基于网络药理学分析归芪益母汤治疗牛气血两虚证的作用机制

doi:10.11843/j.issn.0366-6964.2018.12.023

Abstract

Abstract:

The aim of our study was to explore the curative effect and compatibility mechanism of Gui Qi Yimu decoction. The chemical constituents and action targets of three kinds of traditional Chinese medicines were studied by pharmacological database and analysis platform of TCMSP. The compound target network, protein interaction PPI network and target pathway network were constructed. Through screening, a total of 24 constituents, 249 targets related to three kinds of traditional Chinese medicines were selected. PPI network contains 182 targets, including TNF, IL8, HSP90AA1, MAPK1, F3, ENSBTAG00000014921, PSMD3, TP53 and other key targets. There are 73 gene Noumenon (GO) entries, including 61 biological process items, 9 molecular functional items and 3 cellular component entries. In addition, there are 11 KEGG pathways, including tumor pathway, T cell receptor signal pathway, Toll like receptor signal pathway, apoptosis, calcium signal pathway, and so on. The results of the study preliminarily verified the basic pharmacological effects and related mechanisms of Guiqi Yimu decoction, which laid a foundation for further study of its action mechanism.

CLC Number:

S853.74

DONG Zhen, BAI Dong-dong, LIU Li-li, BAI Yu-bin, WANG Wei-wei, ZHANG Ji-yu, ZHOU Xu-zheng. The Mechanism of Gui Qi Yimu Decoction Powder in Treating Cow Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2733-2744.

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The Mechanism of Gui Qi Yimu Decoction Powder in Treating Cow Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology

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