纳米抗体及其在兽医领域的研究现状

doi:10.11843/j.issn.0366-6964.2023.08.004

Abstract

Abstract: Nanobody is a kind of single-domain antibody derived from Camelidae and sharks. Compared with the traditional antibody, nanobody has the characteristics of small molecular weight, stable structure, easiness of modification and expression, low immunogenicity, high antigen affinity, strong tissue penetration and so on. Its unique molecular characteristics make it promising for application for diagnosis and treatment of various diseases and assays. This review summarized the structure, characteristics, library types, screening and expression strategies of nanobody and research status in the prevention, diagnosis and treatment of animal disease, as well as the detection of foodborne pathogens and drug residues in animal products. The limitations and future development of nanobody are also analyzed.

Key words: nanobody, characteristics, animal diseases prevention and control, animal products detection

CLC Number:

S852.65

HU Xiangyun, CAO Yanhong, LÜ Lingyan, LIU Zheng, HUANG Facai, WU Zhuyue, XIAO Zhengzhong. Nanobodies and Their Research Status in Veterinary Field[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3164-3172.

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Nanobodies and Their Research Status in Veterinary Field

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