杜长大三元杂交仔猪，随机平均分为对照组和氧化应激组，每组6头，对照组饲喂基础饲粮，氧化应激组在基础饲粮中额外添加10 g·kg^-1体重剂量的D-半乳糖。试验检测了断奶仔猪器官组织中微量元素含量及其表观消化率。试验结果表明：氧化应激组断奶仔猪肝中Mn的含量、肾中Fe和Mn含量、空肠中Zn含量和结肠中Fe、Cu和Mn含量均显著低于对照组(P＜0.05)；而氧化应激组断奶仔猪肝中Fe和Zn含量、空肠中Fe和Cu含量、回肠中Fe和Cu含量均显著高于对照组(P＜0.05)。与对照组相比，氧化应激组断奶仔猪Cu、Fe和Mn的表观消化率显著降低(P < 0.05)。综上所述，D-半乳糖诱导的慢性氧化应激模型可改变断奶仔猪各器官组织微量元素含量，降低微量元素在仔猪体内的表观消化率。

关键词: 慢性氧化应激, 断奶仔猪, 微量元素

Abstract:

The purpose of this study was to investigate the effects of chronic oxidative stress on trace elements in organs and tissues of weaned piglets. Twelve weaned Duroc×Landrace×Yorkshire crossbred piglets were randomly divided into control group and oxidative stress group, with 6 piglets in each group. The control group was fed a basal diet, and the oxidative stress group was fed the basal diet supplemented with 10 g·kg^-1 body weight dose of D-galactose.The experiment detected the trace elements in the organ tissues of weaned piglets and the apparent digestibility of the trace elements. The results showed that the contents of Mn in liver, Fe and Mn in kidney, Zn in jejunum, Fe, Cu and Mn in colon of weaned piglets in oxidative stress group were significantly lower than those in the control group (P < 0.05). The contents of Fe and Zn in liver, Fe and Cu in jejunum, Fe and Cu in ileum of weaned piglets in oxidative stress group were significantly higher than those in the control group (P < 0.05). Compared with the control group, the apparent digestibility of Cu, Fe and Mn were significantly decreased in oxidative stress group (P < 0.05).In summary, the chronic oxidative stress model induced by D-galactose can change the content of trace elements in various organs and tissues of weaned piglets and reduce the metabolic efficiency of apparent digestibility in piglets.

Key words: chronic oxidative stress, weaned piglets, race elements

中图分类号:

S852.2

覃阳, 夏嗣廷, 何流琴, 王天丽, 刘宇炎, 姜肖翰, 刘智豪, 刘思危, 李铁军, 印遇龙. 慢性氧化应激对断奶仔猪器官组织微量元素含量的影响[J]. 畜牧兽医学报, 2025, 56(9): 4452-4460.

QIN Yang, XIA Siting, HE Liuqin, WANG Tianli, LIU Yuyan, JIANG Xiaohan, LIU Zhihao, LIU Siwei, LI Tiejun, YIN Yulong. Effect of Chronic Oxidative Stress on Trace Elements in Organ Tissues of Weaned Piglets[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4452-4460.

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项目Item	组成Composition
原料Ingredient
膨化玉米Extruded maize	32.00
玉米Corn	31.99
豆粕Soybean meal	14.40
膨化大豆Expanded soybean	7.00
鱼粉Fish meal	3.00
小麦麸Wheat bran	3.00
蔗糖Sucrose	2.00
葡萄糖Glucose	1.00
磷酸氢钙CaHPO₄	0.87
柠檬酸Citric acid	0.80
豆油Bean oil	0.72
赖氨酸盐酸盐Lysine hydrochloride	0.60
预混料Premix¹⁾	0.50
石粉Limestone	0.55
氯化钠NaCl	0.40
氧化锌ZnO	0.30
二氧化钛TiO₂	0.30
蛋氨酸Methionine	0.21
苏氨酸Threonine	0.21
氯化胆碱Choline chloride	0.10
色氨酸Tryptophan	0.05
合计Total	100.00
营养水平Nutritional level²⁾
消化能/(MJ·kg^-1) DE	14.43
粗蛋白质CP	17.01
钙Ca	1.29
总磷Total	0.47
有效磷Available P	0.31
赖氨酸Lys	1.31
苏氨酸Thr	0.83
蛋氨酸+半胱氨酸Met+Cys	0.78
色氨酸Trp	0.22

项目Item	对照组Control group	氧化应激组Oxidative stress group	P值P-value
铁Fe	404.91±20.12	313.38±13.68^**	0.006
锌Zn	240.19±16.21	180.62±18.43^*	0.041
锰Mn	8.95±0.27	10.10±0.31^*	0.022
铜Cu	28.63±2.06	24.06±2.32	0.179

项目Item	对照组Control group	氧化应激组Oxidative stress group	P值P-value
铁Fe	166.27±3.60	150.53±3.39^*	0.013
锌Zn	104.24±2.39	112.98±3.83	0.089
铜Cu	40.05±2.75	47.71±2.33	0.066
锰Mn	6.46±0.18	5.99±0.20^*	0.046

项目Item	对照组Control group	氧化应激组Oxidative stress group	P值P-value
铁Fe	126.20±15.73	188.22±23.34^*	0.049
锌Zn	115.27±5.69	97.71±3.83^*	0.034
铜Cu	9.81±0.21	10.13±0.18	0.282
锰Mn	5.52±0.19	6.20±0.30	0.091

项目Item	对照组Control group	氧化应激组Oxidative stress group	P值P-value
铁Fe	131.29±8.69	155.70±6.20^*	0.044
锌Zn	131. 46±5. 43	119. 51±1. 93	0.052
铜Cu	19.69±1.41	24.29±1.77	0.08
锰Mn	4.59±0.57	4.75±0. 34	0.719

慢性氧化应激对断奶仔猪器官组织微量元素含量的影响

Effect of Chronic Oxidative Stress on Trace Elements in Organ Tissues of Weaned Piglets

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项目Item	对照组Control group	氧化应激组Oxidative stress group	P值 P-value
铁Fe	206. 94±17. 48	134. 14±8. 95^**	0.006
锌Zn	123. 51±11. 05	96. 17±6. 26	0.064
铜Cu	13. 08±0. 75	9.82±0. 81^*	0.018
锰Mn	13. 85±2. 24	6. 27±0. 83^**	0.008

项目Item	对照组Control Group	氧化应激组Oxidative Stress Group	P值P-value
铁Fe	50.78±3.59	27.03±5.52^**	0.005
锌Zn	58.52±4.31	41.66±7.33	0.057
铜Cu	65.90±3.07	22.49±16.22^*	0.030
锰Mn	62.74±3.45	40.01±7.79^*	0.015