单独肌内注射阿法沙龙或联用右美托咪定对猫麻醉效果及超声心动图的影响

doi:10.11843/j.issn.0366-6964.2023.11.032

摘要/Abstract

摘要： 旨在探讨单独肌内注射临床有效剂量的阿法沙龙或与低剂量右美托咪定联用对健康猫的麻醉效果和超声心动图的影响。试验前测定超声心动图与生理指标基值。8只试验猫分别肌内注射阿法沙龙 (5 mg·kg^-1,ALF)、右美托咪定 (5 μg·kg^-1,DEX)或二者同时使用 (DEX+ALF),每种处理间隔2周。麻醉后即刻0 (T0)、5 (T5)、10 (T10)、15 (T15)、20 (T20)、25 (T25) 和30 (T30) min测量生理指标。在T15进行超声心动图检查。T30后,DEX 和 DEX+ALF组肌肉注射阿替美唑 (25 μg·kg^-1),并记录试验猫抬头 (LH)、胸骨卧位 (SRr) 和站立 (S) 所需时间。结果显示:DEX+ALF恢复时间较短。与基值相比,ALF组呼吸频率降低,心率升高,但超声心动图的结果无显著变化。DEX组呼吸频率和心率显著降低,超声心动图的结果受到显著影响。DEX+ALF组的结果与DEX组相似。3种麻醉方案均可达到良好的麻醉效果。单独使用阿法沙龙不影响超声心动图参数,但单独使用右美托咪定或联用阿法沙龙均对超声心动图参数有显著抑制作用。

关键词: 猫, 麻醉, 阿法沙龙, 右美托咪定, 超声心动图

Abstract: This study aimed to investigate the effects of administration intramuscularly of alfaxalone with or without dexmedetomidine, on the sedative effect and echocardiographic measurement in healthy cats. Baseline values of echocardiography and physiological indicators were determined before the experiment. Eight cats were intramuscularly injected with alfaxalone (5 mg·kg^-1, ALF), dexmedetomidine (5 μg·kg^-1 DEX) or both (DEX+ALF). The washout period was 2 weeks. Physiological indicators were measured immediately after anesthesia 0 (T0), 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25) and 30 (T30) mins after the sedation effect was achieved. Echocardiography was performed at T15. After T30, the DEX and DEX+ALF groups were intramuscularly injected with atipamezole (25 μg·kg^-1). Times for cats to head-lift (LH), sternal recumbency (SRr), and standing position (ST) were recorded. The recovery time of DEX+ALF was shorter. Compared with the baseline value, alfaxalone decreased the respiratory rate and increased the heart rate of the cats, but did not significantly affect the echocardiographic results. The use of dexmedetomidine significantly reduced respiratory rate and heart rate, depressed the cardiovascular system, and affected the results of echocardiography significantly. The results of the DEX+ALF group were similar to the DEX group. All 3 kinds anesthesia methods could achieve sedative effect. Alfaxalone alone did not significantly affect echocardiographic parameters, but dexmedetomidine strongly depressed cardiovascular function even combined with alfaxalone it was not suitable for anesthesia before echocardiography.

Key words: cat, anesthesia, alfaxalone, dexmedetomidine, echocardiography

中图分类号:

S857.12

郭以哲, 李振东, 赵兴凯, 李帅, 郜航, 周振雷. 单独肌内注射阿法沙龙或联用右美托咪定对猫麻醉效果及超声心动图的影响[J]. 畜牧兽医学报, 2023, 54(11): 4786-4797.

GUO Yizhe, LI Zhendong, ZHAO Xingkai, LI Shuai, GAO Hang, ZHOU Zhenlei. Anesthetic Effects and Echocardiography in Cats following Using Alfaxalone Alone or in Combination with Dexmedetomidine[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4786-4797.

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