噬菌体的跨黏膜转位以及噬菌体对机体免疫影响的研究进展

doi:10.11843/j.issn.0366-6964.2021.03.003

摘要/Abstract

摘要： 人与动物的微生物群落在黏膜器官分布最多。近年来的研究表明，噬菌体可黏附于黏膜表面从而抵抗病原菌的侵袭；同时，噬菌体还可跨黏膜转位进入机体，并随血液迁移至其他部位的组织器官，进一步引起机体的免疫反应，包括促炎和抗炎反应，从而对机体整体免疫产生影响。机体免疫系统可通过吞噬作用或产生特异性抗体来清除这些进入体内的噬菌体。目前，关于噬菌体转位及进入机体后与免疫系统互作的研究还比较缺乏。本文综述了近些年噬菌体黏附于黏膜并跨黏膜转位进入循环系统以及噬菌体进入机体后对整体免疫影响的研究进展，以期为今后更广泛深入地研究提供参考。

关键词: 噬菌体, 噬菌体转位, 炎症反应, 吞噬作用, 中和抗体

Abstract: The microbial communities of humans and animals are mainly distributed in mucosal organs. Recent studies have shown that bacteriophages can adhere to mucosal surfaces and provide an antimicrobial defense. In the meantime, bacteriophages translocate across the mucosa into the body and migrate with the blood to other tissues and organs, giving rise to the body's immune response and affecting systemic immunity. However, these endogenous bacteriophages can be eliminated through phagocytosis or specific antibodies. At present, there is still a lack of research on phage translocation and interaction with the immune system after entering the body. Here we review recent researches on bacteriophages adhering to the mucosa and translocating into the circulatory system, as well as the effect of endogenous bacteriophages on systemic immunity. This review may provide a reference for more extensive and in-depth studies in the future.

Key words: bacteriophage, bacteriophage translocation, inflammatory response, phagocytosis, neutralizing antibodies

中图分类号:

Q939.48

刘燕坤, 林焱, 朱伟云. 噬菌体的跨黏膜转位以及噬菌体对机体免疫影响的研究进展[J]. 畜牧兽医学报, 2021, 52(3): 588-595.

LIU Yankun, LIN Yan, ZHU Weiyun. Advances in the Bacteriophage Translocation and the Effect of Bacteriophage on the Immunity[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(3): 588-595.

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