猫传染性腹膜炎研究进展

doi:10.11843/j.issn.0366-6964.2020.05.005

摘要/Abstract

摘要： 猫传染性腹膜炎是一种全身性、致死性的病毒性疾病，为幼猫和青年猫死亡的主要原因之一。近年来，该病在世界各地广泛流行，并呈一定的上升趋势。越来越多的学者对其进行了研究与探索，但其致病与免疫机制仍未完全清楚。本文从病原学、发病机制、流行病学、临床症状、诊断与治疗以及免疫与预防等方面对猫传染性腹膜炎进行全面的阐述，为该病的科学诊治与防控提供参考和指导。

关键词: 猫传染性腹膜炎, 流行病学, 临床症状, 诊治, 预防, 猫冠状病毒

Abstract: Feline infectious peritonitis is a systemic fatal viral disease, which is one of the main causes of death in young and young adult cats. In recent years, the disease has been widely prevalent in the world and has shown a certain rising trend. More and more scholars have researched and explored it, but its pathogenesis and immune mechanism have not been completely clear. In this paper, the etiology, pathogenesis, epidemiology, clinical symptoms, diagnosis, and treatment as well as immunity and prevention of feline infectious peritonitis were comprehensively described, providing reference and guidance for the scientific diagnosis, treatment, and prevention of the disease.

Key words: feline infectious peritonitis, epidemiology, clinical symptoms, diagnosis and treatment, prevention, feline coronavirus

中图分类号:

S858.2935.3

尹伊娅, 刘晓雅, 王朝好, 李婷, 胡长敏. 猫传染性腹膜炎研究进展[J]. 畜牧兽医学报, 2020, 51(5): 933-942.

YIN Yiya, LIU Xiaoya, WANG Chaohao, LI Ting, HU Changmin. Advances in Research on Feline Infectious Peritonitis[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(5): 933-942.

