[1] FENG K L. Establishment of early diagnostic method for Haemonchus contortus[D]. Nanjing:Nanjing Agricultural University, 2020. (in Chinese) 冯伉梨. 捻转血矛线虫病早期诊断方法的建立[D]. 南京:南京农业大学, 2020. [2] HUANG Y. Preliminary research on the function and molecular mechanism of Hc-nas-33 involved in the molting process of Haemonchus contortus[D]. Hangzhou:Zhejiang University, 2021. (in Chinese) 黄艳. Hc-nas-33参与捻转血矛线虫蜕皮过程的功能及其分子机制初步研究[D]. 杭州:浙江大学, 2021. [3] WANG C Q, LI F F, ZHANG Z Z, et al. Recent research progress in China on Haemonchus contortus[J]. Front Microbiol, 2017, 8:1509. [4] ZHAO X C. Preliminary study on immune responses induced by exosomes from Haemonchus contortus in goat[D]. Beijing:Chinese Academy of Agricultural Sciences, 2018. (in Chinese) 赵小超. 辐照捻转血矛线虫外泌体诱导羊免疫应答的初步研究[D]. 北京:中国农业科学院, 2018. [5] XU S S. Epidemiology, clinical signs and control measures of Haemonchus contortus disease in sheep[J]. Modern Animal Husbandry Science and Technology, 2021(5):133-134. (in Chinese) 徐绍山. 羊捻转血矛线虫病的流行病学、临床症状及防治措施[J]. 现代畜牧科技, 2021(5):133-134. [6] MUCHIUT S M, FERNÁNDEZ A S, STEFFAN P E, et al. Anthelmintic resistance:management of parasite refugia for Haemonchus contortus through the replacement of resistant with susceptible populations[J]. Vet Parasitol, 2018, 254:43-48. [7] KOTZE A C, PRICHARD R K. Anthelmintic resistance in Haemonchus contortus:history, mechanisms and diagnosis[J]. Adv Parasitol, 2016, 93:397-428. [8] NICIURA S C M, TIZIOTO P C, MORAES C V, et al. Extreme-QTL mapping of monepantel resistance in Haemonchus contortus[J]. Parasit Vectors, 2019, 12(1):403. [9] FENG X P, HAYASHI J, BEECH R N, et al. Study of the nematode putative GABA type-A receptor subunits:evidence for modulation by ivermectin[J]. J Neurochem, 2002, 83(4):870-878. [10] RIVIERE J E, PAPICH M G. Veterinary pharmacology and therapeutics[M]. 9th ed. Ames:Wiley-Blackwell, 2009. [11] WOLSTENHOLME A J, ROGERS A T. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics[J]. Parasitology, 2005, 131 Suppl:S85-S95. [12] BLACKHALL W J, PRICHARD R K, BEECH R N. Selection at a γ-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins[J]. Mol Biochem Parasitol, 2003, 131(2):137-145. [13] FOSTER J, COCHRANE E, KHATAMI M H, et al. A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus:agonist recognition in the nematode GABA receptor family[J]. Int J Parasitol Drugs Drug Resist, 2018, 8(3):534-539. [14] COCHRANE E, FOSTER J, KHATAMI M H, et al. Characterization of adjacent charged residues near the agonist binding site of the nematode UNC-49 GABA receptor[J]. Mol Biochem Parasitol, 2022, 252:111521. [15] SIDDIQUI S Z, BROWN D D R, RAO V T S, et al. An UNC-49 GABA receptor subunit from the parasitic nematode Haemonchus contortus is associated with enhanced GABA sensitivity in nematode heteromeric channels[J]. J Neurochem, 2010, 113(5):1113-1122. [16] BROWN D D R, SIDDIQUI S Z, KAJI M D, et al. Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49:modulation by macrocyclic lactone anthelmintics and a receptor for piperazine[J]. Vet Parasitol, 2012, 185(2-4):201-209. [17] HERNANDO G, BOUZAT C. Caenorhabditis elegans neuromuscular junction:GABA receptors and ivermectin action[J]. PLoS One, 2014, 9(4):e95072. [18] CULLY D F, VASSILATIS D K, LIU K K, et al. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans[J]. Nature, 1994, 371(6499):707-711. [19] MARTIN R J, MURRAY I, ROBERTSON A P, et al. Anthelmintics and ion-channels:after a puncture, use a patch[J]. Int J Parasitol, 1998, 28(6):849-862. [20] ATIF M, SMITH J J, ESTRADA-MONDRAGON A, et al. GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance[J]. PLoS Pathog, 2019, 15(1):e1007570. [21] WOLSTENHOLME A J, FAIRWEATHER I, PRICHARD R, et al. Drug resistance in veterinary helminths[J]. Trends Parasitol, 2004, 20(10):469-476. [22] LI B, FENG Y L, YANG X Y, et al. Analysis of glutamtae-gated channel gbr-2 gene from Haemonchus contortus with ivermectin resistance[J]. Chinese Journal of Veterinary Medicine, 2015, 51(1):11-13. (in Chinese) 李斌, 冯伊莉, 杨晓野, 等. 