HIF-1α在病原体感染中的作用研究进展

doi:10.11843/j.issn.0366-6964.2024.06.008

Abstract

Abstract:

Hypoxia-inducible factor-1α (HIF-1α) is a central regulatory factor in cellular response to hypoxia. Stable HIF-1α has multiple functions and is involved in various biological processes, including angiogenesis, metabolic regulation, autophagy, and apoptosis. The stability of HIF-1α is regulated by multiple signals, including oxygen levels, pathogen infections, and metabolic intermediates. In recent years, increasing evidence has shown that HIF-1α plays an important role in infectious diseases. Therefore, this article discusses and summarizes the regulatory mechanisms of HIF-1α stability and its role in viral, bacterial, and other pathogen infection, as well as in the development of related diseases, aiming to provide references for further study on the role of HIF-1α in defending against various pathogen infections and its potential as a target for targeted therapy.

Key words: HIF-1α, stability, pathogen, infection, mechanism

CLC Number:

S852.4

Zhengyang ZHANG, Yinjuan SONG, Yuefeng CHU. Research Progress on the Role of HIF-1α in Pathogen Infections[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(6): 2357-2367.

Figures/Tables 2

References 75

1	LEE J W , BAE S H , JEONG J W , et al. Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions[J]. Exp Mol Med, 2004, 36 (1): 1- 12. doi: 10.1038/emm.2004.1
2	WEIDEMANN A , JOHNSON R S . Biology of HIF-1α[J]. Cell Death Differ, 2008, 15 (4): 621- 627. doi: 10.1038/cdd.2008.12
3	KE Q D , COSTA M . Hypoxia-inducible factor-1 (HIF-1)[J]. Mol Pharmacol, 2006, 70 (5): 1469- 1480. doi: 10.1124/mol.106.027029
4	WERTH N , BEERLAGE C , ROSENBERGER C , et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens[J]. PLoS One, 2010, 5 (7): e11576. doi: 10.1371/journal.pone.0011576
5	SEMENZA G L . HIF-1 and mechanisms of hypoxia sensing[J]. Curr Opin Cell Biol, 2001, 13 (2): 167- 171. doi: 10.1016/S0955-0674(00)00194-0
6	SEMENZA G L , WANG G L . A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation[J]. Mol Cell Biol, 1992, 12 (12): 5447- 5454.
7	PONTING C P , ARAVIND L . PAS: a multifunctional domain family comes to light[J]. Curr Biol, 1997, 7 (11): R674- R677. doi: 10.1016/S0960-9822(06)00352-6
8	YU F , WHITE S B , ZHAO Q , et al. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation[J]. Proc Natl Acad Sci U S A, 2001, 98 (17): 9630- 9635. doi: 10.1073/pnas.181341498
9	KOIVUNEN P , HIRSILÄ M , REMES A M , et al. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF[J]. J Biol Chem, 2007, 282 (7): 4524- 4532. doi: 10.1074/jbc.M610415200
10	LI F , SONVEAUX P , RABBANI Z N , et al. Regulation of HIF-1α stability through S-nitrosylation[J]. Mol Cell, 2007, 26 (1): 63- 74. doi: 10.1016/j.molcel.2007.02.024
11	KORBECKI J , SIMIŃSKA D , GĄSSOWSKA-DOBROWOLSKA M , et al. Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms[J]. Int J Mol Sci, 2021, 22 (19): 10701. doi: 10.3390/ijms221910701
12	ZAREMBER K A , MALECH H L . HIF-1α: a master regulator of innate host defenses?[J]. J Clin Invest, 2005, 115 (7): 1702- 1704. doi: 10.1172/JCI25740
13	HARTMANN H , ELTZSCHIG H K , WURZ H , et al. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores[J]. Gastroenterology, 2008, 134 (3): 756- 767.e6. doi: 10.1053/j.gastro.2007.12.008
14	MAZZON M , PETERS N E , LOENARZ C , et al. A mechanism for induction of a hypoxic response by vaccinia virus[J]. Proc Natl Acad Sci U S A, 2013, 110 (30): 12444- 12449. doi: 10.1073/pnas.1302140110
15	FRAKOLAKI E , KAIMOU P , MORAITI M , et al. The role of tissue oxygen tension in dengue virus replication[J]. Cells, 2018, 7 (12): 241. doi: 10.3390/cells7120241
16	DESHMANE S L , AMINI S , SEN S , et al. Regulation of the HIV-1 promoter by HIF-1α and Vpr proteins[J]. Virol J, 2011, 8, 477. doi: 10.1186/1743-422X-8-477
