卵巢颗粒细胞自噬研究进展

doi:10.11843/j.issn.0366-6964.2025.04.004

Abstract

Abstract:

Ovarian granulosa cells (GCs) are the basic guarantee of follicle development in female animals. In the past, it was widely believed that apoptosis of GCs could regulate follicle development. However, recent studies have found that GCs autophagy can also regulate follicle development. In the animal husbandry industry, the quality of follicle development is closely related to the reproductive rate of female animals, which directly affects the economic benefits of livestock farms. At present, more and more studies have shown that miRNAs are one of the factors regulating autophagy in GCs. Therefore, this article will review the research progress on the origin, structure and function of GCs, the importance of GCs autophagy on the ovary, the miRNAs associated with GCs autophagy of the ovary and their regulatory effects on follicle development, in order to provide references for future related studies.

Key words: ovarian granulosa cells, domestic animals, autophagy, miRNAs

CLC Number:

S814.1

WANG Ying, ZHANG Jiaojiao, WANG Xianzhong, QUAN Fusheng. Advances in Autophagy of Ovarian Granulosa Cells[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(4): 1508-1517.

Figures/Tables 2

Table 1

miRNAs associated with GCs autophagy in female ovaries"

miRNAs	物种Species	靶基因Target gene	功能Function	作用通路Pathway	参考文献Reference
miR-23a	yak	ASK1	promote GCs autophagy and inhibit GCs apoptosis, increase the abundance of estradiol receptor α (ER-α) and β (ER-β) and the concentrations of estradiol (E₂), progesterone (P4) in yak GCs.	lncRNA MEG3/miR-23a /ASK1/JNK pathway	[52, 53]
miR-30a-5p	rat	SOCS3	inhibit autophagy and NLRP3-mediated pyroptosis in GCs.	SOCS3/mTOR/P70S6K pathway	[49]
miR-128-3p, miR-21-5p	chicken	/	regulate GCs autophagy.	/	[54]
miRNA-29-3p	chicken	PTEN	inhibit GCs autophagy and apoptosis.	PTEN/AKT/mTOR pathway	[50]
miR-129-1-3p	laying hens	MCU	promote autophagic death of GCs.	miR-129-1-3p/MCU calcium pathway	[55]
miR-486	guanz--hong dairy goat	SRSF3	promote GCs apoptosis and inhibit GCs proliferation and autophagy.	/	[56]
miR-128-3p	bovine	FOXO4/TFEB	promote GCs autophagy and inhibit GCs apoptosis.	/	[57]
miR-29b-3p	mouse	H19	inhibit GCs autophagy.	H19/miR-29b-3p pathway	[58]
miR-1298-5p	human/rat	GSR	promote GCs autophagy.	/	[59]
miR-654	mouse	STC2	promote apoptosis and autophagy.	lncRNA NEAT1/miR-654/STC2/MAPK pathway	[60]
miR-34a-5p	chicken	LEF1	promote GCs autophagy and apoptosis.	Hippo-YAP signaling pathway	[61]
miR-26b	yak	SMAD1	inhibit GCs proliferation and autophagy and promote apoptosis.	H19/miR-26b/SMAD1 Axis	[62]
miR-146b-3p	chicken	AKT1	promote GCs apoptosis and attenuate autophagy.	PI3K/AKT signaling pathway	[63]
miR-30a-5p	chicken	Beclin1	inhibit GCs autophagy and apoptosis, and promote the synthesis of steroid hormones and increase the level of oxidative stress.	/	[48]
let-7e	human	/	inhibited GCs autophagy and promoted GCs proliferation.	p21signaling pathway	[64]
miR-378d	human	/	regulate GCs autophagy and apoptosis.	/	[65]
miR-21-3p	bovine	FGF2	inhibit GCs autophagy.	AKT/mTOR pathway	[51]
miR-21-3p	bovine	VEGFA	inhibit GCs autophagy.	PI3K/AKT signaling	[66]
let-7g	mouse	IGF-1R	promote GCs autophagy.	IGF1R/AKT/mTOR signaling	[67]

Table 1

Fig. 1

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