嵴病毒的研究进展

doi:10.11843/j.issn.0366-6964.2023.03.005

摘要/Abstract

摘要： 嵴病毒(kobuvirus, KoV)是微RNA病毒科的一个新的属，目前，KoV有A型爱知病毒~F型爱知病毒6个种，其均为单股正链RNA病毒。该病毒可通过直接或间接接触方式感染人和多种动物，主要临床症状为腹泻。迄今为止，KoV已经在美国、中国、日本、巴基斯坦、巴西、德国、法国、突尼斯等17个国家检出，具有广泛的地域分布。最近，本实验室的研究表明该病毒在我国山羊和藏绵羊中广泛流行，具有独特的进化趋势，并且有新基因型毒株的出现。本文就KoV的基因组结构及其编码蛋白、流行情况、生物学特性、致病机理、检测技术等方面的研究进展进行综述，以期为后续科学研究以及该病的有效防控提供参考。

关键词: 嵴病毒, 病原学, 腹泻, 流行病学, 检测技术

Abstract: Kobuvirus (KoV) is a single-stranded, positive-sense RNA virus in a new genus of the picornavirus family and currently includes 6 species of Aichivirus A-F. KoV can infect humans and animals through direct or indirect contact. The main clinical symptom of infected animals is diarrhea. The virus is widely distributed all over the world. To date, KoV has been detected in 17 countries including the USA, China, Japan, Pakistan, Brazil, Germany, France, Tunisia, etc., suggesting that KoV has been widely distributed around the world. Recently, our studies suggested that the virus has been widely circulating among goats and sheep in China, presenting a unique evolution trend, and new genotypes have been determined. To provide a reference for KoV research, this review describes the latest research progress on KoV, including the genome structure and its coding protein, epidemiology, biological characteristics, pathogenesis and detection methods.

Key words: kobuvirus, etiology, diarrhea, epidemiology, detection technology

中图分类号:

S852.659.6

阿比克哈莫, 汤承, 杨晨, 杨发龙. 嵴病毒的研究进展[J]. 畜牧兽医学报, 2023, 54(3): 900-913.

ABI-kehamo, TANG Cheng, YANG Chen, YANG Falong. Research Advances in Kobuvirus[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 900-913.

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