17	DUETTE G , PEREYRA GERBER P , RUBIONE J , et al. Induction of HIF-1α by HIV-1 infection in CD4⁺ T cells promotes viral replication and drives extracellular vesicle-mediated inflammation[J]. mBio, 2018, 9 (5): e00757- 18.
18	HAN H K , HAN C Y , CHEON E P , et al. Role of hypoxia-inducible factor-α in hepatitis-B-virus X protein-mediated MDR1 activation[J]. Biochem Biophys Res Commun, 2007, 357 (2): 567- 573. doi: 10.1016/j.bbrc.2007.04.012
19	FARQUHAR M J , HUMPHREYS I S , RUDGE S A , et al. Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication[J]. J Hepatol, 2017, 66 (5): 919- 929. doi: 10.1016/j.jhep.2017.01.009
20	TIAN M F , LIU W Y , LI X , et al. HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19[J]. Signal Transduct Target Ther, 2021, 6 (1): 308. doi: 10.1038/s41392-021-00726-w
21	ZHAO C Q , CHEN J , CHENG L P , et al. Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type Ⅱ epithelial cells[J]. Emerg Microbes Infect, 2020, 9 (1): 691- 706. doi: 10.1080/22221751.2020.1742585
22	REN L H , ZHANG W J , HAN P , et al. Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome[J]. Virology, 2019, 530, 51- 58. doi: 10.1016/j.virol.2019.02.010
23	CRAMER T , YAMANISHI Y , CLAUSEN B E , et al. HIF-1α is essential for myeloid cell-mediated inflammation[J]. Cell, 2003, 112 (5): 645- 657. doi: 10.1016/S0092-8674(03)00154-5
24	PEYSSONNAUX C , DATTA V , CRAMER T , et al. HIF-1α expression regulates the bactericidal capacity of phagocytes[J]. J Clin Invest, 2005, 115 (7): 1806- 1815. doi: 10.1172/JCI23865
25	HUY T X N , NGUYEN T T , REYES A W B , et al. Cobalt (Ⅱ) chloride regulates the invasion and survival of Brucella abortus 544 in RAW 264.7 Cells and B6 Mice[J]. Pathogens, 2022, 11 (5): 596. doi: 10.3390/pathogens11050596
26	GOMES M T R , GUIMARÃES E S , MARINHO F V , et al. STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection[J]. PLoS Pathog, 2021, 17 (5): e1009597. doi: 10.1371/journal.ppat.1009597
27	BRAVERMAN J , SOGI K M , BENJAMIN D , et al. HIF-1α is an essential mediator of IFN-γ-dependent immunity to Mycobacterium tuberculosis[J]. J Immunol, 2016, 197 (4): 1287- 1297. doi: 10.4049/jimmunol.1600266
28	BRAVERMAN J , STANLEY S A . Nitric oxide modulates macrophage responses to Mycobacterium tuberculosis infection through activation of HIF-1α and repression of NF-κB[J]. J Immunol, 2017, 199 (5): 1805- 1816. doi: 10.4049/jimmunol.1700515
29	KNIGHT M , BRAVERMAN J , ASFAHA K , et al. Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense[J]. PLoS Pathog, 2018, 14 (1): e1006874. doi: 10.1371/journal.ppat.1006874
30	MISHRA B B , LOVEWELL R R , OLIVE A J , et al. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis[J]. Nat Microbiol., 2017, 2, 17072. doi: 10.1038/nmicrobiol.2017.72
31	MISHRA B B , RATHINAM V A K , MARTENS G W , et al. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β[J]. Nat Immunol, 2013, 14 (1): 52- 60. doi: 10.1038/ni.2474
32	WYATT E V , DIAZ K , GRIFFIN A J , et al. Metabolic reprogramming of host cells by virulent Francisella tularensis for optimal replication and modulation of inflammation[J]. J Immunol, 2016, 196 (10): 4227- 4236. doi: 10.4049/jimmunol.1502456
33	LATGÉ J P , CHAMILOS G . Aspergillus fumigatus and aspergillosis in 2019[J]. Clin Microbiol Rev, 2019, 33 (1): e00140- 18.
34	SHEPARDSON K M , JHINGRAN A , CAFFREY A , et al. Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection[J]. PLoS Pathog, 2014, 10 (9): e1004378. doi: 10.1371/journal.ppat.1004378
35	FECHER R A , HORWATH M C , FRIEDRICH D , et al. Inverse correlation between IL-10 and HIF-1α in macrophages infected with Histoplasma capsulatum[J]. J Immunol, 2016, 197 (2): 565- 579. doi: 10.4049/jimmunol.1600342