参考文献 69

[1]	BANK-WOLF B R, STALLKAMP I, WIESE S, et al. Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis[J]. Vet Microbiol, 2014, 173(3-4):177-188.
[2]	LEWIS C S, PORTER E, MATTHEWS D, et al. Genotyping coronaviruses associated with feline infectious peritonitis[J]. J Gen Virol, 2015, 96(6):1358-1368.
[3]	PEDERSEN N C. A review of feline infectious peritonitis virus infection:1963-2008[J]. J Feline Med Surg, 2009, 11(4):225-258.
[4]	SYKES J E. Canine and feline infectious diseases[M]. Amsterdam:Elsevier Science, 2013:195-208.
[5]	KIM Y, LIU H W, KANKANAMALAGE A C G, et al. Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor[J]. PLoS Pathog, 2016, 12(3):e1005531.
[6]	MURPHY B G, PERRON M, MURAKAMI E, et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies[J]. Vet Microbiol, 2018, 219:226-233.
[7]	PEDERSEN N C, KIM Y, LIU H W, et al. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis[J]. J Feline Med Surg, 2018, 20(4):378-392.
[8]	PEDERSEN N C, PERRON M, BANNASCH M, et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. J Feline Med Surg, 2019, 21(4):271-281.
[9]	唐小娟, 王姗, 尹伊娅, 等. 湖北省武汉市某门诊猫传染性腹膜炎病例统计分析[J]. 中国动物检疫, 2019, 36(4):22-25.TANG X J, WANG S, YIN Y Y, et al. Statistical analysis on cases of feline infectious peritonitis in an animal clinic in Wuhan city of Hubei province[J]. China Animal Health Inspection, 2019, 36(4):22-25. (in Chinese)
[10]	GONZÁLEZ J M, GOMEZ-PUERTAS P, CAVAN-AGH D, et al. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae[J]. Arch Virol, 2003, 148(11):2207-2235.
[11]	KIPAR A, MELI M L. Feline infectious peritonitis:still an enigma?[J]. Vet Pathol, 2014, 51(2):505-526.
[12]	MYRRHA L W, SILVA F M F, DE OLIVEIRA PETERNELLI E F, et al. The paradox of feline coronavirus pathogenesis:a review[J]. Adv Virol, 2011, 2011:109849.
[13]	MALBON A J, MELI M L, BARKER E N, et al. Inflammatory mediators in the mesenteric lymph nodes, site of a possible intermediate phase in the immune response to feline coronavirus and the pathogenesis of feline infectious peritonitis?[J]. J Comp Pathol, 2019, 166:69-86.
[14]	SHIBA N, MAEDA K, KATO H, et al. Differentiation of feline coronavirus type I and II infections by virus neutralization test[J]. Vet Microbiol, 2007, 124(3-4):348-352.
[15]	TILLEY L P, SMITH JR F W K. Blackwell's five-minute veterinary consult:canine and feline[M]. Ames, Iowa:John Wiley and Sons, 2016.
[16]	TEKES G, THIEL H J. Feline coronaviruses:pathogenesis of feline infectious peritonitis[J]. Adv Virus Res, 2016, 96:193-218.
[17]	CHANG H W, DE GROOT R J, EGBERINK H F, et al. Feline infectious peritonitis:insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene[J]. J Gen Virol, 2010, 91(2):415-420.
[18]	PEDERSEN N C, BOYLE J F, FLOYD K, et al. An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis[J]. Am J Vet Res, 1981, 42(3):368-377.
[19]	CHANG H W, EGBERINK H F, HALPIN R, et al. Spike protein fusion peptide and feline coronavirus virulence[J]. Emerg Infect Dis, 2012, 18(7):1089-1095.
[20]	LICITRA B N, MILLET J K, REGAN A D, et al. Mutation in spike protein cleavage site and pathogenesis of feline coronavirus[J]. Emerg Infect Dis, 2013, 19(7):1066-1073.
[21]	BROWN M A, TROYER J L, PECON-SLATTERY J, et al. Genetics and pathogenesis of feline infectious peritonitis virus[J]. Emerg Infect Dis, 2009, 15(9):1445-1452.
[22]	DEDEURWAERDER A, DESMARETS L M, OLYSLAEGERS D A J, et al. The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes[J]. Vet Microbiol, 2013, 162(2-4):447-455.
[23]	PEDERSEN N C, LIU H W, SCARLETT J, et al. Feline infectious peritonitis:role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats[J]. Virus Res, 2012, 165(1):17-28.
[24]	MALBON A J, FONFARA S, MELI M L, et al. Feline infectious peritonitis as a systemic inflammatory disease:contribution of liver and heart to the pathogenesis[J]. Viruses, 2019, 11(12):1144.
[25]	REGAN A D, COHEN R D, WHITTAKER G R. Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells[J]. Virology, 2009, 384(1):135-143.
[26]	KIPAR A, MAY H, MENGER S, et al. Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis[J]. Vet Pathol, 2005, 42(3):321-330.
