猪链球菌耐药现状分析及感染防控措施

doi:10.11843/j.issn.0366-6964.2023.12.004

摘要/Abstract

摘要： 猪链球菌(Streptococcus suis,S. suis)感染长期困扰我国养猪业的健康和可持续性发展,尤其耐药性菌株的出现阻断原本的链球菌病防治策略。针对近年来国内外S. suis的耐药性流行情况的总结,可以为防治S. suis感染提供有效措施。因此,作者首先总结近五年来在国内外多个地区规模化猪场S. suis感染情况(阳性率普遍>40%),其中我国各省市中流行范围最广的是血清2型菌株。随后,作者归纳了猪场中耐药性S. suis流行现状及其感染特点,发现规模化猪场中的耐药性S. suis集中出现在亚洲大陆以及欧洲且多数地区耐药性高达80%以上,以四环素类耐药菌株为主。而我国规模化猪场中耐药性S. suis主要以四环素类和大环内酯类耐药为主。此外,S. suis是人畜共患的病原,可以经呼吸道和血液造成全身感染。最后,针对S. suis菌株变异多的特点,作者提出了精准检测对于防控S. suis感染的重要性并总结了目前常用的快速检测手段。强调以疫苗接种为主的防控手段和联合用药及宿主导向的新型抗菌药物研发的防治措施,为后续S. suis的耐药性菌株感染的防治提供数据支撑。

关键词: 猪链球菌, 耐药性现状, 防治措施

Abstract: Streptococcus suis (S. suis) infection has long plagued the health and sustainable development of our pig industry. In particular, the emergence of drug-resistant strains will block the original prevention and control strategy of streptococcosis. The summary of the prevalence of resistance to S. suis at China and abroad in recent years can provide effective measures for the prevention and treatment of S. suis infection. Therefore, we first summarized the S. suis infection situation in large-scale pig farms at home and abroad in the past five years (most positive rate>40%). Among them, the serotype 2 strain is the most widespread in all provinces and cities in China. Subsequently, we summarized the epidemic status and infection characteristics of drug-resistant S. suis in pig farms, and found that drug-resistant S. suis in large-scale pig farms concentrated in the Asian and Europe, and the drug resistance exceeded 80% in the most regions, mainly tetracycline resistant strains. However, resistance to S. suis in large-scale pig farms in our country is mainly tetracycline and macrolide resistance. In addition, S. suis is a zoonotic agent that can cause systemic infection through the respiratory tract and blood. Finally, in view of the characteristics of S. suis strain variation, we proposed the importance of accurate detection for the prevention and control of S. suis, summarized the rapid detection methods. The prevention and control measures based on vaccination, combined drug use and the development of new host-directed antibiotics are emphasized to provide data support for the subsequent prevention and control of resistant strains of S. suis.

Key words: Streptococcus suis, drug resistance, prevention and control measures

中图分类号:

S852.611

吕若一, 司晓慧, 孙志刚, 史晓敏, 刘晓晔. 猪链球菌耐药现状分析及感染防控措施[J]. 畜牧兽医学报, 2023, 54(12): 4920-4933.

Lü Ruoyi, SI Xiaohui, SUN Zhigang, SHI Xiaomin, LIU Xiaoye. Drug Resistance Situation of Streptococcus suis and Prevention Measures of Infections[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 4920-4933.

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