干扰素-ε研究进展

doi:10.11843/j.issn.0366-6964.2021.011.004

摘要/Abstract

摘要： 干扰素-ε（IFN-ε）是新发现的一种Ⅰ型干扰素（IFNs），是由多种细胞分泌的一类细胞因子，其本质是一种糖蛋白，可间接发挥抗病毒、免疫调节和抗肿瘤的生物学活性。但与其他Ⅰ型干扰素不同，IFN-ε的产生不需要病毒诱导，其由黏膜上皮细胞组成型表达，并受激素调节，在黏膜免疫中具有重要作用。目前相关研究报道较少，本文就人和不同动物IFN-ε的起源、体内分布规律，以及对生殖系统的保护、神经系统的调节及抗病毒等研究进展进行综述，以便进一步了解和开发新型干扰素。

关键词: 干扰素-ε, 细胞因子, 组成型表达, 抗病毒活性

Abstract: Interferon-epsilon (IFN-ε) is a novel type I interferons (IFNs), which is also a type of cytokines secreted by varieties of cells. It is a glycoprotein, which can exert antiviral, immunoregulatory and anti-tumor biological activities. However, unlike other type I IFNs, IFN-ε is constitutively expressed by mucous epithelial cell and regulated by hormones without virus induction. IFN-ε plays an important role in mucosal immunity. At present, there are few reports on related studies. In this paper, we reviewed the research progress of IFN-ε origin of human and different animals, distribution in vivo, protection of reproductive system, regulation of nervous system and antiviral effect, to further understand and develop new IFNs reagent.

Key words: interferon-ε, cytokines, constitutive expression, antiviral activity

中图分类号:

S852.4

张海玲, 廉士珍, 张东亮, 白雪, 章沙沙, 张蕾, 李伟, 刘方圆, 王菡, 胡博, 卢士英. 干扰素-ε研究进展[J]. 畜牧兽医学报, 2021, 52(11): 3023-3029.

ZHANG Hailing, LIAN Shizhen, ZHANG Dongliang, BAI Xue, ZHANG Shasha, ZHANG Lei, LI Wei, LIU Fangyuan, WANG Han, HU Bo, LU Shiying. Research Progress of Interferon-ε[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(11): 3023-3029.

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