畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (8): 3344-3353.doi: 10.11843/j.issn.0366-6964.2024.08.008
张帆帆1(), 李杰茂2, 谭佳1, 黄江南1, 吴玲1, 韦启鹏1,*(
), 康昭风1,*(
)
收稿日期:
2023-07-25
出版日期:
2024-08-23
发布日期:
2024-08-28
通讯作者:
韦启鹏,康昭风
E-mail:zfanfan0816@163.com;weiqp66@sina.com;kzf18579069658@163.com
作者简介:
张帆帆(1990-),男,江西吉安人,博士,主要从事动物病原学与致病机理研究, E-mail: zfanfan0816@163.com
基金资助:
Fanfan ZHANG1(), Jiemao LI2, Jia TAN1, Jiangnan HUANG1, Ling WU1, Qipeng WEI1,*(
), Zhaofeng KANG1,*(
)
Received:
2023-07-25
Online:
2024-08-23
Published:
2024-08-28
Contact:
Qipeng WEI, Zhaofeng KANG
E-mail:zfanfan0816@163.com;weiqp66@sina.com;kzf18579069658@163.com
摘要:
禽偏肺病毒病是由禽偏肺病毒(avian metapneumovirus, aMPV)引起的一种以急性上呼吸道感染、产蛋和蛋壳质量下降为特征的疾病。aMPV可感染鸡、鸭、鸽等多种禽类,在全世界范围内广泛流行,给养禽业带来了巨大的经济损失。本文从病毒基因组结构及其编码蛋白、流行现状、致病特性、病毒感染诱导的宿主免疫应答以及其诊断技术与疫苗等方面对aMPV进行综述,为今后该疾病的诊断和预防提供科学依据。
中图分类号:
张帆帆, 李杰茂, 谭佳, 黄江南, 吴玲, 韦启鹏, 康昭风. 禽偏肺病毒的研究进展[J]. 畜牧兽医学报, 2024, 55(8): 3344-3353.
Fanfan ZHANG, Jiemao LI, Jia TAN, Jiangnan HUANG, Ling WU, Qipeng WEI, Zhaofeng KANG. Research Progress on Avian Metapneumovirus[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(8): 3344-3353.
图 2
偏肺病毒感染和病毒逃逸机制介导的先天免疫应答模式图 左图:MPV感染后,病毒基因组ssRNA和dsRNA中间体暴露于宿主先天性免疫感应器(细胞质中的RIG-I/MDA5或内质中的Toll样受体TLR3/7/8)。这些免疫传感器的激活启动下游信号级联,诱导IFN-β基因表达。RIG-I/MDA5通过线粒体适配体MAVS传递信号,而TLR则通过TRIF/MyD88传递信号。这两种途径都使用共同的TRAF适配体来激活转录因子。TRAF3作为适配体激活TANK/TBK1/IKKε复合物,使IRF3磷酸化并随后二聚化,而TRAF6则负责激活IKK复合物,使NF-κB的典型抑制剂(IκB)磷酸化。活化的转录因子被转运到细胞核中,驱动IFN-β的表达。右图:IFN-β分泌到细胞外空间并与其同源受体IFNAR结合,激活下游JAK-STAT信号传导。受体相关的酪氨酸激酶Jak1和Tyk2并列,进行自我磷酸化和激活。STAT被招募到酪氨酸激酶上并被磷酸化。磷酸化的STAT1/2与IRF9形成三元复合物ISGF3,ISGF3转位至细胞核,并与ISG基因上游启动子区域的ISRE结合。ISG基因随之表达,在细胞中建立抗病毒状态。OAS是ISG的一个例子,它在检测到dsRNA时会产生2′,5′-寡腺苷酸(2′,5′-A),并激活RNase L裂解病毒RNA以产生更多的RLR配体,这是IFN产生的正反馈机制。红色显示的MPV编码蛋白可在不同的作用点上干预宿主先天免疫信号,是病毒复制和传播的逃避机制"
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