36	FAN D , COUGHLIN L A , NEUBAUER M M , et al. Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization[J]. Nat Med, 2015, 21 (7): 808- 814. doi: 10.1038/nm.3871
37	SHI L B , JIANG Q K , BUSHKIN Y , et al. Biphasic dynamics of macrophage immunometabolism during Mycobacterium tuberculosis infection[J]. mBio, 2019, 10 (2): e02550- 18.
38	GUIMARÃES E S , GOMES M T R , SANCHES R C O , et al. The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during Brucella abortus infection[J]. Front Immunol, 2022, 13, 1063221.
39	GE G , JIANG H Q , XIONG J S , et al. Progress of the art of macrophage polarization and different subtypes in mycobacterial infection[J]. Front Immunol, 2021, 12, 752657. doi: 10.3389/fimmu.2021.752657
40	GLEESON L E , SHEEDY F J , PALSSON-MCDERMOTT E M , et al. Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication[J]. J Immunol, 2016, 196 (6): 2444- 2449. doi: 10.4049/jimmunol.1501612
41	BOWLIN A , ROYS H , WANJALA H , et al. Hypoxia-inducible factor signaling in macrophages promotes lymphangiogenesis in Leishmania major infection[J]. Infect Immun, 2021, 89 (8): e0012421. doi: 10.1128/IAI.00124-21
42	GUO Y , MENG X K , MA J M , et al. Human papillomavirus 16 E6 contributes HIF-1α induced Warburg effect by attenuating the VHL-HIF-1α interaction[J]. Int J Mol Sci, 2014, 15 (5): 7974- 7986. doi: 10.3390/ijms15057974
43	MAZZON M , CASTRO C , ROBERTS L D , et al. A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism[J]. J Gen Virol, 2015, 96 (2): 395- 407. doi: 10.1099/vir.0.069591-0
44	BARRERO C A , DATTA P K , SEN S , et al. HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis[J]. PLoS One, 2013, 8 (7): e68376. doi: 10.1371/journal.pone.0068376
45	REN L H , ZHANG W J , ZHANG J , et al. Influenza a virus (H1N1) infection induces glycolysis to facilitate viral replication[J]. Virol Sin, 2021, 36 (6): 1532- 1542. doi: 10.1007/s12250-021-00433-4
46	MENENDEZ M T , TEYGONG C , WADE K , et al. siRNA screening identifies the host hexokinase 2 (HK2) gene as an important hypoxia-inducible transcription factor 1 (HIF-1) target gene in Toxoplasma gondii-infected cells[J]. mBio, 2015, 6 (3): e00462.
47	SINGH A K , MUKHOPADHYAY C , BISWAS S , et al. Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage[J]. PLoS One, 2012, 7 (6): e38489. doi: 10.1371/journal.pone.0038489
48	COLE A M , SHI J S , CECCARELLI A , et al. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds[J]. Blood, 2001, 97 (1): 297- 304. doi: 10.1182/blood.V97.1.297
49	KELLY C J , GLOVER L E , CAMPBELL E L , et al. Fundamental role for HIF-1α in constitutive expression of human β defensin-1[J]. Mucosal Immunol, 2013, 6 (6): 1110- 1118. doi: 10.1038/mi.2013.6
50	LIN A E , BEASLEY F C , OLSON J , et al. Role of hypoxia inducible factor-1α (HIF-1α) in innate defense against uropathogenic Escherichia coli infection[J]. PLoS Pathog, 2015, 11 (4): e1004818. doi: 10.1371/journal.ppat.1004818
51	ELKS P M , BRIZEE S , VAN DER VAART M , et al. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism[J]. PLoS Pathog, 2013, 9 (12): e1003789. doi: 10.1371/journal.ppat.1003789
52	LI Q , XIE Y Y , CUI Z B , et al. Activation of hypoxia-inducible factor 1 (Hif-1) enhanced bactericidal effects of macrophages to Mycobacterium tuberculosis[J]. Tuberculosis (Edinb), 2021, 126, 102044. doi: 10.1016/j.tube.2020.102044
53	PEYSSONNAUX C , CEJUDO-MARTIN P , DOEDENS A , et al. Cutting edge: essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis1[J]. J Immunol, 2007, 178 (12): 7516- 7519. doi: 10.4049/jimmunol.178.12.7516
54	GRONEBERG M , HOENOW S , MARGGRAFF C , et al. HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis[J]. J Hepatol, 2022, 76 (1): 160- 173. doi: 10.1016/j.jhep.2021.09.020
55	MIZUSHIMA N , KOMATSU M . Autophagy: renovation of cells and tissues[J]. Cell, 2011, 147 (4): 728- 741. doi: 10.1016/j.cell.2011.10.026
