伪狂犬病病毒编码的内膜蛋白生物学功能研究进展

doi:10.11843/j.issn.0366-6964.2024.03.010

摘要/Abstract

摘要： 伪狂犬病病毒（pseudorabies virus， PRV）属于甲型疱疹病毒亚科，能够感染宿主神经系统并在神经元中建立潜伏感染，是威胁全球养猪业的重要病原体。与其他甲型疱疹病毒类似，PRV的病毒粒子存在一层富含蛋白质的内膜层，它通过将含有DNA的核衣壳与布满糖蛋白的囊膜层衔接起来构成病毒粒子的完整结构。研究表明，在PRV的感染周期中，内膜蛋白可以通过单独作用或与其他蛋白相互作用的方式，在维持病毒形态结构的稳定、促进病毒的复制和出核、参与病毒在细胞质中的二次包膜、以及对抗宿主免疫系统等方面发挥重要生物学功能。因此本文重点讨论了近年来PRV内膜蛋白生物学功能的相关研究进展，以期为伪狂犬病病毒的病原学研究以及抗病毒研究提供重要参考。

关键词: 伪狂犬病病毒, 内膜蛋白, 生物学功能

Abstract: Pseudorabies virus (PRV) belongs to the α-herpesvirus subfamily, which can infect the host nervous system and establish latent infection in neurons, and PRV is an important pathogen threatening the global swine industry. Similar to other α-herpesviruses, the virion of PRV has a protein-rich inner membrane layer that links the DNA-containing capsids to the glycoprotein filled envelope layer to form the complete structure of the virion. Studies have shown that during the infection cycle of PRV, tegument proteins can play important biological functions in maintaining the stability of the morphological structure of the virus, promoting the replication and nuclear egress of the virus, participating in the secondary envelopment of the virus in the cytoplasm, and fighting against the host immune system by acting alone or interacting with other proteins. Therefore, this paper focuses on the recent research progress on the biological functions of PRV tegument proteins, in order to provide important references for the etiology and antiviral research of pseudorabies virus.

Key words: pseudorabies virus, tegument proteins, biological functions

中图分类号:

S852.659.1

李艺璇, 牛静轶, 李港, 万超, 方仁东, 叶超. 伪狂犬病病毒编码的内膜蛋白生物学功能研究进展[J]. 畜牧兽医学报, 2024, 55(3): 957-970.

LI Yixuan, NIU Jingyi, LI Gang, WAN Chao, FANG Rendong, YE Chao. Research Progress on the Biological Functions of Tegument Proteins Encoded by Pseudorabies Virus[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 957-970.

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