畜牧兽医学报 ›› 2017, Vol. 48 ›› Issue (3): 393-402.doi: 10.11843/j.issn.0366-6964.2017.03.002

• 综述 • 上一篇    下一篇

牛支原体逃避宿主免疫的研究进展

季文恒,储岳峰*,赵萍,陈胜利,郝华芳,王展慧,刘永生   

  1. (中国农业科学院兰州兽医研究所 家畜疫病病原生物学国家重点实验室,兰州 730046)
  • 收稿日期:2016-08-18 出版日期:2017-03-23 发布日期:2017-03-23
  • 通讯作者: 储岳峰,E-mail:chuyuefeng@caas.cn
  • 作者简介:季文恒(1991-),男,山东临沂人,硕士生,主要从事预防兽医学研究,E-mail:18298466258@163.com
  • 基金资助:

    国家科技支撑计划(2015BAD12B02);国家自然科学基金(31402223;31602088);兰州市城关区科技计划(2012-2-1);科研院所基金(1610312016027)

Advances in the Research of Immune Evasion by Mycoplasma bovis

JI Wen-heng, CHU Yue-feng*, ZHAO Ping, CHEN Sheng-li, HAO Hua-fang,WANG Zhan-hui,LIU Yong-sheng   

  1. (State Key laboratory of Veterinary Etiological Biology /Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China)
  • Received:2016-08-18 Online:2017-03-23 Published:2017-03-23

摘要:

牛支原体(Mycoplasma bovis)是能够感染牛的一种重要的致病性支原体。牛支原体能够在宿主中持续存在并引起慢性疾病,包括肺炎、乳腺炎、耳炎、生殖障碍、关节炎、脑膜炎以及角膜结膜炎。由于临床上抗生素治疗效果不佳以及缺乏商业可用的敏感性诊断工具和有效的疫苗,牛支原体引起的疾病很难预防和控制。牛支原体能够造成长期感染的主要原因是其通过表面抗原高频率变异、规避吞噬细胞吞噬作用、入侵宿主细胞、形成生物膜以及调节宿主免疫应答等方法逃避宿主天然和适应性免疫。深入理解牛支原体的免疫逃避机制有助于研制更好的牛支原体诊断工具和疫苗,也将进一步促进牛支原体预防与控制技术的发展。

Abstract:

Mycoplasma bovis is considered to be one of the important pathogenic agents of cattle. It can persist in the host and causes a series of chronic diseases including bronchopneumonia, mastitis, otitis, genital disorders, arthritis, meningitis or keratoconjunctivitis. Due to the resistance to antibotic therapy and the lake of commercially available diagnostic tools and effective vaccines, M. bovis-induced diseases are difficult to prevent and control. The main reason of persisitent infection caused by M. bovis is to evade the host innate and adaptive immunity through high frequent variation of membrane surface antigens, avoiding phagocytosis, cell invasion, biofilm formation and modulating host immune responses. Deeply understanding immune evasion mechanism of M. bovis is helpful to develop the new dignostic tools and novel vaccines, and it is also beneficial to prevent and control the diseases.

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