肌注马波沙星在犊黄牛体内的药动学及半体内抗菌后效应研究

doi:10.11843/j.issn.0366-6964.2015.11.022

Abstract

Abstract:

This experiment was conducted to study the pharmacokinetics parameters of marbofloxacin after single intramuscular administration in infancy yellow cattle and the Post-antibiotic effects（PAE） of marbofloxacin against Pasteurella multocida in serum.Marbofloxacin was administered to 5 healthy infancy yellow cattle at a dose of 2 mg•kg^-1 of body weight，the concentrations of marbofloxacin in serum were determined by high-performance liquid chromatography and marbofloxacin concentration-time data in serum were analyzed using non-compartmental analysis of WinNolin6.2 programme.Furthermore，PAE of marbofloxacin against Pasteurella multocida were tested in serum collected at predetermined time point.The main pharmacokinetic parameters intramuscularly were as follows：C_max=2.04 μg•mL^-1，T_max=0.83 h，AUC=15.03 h•μg•mL^-1，AUMC =138.67 h•h•μg•mL^-1，MRT =9.17 h，t_1/2β=9.00 h，V_d=1.80 L•kg^-1，CL/F= 0.14 L•（h•kg）^-1.The PAE of marbofloxacin against P.multocida at the concentration levels of 2MIC，4MIC，8MIC in serum were 1.90，2.65，3.50 h respectively.It was noted that marbofloxacin was relatively rapidly absorbed，widely distributed and slowly eliminated after intramuscular administration.The PAE of marbofloxacin against P.multocida in serum was obviously prolonged and dependent on concentration.

CLC Number:

S859.7

CAO Chang-fu，SUN Mei-zhen，LU Yan，ZENG Qing-lin，LIU Wei，ZENG Zhen-ling. Pharmacokinetic of Marbofloxacin in Infancy Yellow Cattle after Single Intramuscular Administrations and ex vivo the Post-antibiotic Effects[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(11): 2078-2084.

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Pharmacokinetic of Marbofloxacin in Infancy Yellow Cattle after Single Intramuscular Administrations and ex vivo the Post-antibiotic Effects

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