痒螨病皮肤损伤机制研究进展

doi:10.11843/j.issn.0366-6964.2025.07.010

摘要/Abstract

摘要：

痒螨病是危害全球家养和野生动物的严重外寄生虫病，其主要以皮肤损伤为主要病变特征，弄清皮肤损伤形成特点及其发生机制是寻求痒螨防控新方法的关键。因此，本文系统综述了痒螨病皮肤损伤区域的病变特征，皮肤物理屏障和免疫屏障的受损变化，以及造成这些变化的潜在因素：痒螨的机械运动和其排泄分泌蛋白(PsoES)可导致皮肤物理屏障受损，而排泄分泌蛋白中的过敏原等活性分子可经受损的皮肤物理屏障渗入，引发皮肤免疫屏障紊乱，从而加速皮肤损伤的形成与发展。本文旨在为新型抗螨药物的研发提供方向和参考，以期为痒螨病的防控提供新视角。

关键词: 痒螨病, 皮肤损伤, 皮肤损伤形成因素

Abstract:

Psoroptic mange, a prevalent ecto-parasitic disease affecting domestic and wild animals globally, is primarily characterized by skin lesions. Understanding the characteristics and mechanisms underlying these skin lesions is crucial for developing novel measures against psoroptic mange. This paper systematically reviews the pathological manifestations of skin lesions in psoroptic mange, focusing on the perturbations in the skin's physical and immune barriers during disease progression. Potential factors contributing to these alterationss are discussed, including the mechanical activity of Psoroptes mites and their excretory-secretory proteins (PsoES) which can impair the skin 's physical barrier. Additionally, allergenic and other bioactive molecules within the PsoES can infiltrate the weakened physical barrier, disrupting the immune barrier and thereby accelerating the onset and and progression of skin damage. The objective of this review is to provide insights and directional guidance for the development of novel anti-mite therapeutics, ultimately aiming to provide new perfectives on the prevention and control of psoropic mange.

Key words: psoroptic mange, skin lesion, causative factors of skin lesion

中图分类号:

S855.9

樊洁, 古小彬. 痒螨病皮肤损伤机制研究进展[J]. 畜牧兽医学报, 2025, 56(7): 3142-3151.

FAN Jie, GU Xiaobin. Advances in Research on Skin Lesion of Psoroptic Mange[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(7): 3142-3151.

图/表 3

参考文献 66

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