非编码RNA在传染性法氏囊病病毒感染中的研究进展

doi:10.11843/j.issn.0366-6964.2024.04.014

摘要/Abstract

摘要： 传染性法氏囊病(infectious bursal disease，IBD)是由传染性法氏囊病病毒(IBD virus, IBDV)引起的急性、高度传染性和免疫抑制性禽类疾病。近年来，随着新型变异毒株的出现，IBDV仍然威胁着全球家禽养殖业的健康发展，宿主和IBDV之间的“战役”似乎永不停息。因此，迫切需要制定一种更全面和更有效的策略来控制该疾病，而深入了解IBDV与宿主之间的相互作用，将有助于开发新型疫苗。非编码RNA(non-coding RNA，ncRNAs)是一类丰富的不编码蛋白质的RNA分子，其中包括微小RNA(microRNAs，miRNAs)、长链非编码RNA(long non-coding RNA，lncRNAs)和环状RNA(circular RNA，circRNAs)。近年来，研究发现ncRNAs广泛参与IBDV与宿主的相互作用过程，在IBDV感染中发挥重要的调控作用。本文阐述了宿主miRNAs、lncRNAs和circRNAs在IBDV感染中的作用，以期为IBDV的感染与致病机制研究提供理论参考和新思路。

关键词: 传染性法氏囊病病毒, 非编码RNA, miRNA, lncRNA, circRNA

Abstract: Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). In recent years, with the emergence of IBDV novel variant strains, IBDV still threatens the poultry industry worldwide. It seems that the battle between host and IBDV will never end. Thus, it is urgent to develop a more comprehensive and effective strategy for the control of this disease. A better understanding of the mechanisms underlying virus-host interactions would be of help in the development of novel vaccines. Noncoding RNA (ncRNAs) are an abundant class of RNAs that do not encode proteins. NcRNAs include microRNA (miRNAs), long noncoding RNA (lncRNAs), circular RNA (circRNAs) and small nuclear RNA (snRNAs). Recently, many studies confirmed that noncoding RNA (ncRNAs) were widely involved in the interaction of IBDV and the host, and played a crucial regulatory role in IBDV infection. This review elaborated the role of miRNAs, lncRNAs, and circRNAs in IBDV infection, which will further provide theoretical guidance and new ideas for the development of novel IBDV vaccines or antiviral drugs.

Key words: infectious bursal disease virus, non-coding RNA, miRNA, lncRNA, circRNA

中图分类号:

S858.315.3

刘伟烨, 黄雪伟. 非编码RNA在传染性法氏囊病病毒感染中的研究进展[J]. 畜牧兽医学报, 2024, 55(4): 1488-1498.

LIU Weiye, HUANG Xuewei. Research Progress of Non-coding RNA in Infectious Bursal Disease Virus Infection[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1488-1498.

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