[27]	TAKANO T, OHYAMA T, KOKUMOTO A, et al. Vascular endothelial growth factor (VEGF), produced by feline infectious peritonitis (FIP) virus-infected monocytes and macrophages, induces vascular permeability and effusion in cats with FIP[J]. Virus Res, 2011, 158(1-2):161-168.
[28]	ADDIE D, HOUE L, MAITLAND K, et al. Effect of cat litters on feline coronavirus infection of cell culture and cats[J/OL]. J Feline Med Surg, 2019:1-8.[2020-03-04]. https://journals.sagepub.com/doi/pdf/10.1177/1098612X19848167.
[29]	STRANIERI A, PROBO M, PISU M C, et al. Preliminary investigation on feline coronavirus presence in the reproductive tract of the tom cat as a potential route of viral transmission[J]. J Feline Med Surg, 2020, 22(2):178-185.
[30]	TEKES G, SPIES D, BANK-WOLF B, et al. A reverse genetics approach to study feline infectious peritonitis[J]. J Virol, 2012, 86(12):6994-6998.
[31]	WORTHING K A, WIGNEY D I, DHAND N K, et al. Risk factors for feline infectious peritonitis in Australian cats[J]. J Feline Med Surg, 2012, 14(6):405-412.
[32]	FOLEY J E, POLAND A, CARLSON J, et al. Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus[J]. J Am Vet Med Assoc, 1997, 210(9):1313-1318.
[33]	RIEMER F, KUEHNER K A, RITZ S, et al. Clinical and laboratory features of cats with feline infectious peritonitis-a retrospective study of 231 confirmed cases (2000-2010)[J]. J Feline Med Surg, 2015, 18(4):348-356.
[34]	GREENE C E. Infectious diseases of the dog and cat[M]. Saunders-Elsevier, 2010:92-108.
[35]	DAVIDSON B J, PALING A C, LAHMERS S L, et al. Disease association and clinical assessment of feline pericardial effusion[J]. J Am Anim Hosp Assoc, 2008, 44(1):5-9.
[36]	NORSWORTHY G D. The feline patient[M]. West Sussex:John Wiley & Sons, 2018:181-183.
[37]	黄欣, 侯忠勇, 李浩运, 等. 非渗出型猫传染性腹膜炎的诊断[J]. 中国兽医杂志, 2018, 54(12):84-85.HUANG X, HOU Z Y, LI H Y, et al. Diagnosis of nonexudative feline infectious peritonitis in[J]. Chinese Journal of Veterinary Medicine, 2018, 54(12):84-85. (in Chinese)
[38]	REDFORD T, AL-DISSI A N. Feline infectious peritonitis in a cat presented because of papular skin lesions[J]. Can Vet J, 2019, 60(2):183-185.
[39]	PEDERSEN N C. An update on feline infectious peritonitis:virology and immunopathogenesis[J]. Vet J, 2014, 201(2):123-132.
[40]	VERMEULEN B L, DEVRIENDT B, OLYSLAEGERS D A, et al. Suppression of NK cells and regulatory T lymphocytes in cats naturally infected with feline infectious peritonitis virus[J]. Vet Microbiol, 2013, 164(1-2):46-59.
[41]	PEDERSEN N C, ECKSTRAND C, LIU H W, et al. Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection[J]. Vet Microbiol, 2015, 175(2-4):157-166.
[42]	HARTMANN K, BINDER C, HIRSCHBERGER J, et al. Comparison of different tests to diagnose feline infectious peritonitis[J]. J Vet Intern Med, 2003, 17(6):781-790.
[43]	CERÓN J J, ECKERSALL P D, MARTÍNEZ-SUBIELA S. Acute phase proteins in dogs and cats:current knowledge and future perspectives[J]. Vet Clin Pathol, 2005, 34(2):85-99.
[44]	SPARKES A H, GRUFFYDD-JONES T J, HARBOUR D A. An appraisal of the value of laboratory tests in the diagnosis of feline infectious peritonitis[J]. J Am Anim Hosp Assoc, 1994, 30:345-350.
[45]	PEDERSEN N C. An update on feline infectious peritonitis:diagnostics and therapeutics[J]. Vet J, 2014, 201(2):133-141.
[46]	HAZUCHOVA K, HELD S, NEIGER R. Usefulness of acute phase proteins in differentiating between feline infectious peritonitis and other diseases in cats with body cavity effusions[J]. J Feline Med Surg, 2017, 19(8):809-816.
[47]	GIORI L, GIORDANO A, GIUDICE C, et al. Performances of different diagnostic tests for feline infectious peritonitis in challenging clinical cases[J]. J Small Anim Pract, 2011, 52(3):152-157.
[48]	DUARTE A, VEIGA I, TAVARES L. Genetic diversity and phylogenetic analysis of Feline Coronavirus sequences from Portugal[J]. Vet Microbiol, 2009, 138(1-2):163-168.
[49]	KENNEDY M A, ABD-ELDAIM M, ZIKA S E, et al. Evaluation of antibodies against feline coronavirus 7b protein for diagnosis of feline infectious peritonitis in cats[J]. Am J Vet Res, 2008, 69(9):1179-1182.
