N6-腺苷甲基化调控脂肪生成的研究进展

doi:10.11843/j.issn.0366-6964.2025.05.001

摘要/Abstract

摘要：

N6-甲基腺嘌呤(N6-methyladenosine, m6A) 修饰是真核mRNA中普遍存在的一种动态可逆修饰, 对脂肪代谢调控具有重要作用。m6A修饰通过调节mRNA的稳定性、剪接、运输及翻译等过程, 参与脂肪细胞分化、脂质合成和分解等生物学过程。本文系统地综述了m6A修饰调控脂肪细胞分化、脂质合成和分解的作用机制, 旨在为调控动物脂质生成、提高肉品质、促进畜牧业发展提供新策略。

关键词: N6-腺苷甲基化, 脂代谢, 脂质生成, 棕色脂肪, 脂噬

Abstract:

N6-methyladenosine (m6A) modification is a widely present dynamic reversible modification in eukaryotic mRNA, which plays an important role in regulating lipid metabolism. m6A modification participates in biological processes such as adipocyte differentiation, lipid synthesis and breakdown, by regulating mRNA stability, splicing, transport, and translation. This article systematically reviews the mechanism of m6A modification in regulating adipocyte differentiation, lipid synthesis and breakdown, aiming to provide new strategies for regulating adipogenesis in animals, improving meat quality and promoting the development of animal husbandry.

Key words: N6-methyladenosine, lipid metabolism, adipogenesis, brown fat, lipophage

中图分类号:

S813.1

周锐, 吴德, 车炼强, 林燕, 冯斌, 方正锋. N6-腺苷甲基化调控脂肪生成的研究进展[J]. 畜牧兽医学报, 2025, 56(5): 1995-2003.

ZHOU Rui, WU De, CHE Lianqiang, LIN Yan, FENG Bin, FANG Zhengfeng. Advances of N6-Adenosine Methylation Regulating Adipogenesis[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(5): 1995-2003.

图/表 2

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