基于网络药理学分析桑叶增强鸡抗氧化功能的作用机制

doi:10.11843/j.issn.0366-6964.2022.06.029

Abstract

Abstract: This study aims to analyze the mechanism of Mori Folium enhancing antioxidative function of chicken. The chemical components and targets of Mori Folium were collected by the traditional Chinese medicine database and analysis platform (TCMSP) and herb database. The compound-target network and the protein-protein interaction (PPI) network of Mori Folium were constructed and analyzed by Cytoscape3.7.2 software, NCBI database and STRING database. In addition, GO enrichment and KEGG pathway of these targets in PPI network were analyzed. The results showed that a total of 30 active compounds were screened, including quercetin, rutin, kaempferol, β-sitosterol, β-carotene and arachidonic acid, which acted on 221 targets. Among them, IL-6, VEGFA, EGF, INS, CAT, CASP3, CCND1, PTGS2, IL-1B and MMP9 were the core targets. GO enrichment and KEGG pathway analysis showed that the role of the targets involved in molecular function, biological process and cell composition, and involved in a number of metabolic pathways such as NOD-like receptor signaling pathway, PPAR signaling pathway, Toll-like receptor signaling pathway and apoptosis. This study theoretically shows that Mori Folium can regulate the antioxidation of chicken based on targets including IL-6, VEGFA, EGF, INS, CAT, CASP3, CCND1, PTGS2, IL-1B and MMP9, which provides enlightenment for further experimental verification and the development of Mori Folium as antioxidation feed additives.

Key words: Mori Folium, chicken, antioxidation, oxidative stress, network pharmacology, target

CLC Number:

R285
S831.5

LIU Weiwei, ZHANG Yuxin, LI Xiumei, WANG Xiumin, ZHOU Weiwei, DAI Xiaofeng. Mechanism of Mori Folium in Improving Antioxidative Function of Chicken Based on Network Pharmacology[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1958-1970.

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Mechanism of Mori Folium in Improving Antioxidative Function of Chicken Based on Network Pharmacology

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