耐伊维菌素捻转血矛线虫谷氨酸门控氯离子通道gbr-2基因分析[J]. 中国兽医杂志, 2015, 51(1):11-13. [23] DENT J A, SMITH M M, VASSILATIS D K, et al. The genetics of ivermectin resistance in Caenorhabditis elegans[J]. Proc Natl Acad Sci U S A, 2000, 97(6):2674-2679. [24] EVANS K S, WIT J, STEVENS L, et al. Two novel loci underlie natural differences in Caenorhabditis elegans abamectin responses[J]. PLoS Pathog, 2021, 17(3):e1009297. [25] XU Y, CHEN G F, XIONG T, et al. Research progress of P-glycoprotein induction[J]. Journal of China Pharmaceutical University, 2018, 49(1):26-33. (in Chinese) 许悦, 陈根富, 熊涛, 等. P-糖蛋白诱导作用的研究进展[J]. 中国药科大学学报, 2018, 49(1):26-33. [26] MATE L, BALLENT M, CANTÓN C, et al. ABC-transporter gene expression in ivermectin-susceptible and resistant Haemonchus contortus isolates[J]. Vet Parasitol, 2022, 302:109647. [27] XU M, MOLENTO M, BLACKHALL W, et al. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog[J]. Mol Biochem Parasitol, 1998, 91(2):327-335. [28] RAZA A, BAGNALL N H, JABBAR A, et al. Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro[J]. Parasit Vectors, 2016, 9(1):522. [29] YAN R F, URDANETA-MARQUEZ L, KELLER K, et al. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans[J]. Vet Parasitol, 2012, 190(3/4):519-529. [30] SENGTHONG C, YINGKLANG M, INTUYOD K, et al. Repeated ivermectin treatment induces ivermectin resistance in Strongyloides ratti by upregulating the expression of ATP-binding cassette transporter genes[J]. Am J Trop Med Hyg, 2021, 105(4):1117-1123. [31] ARDELLI B F, GUERRIERO S B, PRICHARD R K. Ivermectin imposes selection pressure on P-glycoprotein from Onchocerca volvulus:linkage disequilibrium and genotype diversity[J]. Parasitology, 2006, 132(3):375-386. [32] JANSSEN I J I, KRÜCKEN J, DEMELER J, et al. Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans[J]. Int J Parasitol Drugs Drug Resist, 2015, 5(2):44-47. [33] GODOY P, CHE H, BEECH R N, et al. Characterization of Haemonchus contortus P-glycoprotein-16 and its interaction with the macrocyclic lactone anthelmintics[J]. Mol Biochem Parasitol, 2015, 204(1):11-15. [34] RAZA A, KOPP S R, BAGNALL N H, et al. Effects of in vitro exposure to ivermectin and levamisole on the expression patterns of ABC transporters in Haemonchus contortus larvae[J]. Int J Parasitol Drugs Drug Resist, 2016, 6(2):103-115. [35] KELLEROVÁ P, MATOUŠKOVÁ P, LAMKA J, et al. Ivermectin-induced changes in the expression of cytochromes P450 and efflux transporters in Haemonchus contortus female and male adults[J]. Vet Parasitol, 2019, 273:24-31. [36] PACHECO P A, LOUVANDINI H, GIGLIOTI R, et al. Phytochemical modulation of P-Glycoprotein and its gene expression in an ivermectin-resistant Haemonchus contortus isolate in vitro[J]. Vet Parasitol, 2022, 305:109713. [37] HE F, BHUTTO Z, GUO L, et al. Effect of quercetin on P-glycoprotein expression and efflux function in liver and jejunum of rat[J]. Acta Veterinaria et Zootechnica Sinica, 2018, 49(2):422-431. (in Chinese) 何方, BHUTTO Z, 郭荔, 等. 槲皮素对大鼠肝和空肠P-糖蛋白表达及外排功能的影响[J]. 畜牧兽医学报, 2018, 49(2):422-431. [38] ALVAREZ L, SUAREZ G, CEBALLOS L, et al. Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels[J]. Vet Parasitol, 2015, 210(1/2):53-63. [39] ÁSBJÖRNSDÓTTIR K H, MEANS A R, WERKMAN M, et al. Prospects for elimination of soil-transmitted helminths[J]. Curr Opin Infect Dis, 2017, 30(5):482-488. [40] MEECH R, HU D G, MCKINNON R A, et al. The UDP-glycosyltransferase (UGT) superfamily:new members, new functions, and novel paradigms[J]. Physiol Rev, 2019, 99(2):1153-1222. [41] MATOUŠKOVÁ P, VOKŘÁL I, LAMKA J, et al. The role of xenobiotic-metabolizing enzymes in anthelmintic deactivation and resistance in helminths[J]. Trends Parasitol, 2016, 32(6):481-491. [42] MATOUŠKOVÁ P, LECOVÁ L, LAING R, et al. UDP-glycosyltransferase family in Haemonchus contortus:phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences[J]. Int J Parasitol Drugs Drug Resist, 2018, 8(3):420-429. [43] LIU Y. Analysis of transcriptomics and proteomics and functional reseach of IVM-resistant candidate genes in Haemonchus contortus[D]. Hohhot:Inner Mongolia Agricultural University, 2020. (in Chinese) 刘阳. 捻转血矛线虫转录组和蛋白组学分析及耐IVM候选基因功能研究[D]. 呼和浩特:内蒙古农业大学, 2020. [44] ALGUSBI S, KRÜCKEN J, RAMVNKE S, et al. Analysis of putative inhibitors of anthelmintic resistance mechanisms in cattle gastrointestinal nematodes[J]. Int J Parasitol, 2014, 44(9):647-658. [45] WANG W L, SU Q, ZHAO X L, et al. Bioinformation analysis and prokaryotic expression of Haemonchus contortus of P450 gene related to drug resistance[J]. Chinese Journal of Preventive Veterinary Medicine, 2020, 42(11):1181-1184. (in Chinese) 王文龙, 苏倩, 赵学亮, 等. 捻转血矛线虫耐药相关基因P450原核表达及其生物信息学分析[J]. 中国预防兽医学报, 2020, 42(11):1181-1184. [46] FREEMAN A S, NGHIEM C, LI J, et al. Amphidial structure of ivermectin-resistant and susceptible laboratory and field strains of Haemonchus contortus[J]. Vet Parasitol, 2003, 110(3/4):217-226. [47] URDANETA-MARQUEZ L, BAE S H, JANUKAVICIUS P, et al. A dyf-7 haplotype causes sensory neuron defects and is associated with macrocyclic lactone resistance worldwide in the nematode parasite Haemonchus contortus[J]. Int J Parasitol, 2014, 44(14):1063-1071. [48] MÉNEZ C, ALBERICH M, KANSOH D, et al. Acquired tolerance to ivermectin and moxidectin after drug selection pressure in the nematode Caenorhabditis elegans[J]. Antimicrob Agents Chemother, 2016, 60(8):4809-4819. [49] ELMAHALAWY S T, HALVARSSON P, SKARIN M, et al. Genetic variants in dyf-7 validated by droplet digital PCR are not drivers for ivermectin resistance in Haemonchus contortus[J]. Int J Parasitol Drugs Drug Resist, 2018, 8(2):278-286. [50] ZEMKOVA H, TVRDONOVA V, BHATTACHARYA A, et al. Allosteric modulation of ligand gated ion channels by ivermectin[J]. Physiol Res, 2014, 63 Suppl 1(Suppl 1):S215-S224. [51] HABIBI S, NAZARETH K, NICHOLS J, et al. The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel[J]. Int J Parasitol Drugs Drug Resist, 2023, 22:20-26. [52] JELÍNKOVÁ I, YAN Z H, LIANG Z D, et al. Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation[J]. Biochem Biophys Res Commun, 2006, 349(2):619-625. [53] CODDOU C, STOJILKOVIC S S, HUIDOBRO-TORO J P. Allosteric modulation of ATP-gated P2X receptor channels[J]. Rev Neurosci, 2011, 22(3):335-354. [54] DE LOURDES MOTTIER M, PRICHARD R K. Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus[J]. Pharmacogenet Genomics, 2008, 18(2):129-140. [55] LUO X P, LI J Y, GAO W. Polymorphism analysis of candidate genes for ivermectin resistance in Haemonchus contortus[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(4):536-539, 544. (in Chinese) 罗晓平, 李军燕, 高娃, 等. 捻转血矛线虫耐伊维菌素候选基因的多态性分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(4):536-539, 544. [56] TUERSONG W, LIU X, WANG Y F, et al. Comparative metabolome analyses of ivermectin-resistant and-susceptible strains of Haemonchus contortus[J]. Animals (Basel), 2023, 13(3):456. [57] TUERSONG W, ZHOU C X, WU S M, et al. Comparative analysis on transcriptomics of ivermectin resistant and susceptible strains of Haemonchus contortus[J]. Parasit Vectors, 2022, 15(1):159. [58] WANG J Y, YANG Y, MA Y J, et al. Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma[J]. Biomed Pharmacother, 2020, 121:109627. [59] HONG S C, GUO Q, WANG W J, et al. Identification of differentially expressed microRNAs in Culex pipiens and their potential roles in pyrethroid resistance[J]. Insect Biochem Mol Biol, 2014, 55:39-50. [60] ROBINSON E K, COVARRUBIAS S, CARPENTER S. The how and why of lncRNA function:an innate immune perspective[J]. Biochim Biophys Acta Gene Regul Mech, 2020, 1863(4):194419. [61] SEBASTIAN-DELACRUZ M, GONZALEZ-MORO I, OLAZAGOITIA-GARMENDIA A, et al. The role of lncRNAs in gene expression regulation through mRNA stabilization[J]. Noncoding RNA, 2021, 7(1):3. [62] HAENISCH S, CASCORBI I. miRNAs as mediators of drug resistance[J]. Epigenomics, 2012, 4(4):369-381. [63] ETEBARI K, AFRAD M H, TANG B, et al. Involvement of microRNA miR-2b-3p in regulation of metabolic resistance to insecticides in Plutella xylostella[J]. Insect Mol Biol, 2018, 27(4):478-491. [64] GILLAN V, MAITLAND K, LAING R, et al. Increased expression of a MicroRNA correlates with anthelmintic resistance in parasitic nematodes[J]. Front Cell Infect Microbiol, 2017, 7:452. [65] WEN H F, ZHANG Y M, ZHANG H L, et al. Transcriptomic analysis of miRNAs between ivermectin sensitive and resistant strains of Haemonchus contortus[J]. Chinese Journal of Preventive Veterinary Medicine, 2023, 45(3):245-252. (in Chinese) 温海峰, 张艳敏, 张海龙, 等. 捻转血矛线虫伊维菌素敏感虫株与耐药虫株差异miRNA的转录组学分析[J]. 中国预防兽医学报, 2023, 45(3):245-252. [66] MARKS N D, WINTER A D, GU H Y, et al. Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development[J]. Sci Rep, 2019, 9(1):17594. [67] ISIK M, BLACKWELL T K, BEREZIKOV E. MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans[J]. Sci Rep, 2016, 6:36766. [68] CHEN X D, WANG T Y, LIU C X, et al. Analysis of long non-coding RNAs associated with ivermectin resistance and its regulatory function in Haemonchus contortus[J]. Journal of China Agricultural University, 2023, 28(1):190-202. (in Chinese) 陈昕迪, 王腾宇, 刘春霞, 等. 捻转血矛线虫伊维菌素耐药相关长链非编码RNA及其调控功能分析[J]. 中国农业大学学报, 2023, 28(1):190-202. [69] KUMAR D, HU X L, GUO R, et al. Long noncoding RNA:disclosing new horizon in the molecular world of insects[M]//KUMAR D, GONG C L. Trends in Insect Molecular Biology and Biotechnology. Cham:Springer, 2018:85-102. [70] ETEBARI K, FURLONG M J, ASGARI S. Genome wide discovery of long intergenic non-coding RNAs in diamondback moth (Plutella xylostella) and their expression in insecticide resistant strains[J]. Sci Rep, 2015, 5:14642. [71] LIU F L, GUO D H, YUAN Z T, et al. Genome-wide identification of long non-coding RNA genes and their association with insecticide resistance and metamorphosis in diamondback moth, Plutella xylostella[J]. Sci Rep, 2017, 7(1):15870. [72] VALENZUELA-MIRANDA D, ETEBARI K, ASGARI S, et al. Long noncoding RNAs:unexplored players in the drug response of the sea louse Caligus rogercresseyi[J]. Agri Gene, 2017, 4:1-7. [73] VALENZUELA-MUÑOZ V, VALENZUELA-MIRANDA D, GALLARDO-ESCÁRATE C. Comparative analysis of long non-coding RNAs in Atlantic and Coho salmon reveals divergent transcriptome responses associated with immunity and tissue repair during sea lice infestation[J]. Dev Comp Immunol, 2018, 87:36-50. [74] NÚÑEZ-ACUÑA G, SÁEZ-VERA C, VALENZUELA-MUÑOZ V, et al. Tackling the molecular drug sensitivity in the sea louse Caligus rogercresseyi based on mRNA and lncRNA interactions[J]. Genes (Basel), 2020, 11(8):857. [75] NÚÑEZ-ACUÑA G, VALENZUELA-MUÑOZ V, VALENZUELA-MIRANDA D, et al. Comprehensive transcriptome analyses in sea louse reveal novel delousing drug responses through MicroRNA regulation[J]. Mar Biotechnol (NY), 2021, 23(5):710-723. |