[50]	BENETKA V, KVBBER-HEISS A, KOLODZIEJEK J, et al. Prevalence of feline coronavirus types I and II in cats with histopathologically verified feline infectious peritonitis[J]. Vet Microbiol, 2004, 99(1):31-42.
[51]	LONGSTAFF L, PORTER E, CROSSLEY V J, et al. Feline coronavirus quantitative reverse transcriptase polymerase chain reaction on effusion samples in cats with and without feline infectious peritonitis[J]. J Feline Med Surg, 2017, 19(2):240-245.
[52]	BARKER E N, STRANIERI A, HELPS C R, et al. Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis[J]. Vet Res, 2017, 48:60.
[53]	GUAN X T, LI H, HAN M J, et al. Epidemiological investigation of feline infectious peritonitis in cats living in Harbin, Northeast China from 2017 to 2019 using a combination of an EvaGreen-based real-time RT-PCR and serum chemistry assays[J]. Mol Cell Probes, 2020, 49:101495.
[54]	FELTEN S, WEIDER K, DOENGES S, et al. Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis[J]. J Feline Med Surg, 2017, 19(4):321-335.
[55]	PRATELLI A. Comparison of serologic techniques for the detection of antibodies against feline coronaviruses[J]. J Vet Diagn Invest, 2008, 20(1):45-50.
[56]	MELI M L, BURR P, DECARO N, et al. Samples with high virus load cause a trend toward lower signal in feline coronavirus antibody tests[J]. J Feline Med Surg, 2013, 15(4):295-299.
[57]	SHELLY S M, SCARLETT-KRANZ J, BLUE J T. Protein electrophoresis on effusions from cats as a diagnostic test for feline infectious peritonitis[J]. J Am Anim Hosp Assoc, 1988, 24(5):495-500.
[58]	GIORDANO A, STRANIERI A, ROSSI G, et al. High diagnostic accuracy of the Sysmex XT-2000iV delta total nucleated cells on effusions for feline infectious peritonitis[J]. Vet Clinic Pathol, 2015, 44(2):295-302.
[59]	STRANIERI A, PALTRINIERI S, GIORDANO A. Diagnosing feline infectious peritonitis using the Sysmex XT-2000iV based on frozen supernatants from cavitary effusions[J]. J Vet Diagn Invest, 2017, 29(3):321-324.
[60]	TASKER S. Diagnosis of feline infectious peritonitis:update on evidence supporting available tests[J]. J Feline Med Surg, 2018, 20(3):228-243.
[61]	FISCHER Y, SAUTER-LOUIS C, HARTMANN K. Diagnostic accuracy of the Rivalta test for feline infectious peritonitis[J]. Vet Clin Pathol, 2012, 41(4):558-567.
[62]	FELTEN S, HARTMANN K. Diagnosis of feline infectious peritonitis:a review of the current literature[J]. Viruses, 2019, 11(11):1068.
[63]	FERREIRA A, MARWOOD R, BATCHELOR D, et al. Prevalence and clinical significance of the medullary rim sign identified on ultrasound of feline kidneys[J]. Vet Rec, 2019.[2020-03-04]. https://veterinaryrecord.bmj.com/content/early/2019/11/20/vr.105619.full.
[64]	LEWIS K M, O'BRIEN R T. Abdominal ultrasonographic findings associated with feline infectious peritonitis:a retrospective review of 16 cases[J]. J Am Anim Hosp Assoc, 2010, 46(3):152-160.
[65]	王广龙, 王勇, 戴健涛, 等. 猫传染性腹膜炎研究进展[J]. 黑龙江畜牧兽医, 2018(7):62-65.WANG G L, WANG Y, DAI J T, et al. Advances in research on feline infectious peritonitis[J]. Heilongjiang Animal Science and Veterinary Medicine, 2018(7):62-65. (in Chinese)
[66]	张心怡. 猫传染性腹膜炎的治疗[J]. 中兽医学杂志, 2019(3):89-95.ZHANG X Y. Treatment of feline infectious peritonitis[J]. Chinese Journal of Traditional Veterinary Science, 2019(3):89-95. (in Chinese)
[67]	蒋剑成, 王志慧, 张思瑶, 等. 一例猫传染性腹膜炎的诊断[J]. 黑龙江畜牧兽医, 2018(8):125-127, 234-235.JIANG J C, WANG Z H, ZHANG S Y, et al. Diagnosis of a case of feline infectious peritonitis[J]. Heilongjiang Animal Science and Veterinary Medicine, 2018(8):125-127, 234-235. (in Chinese)
[68]	毛军福, 谢倩茹, 夏兆飞. 146例猫传染性腹膜炎的临床变化与转归[J]. 畜牧与兽医, 2019, 51(10):122-126.MAO J F, XIE Q R, XIA Z F. Clinical changes and outcome of 146 cases of cats with feline infectious peritonitis[J]. Animal Husbandry & Veterinary Medicine, 2019, 51(10):122-126. (in Chinese)
[69]	ADDIE D, BELÁK S, BOUCRAUT-BARALON C, et al. Feline infectious peritonitis:ABCD guidelines on prevention and management[J]. J Feline Med Surg, 2009, 11(7):594-604.