56	ZHANG H F , BOSCH-MARCE M , SHIMODA L A , et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia[J]. J Biol Chem, 2008, 283 (16): 10892- 10903. doi: 10.1074/jbc.M800102200
57	DOWDELL A S , CARTWRIGHT I M , GOLDBERG M S , et al. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis[J]. Mol Biol Cell, 2020, 31 (20): 2249- 2258. doi: 10.1091/mbc.E20-05-0291
58	DOWDELL A S , CARTWRIGHT I M , KITZENBERG D A , et al. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination[J]. Cell Rep, 2022, 40 (13): 111409. doi: 10.1016/j.celrep.2022.111409
59	MIMOUNA S , BAZIN M , MOGRABI B , et al. HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC)[J]. Autophagy, 2014, 10 (12): 2333- 2345. doi: 10.4161/15548627.2014.984275
60	FRIEDRICH D , ZAPF D , LOHSE B , et al. The HIF-1α/LC3-Ⅱ axis impacts fungal immunity in human macrophages[J]. Infect Immun, 2019, 87 (7): e00125- 19.
61	NEUBERT P , WEICHSELBAUM A , REITINGER C , et al. HIF1A and NFAT5 coordinate Na⁺-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting[J]. Autophagy, 2019, 15 (11): 1899- 1916. doi: 10.1080/15548627.2019.1596483
62	SOWTER H M , RATCLIFFE P J , WATSON P , et al. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors[J]. Cancer Res, 2001, 61 (18): 6669- 6673.
63	AN W G , KANEKAL M , SIMON M C , et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1α[J]. Nature, 1998, 392 (6674): 405- 408. doi: 10.1038/32925
64	PIRET J P , MOTTET D , RAES M , et al. Is HIF-1α a pro- or an anti-apoptotic protein?[J]. Biochem Pharmacol, 2002, 64 (5/6): 889- 892.
65	LIU X H , YU E Z , LI Y Y , et al. HIF-1α has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression[J]. J Cell Biochem, 2006, 97 (4): 755- 765. doi: 10.1002/jcb.20683
66	MÜHLEISEN A , GIAISI M , KÖHLER R , et al. Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression[J]. Cell Death Dis, 2014, 5 (12): e1575. doi: 10.1038/cddis.2014.536
67	VICTORINO F , BIGLEY T M , PARK E , et al. HIF1α is required for NK cell metabolic adaptation during virus infection[J]. eLife, 2021, 10, e68484. doi: 10.7554/eLife.68484
68	RAJALINGAM K , SHARMA M , LOHMANN C , et al. Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells[J]. PLoS One, 2008, 3 (9): e3102. doi: 10.1371/journal.pone.0003102
69	HAN J , GOLDSTEIN L A , GASTMAN B R , et al. Disruption of Mcl-1 ·Bim complex in Granzyme B-mediated mitochondrial apoptosis[J]. J Biol Chem, 2005, 280 (16): 16383- 16392. doi: 10.1074/jbc.M411377200
70	SHARMA M , MACHUY N , BÖHME L , et al. HIF-1α is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells[J]. Cell Microbiol, 2011, 13 (10): 1573- 1585. doi: 10.1111/j.1462-5822.2011.01642.x
71	MANALO D J , ROWAN A , LAVOIE T , et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1[J]. Blood, 2005, 105 (2): 659- 669. doi: 10.1182/blood-2004-07-2958
72	SAKAI M , TAKAHASHI N , IKEDA H , et al. Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety[J]. Bioorg Med Chem, 2021, 46, 116375. doi: 10.1016/j.bmc.2021.116375
73	CHEN J , LAI L , LIU S , et al. Targeting HIF-1α and VEGF by lentivirus-mediated RNA interference reduces liver tumor cells migration and invasion under hypoxic conditions[J]. Neoplasma, 2016, 63 (6): 934- 940. doi: 10.4149/neo_2016_612
74	ELTZSCHIG H K , BRATTON D L , COLGAN S P . Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases[J]. Nat Rev Drug Discov, 2014, 13 (11): 852- 869. doi: 10.1038/nrd4422
75	AKINSULIE O C , SHAHZAD S , OGUNLEYE S C , et al. Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases[J]. Front Immunol, 2023, 14, 1224102. doi: 10.3389/fimmu.2023.1224102

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Research Progress on the Role of HIF-1α in Pathogen Infections

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