环状RNA的生物学功能及其在家禽中的研究进展

doi:10.11843/j.issn.0366-6964.2021.07.002

摘要/Abstract

摘要： 近年来随着高通量测序和生物信息学的发展，环状RNA （circular RNA，circRNA）在生物学领域作为新起之秀备受关注。circRNAs是一种内源性的非编码RNA （non-coding RNA，ncRNAs），通常是由pre-mRNA的反向剪接（back-splicing）而来，形成一个共价闭合环。circRNA在真核细胞中没有自由表达的3'和5'末端，这种特殊的结构使其对核酸外切酶高度不敏感。本文综述了circRNAs的研究简史、种类、可变剪接、生物学功能及在家禽中最新研究进展，为家禽的遗传改良提供新视野。

关键词: 环状 RNA, 可变剪接, 生物学功能, 家禽

Abstract: With the development of high-throughput sequencing and bioinformatics in recent years, as a newcomer, circular RNA (circRNA) has attracted much attention in the field of biology. circRNAs are endogenous non-coding RNAs (ncRNAs) that usually derived from back-splicing of pre-mRNA to form a covalent closed loop. circRNA has no freely expressed 3' and 5' ends in eukaryotic cells, this special structure makes it highly insensitive to exonucleases. This article reviews the brief research history, type, alternative splicing, biological function of circRNA and its latest research progress in poultry to provide new perspectives for genetic improvement of poultry.

Key words: circular RNA, alternative splicing, biological function, poultry

中图分类号:

S813.2

王卫振, 邓占钊, 辛国省, 蔡正云, 顾亚玲, 张娟. 环状RNA的生物学功能及其在家禽中的研究进展[J]. 畜牧兽医学报, 2021, 52(7): 1778-1788.

WANG Weizhen, DENG Zhanzhao, XIN Guosheng, CAI Zhengyun, GU Yaling, ZHANG Juan. The Biological Function of Circular RNA and Its Research Progress in Poultry[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1778-1788.

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