CAF-1在体细胞重编程中的作用机制

doi:10.11843/j.issn.0366-6964.2021.07.001

摘要/Abstract

摘要： 染色质组装因子1（chromatin assembly factor-1，CAF-1），是由p150、p60、p48三个亚单位组成的组蛋白伴侣。CAF-1主要功能是在DNA复制中与增殖细胞核抗原（proliferating cell nuclear antigen，PCNA）相互作用，负责募集组蛋白H3、H4沉积在新合成的DNA上以促进核小体装配。越来越多的研究解析CAF-1复合体的结构及其生物学功能，并发现CAF-1在体细胞重编程过程中发挥重要作用。因此，本文重点介绍了CAF-1的结构、生物学功能和在体细胞重编程中的作用。

关键词: CAF-1, 体细胞重编程, 结构, 功能

Abstract: Chromatin assembly factor-1 (CAF-1) is a histone chaperone composed of 3 subunits(p150, p60, and p48).CAF-1 mainly interacts with proliferating cell nuclear antigen (PCNA) during DNA replication and is responsible for recruiting histones H3 and H4 depositing on newly synthesized DNA to facilitate nucleosome assembly. More and more studies have analyzed the structure and biological function of the CAF-1 complex,and found that CAF-1 plays an important role in the process of somatic cell reprogramming. Therefore, this paper focuses on the structure, biological function and the role of CAF-1 in somatic cell reprogramming.

Key words: CAF-1, somatic cell reprogramming, structure, function

中图分类号:

Q952.6

张迎冰, 于芮峦, 乔培培, 杨莹, 张涌, 苏建民. CAF-1在体细胞重编程中的作用机制[J]. 畜牧兽医学报, 2021, 52(7): 1769-1777.

ZHANG Yingbing, YU Ruiluan, QIAO Peipei, YANG Ying, ZHANG Yong, SU Jianmin. The Mechanism of CAF-1 in Somatic Cell Reprogramming[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1769-1777.

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