麻杏石甘口服液治疗肉鸡感染鸡毒支原体的效果评价

doi:10.11843/j.issn.0366-6964.2023.12.035

Abstract

Abstract: The study was conducted to verify the therapeutic effect of Maxing Shigan Oral Liquid on artificial infection of Mycoplasma gallisepticum. Eighty-seven 1-day-old healthy chickens were routinely raised to 20 days of age and randomly divided into infection control group, blank control group and treatment group. The blank control group was fed normally without infection. The chickens in the infection control group and the treatment group were injected with 1.5 mL (10⁹ CCU·mL^-1) of Mycoplasma gallisepticum M17 bacterial solution by nasal drip, eye drop and air sac injection, once a day for 4 days. On the 5th day (D1) of infection, the treatment group was fed with 1.5 mL Maxing Shigan Oral Liquid per liter of water for 5 days, and observed for 6 days after drug withdrawal. The clinical symptoms such as respiration, cough, runny nose, nasal throwing, feeding and mental state of chickens in each group were observed and scored from 1 day (D0) to D11 days before administration. The total score of clinical symptoms, cure rate, effective rate and inefficiency were calculated. The body weight of the chickens was weighed on D0 and D12, and the average weight gain was calculated. On D2, D6 and D12 days, 6 chickens in each group were sacrificed to observe the pathological changes of lung and air sac, and the lungs were collected for histopathological observation. The total score of clinical symptoms in the treatment group decreased significantly on D3 (P<0.05). On D2, D6 and D12, the scores of lung and air sac lesions in the treatment group were significantly lower than those in the infection control group (P<0.05), and the histopathological lesion score of the lung was also significantly lower than that in the infection control group (P<0.05). There was no abnormality in the blank control group. The cure rate of the treatment group was 76.5%, the effective rate was 94.1%, and the ineffective rate was 5.9%. The average weight gain of the infection control group and the treatment group was significantly lower than that of the blank control group (P<0.05). Maxing Shigan oral liquid can significantly improve the pathological damage of air sac and lung tissue of broilers, and has a good therapeutic effect on broilers artificially infected with Mycoplasma gallisepticum.

Key words: Maxing Shigan oral liquid, Mycoplasma gallisepticum, treatment

CLC Number:

S853.9

LEI Yaping, ZHOU Shiwei, TENG Yumeng, NONG Bidan, PANG Xiaomin, ZHANG Yi, LIU Xiaoli, WANG Yulian, HU Xueying. Effect Evaluation of Maxing Shigan Oral Liquid in the Treatment of Broiler Chicken Infected with Mycoplasma gallisepticum[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5264-5274.

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Effect Evaluation of Maxing Shigan Oral Liquid in the Treatment of Broiler Chicken Infected with Mycoplasma gallisepticum

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