双峰驼CYP基因家族的比较研究

doi:10.11843/j.issn.0366-6964.2015.07.010

Abstract

Abstract:

In order to investigate whether the Bactrian camel’s special metabolic pathways and unique detoxic capabilities were caused by particularities of CYP gene family，the Bactrian camel’s whole genome sequencing data were systemically analyzed and annotated，and then CYP gene family was searched from the whole protein database，and compared with CYP gene families of cattle，horse，chicken and human，respectively.The results showed that the total of 63 CYP gene copies were found in Bactrian camel’s whole genome，and were classified into 17 families and 38 subfamilies.Among them，9 multi gene families were found，and CYP2，CYP3 and CYP4 had 27，6 and 7 subfamilies，accounting for 43%，10% and 11% in camel CYP，respectively.Compared with cattle，chicken，horse and human，the distribution of CYP gene subfamilies in camel was different，with more CYP2J and CYP3A copies in Bactrian camel，which was probably associated with Bactrian camel’s some specific biological characteristics and metabolic pathways.Therefore，the certain special biological characteristics and metabolic pathways of Bactrian camels are related to their high copy number of CYP2J and CYP3A genes，and the present analytical results will lay a good foundation for further revealing of Bactrian camel’s unique properties of salt tolerance and detoxification.

CLC Number:

S813.3

HASI Su-rong,LI Qing，YU Siri-guleng，JIRI Mu-tu. Comparative Study of CYP Gene Family in Bactrian Camel（Camelus bactrianus）[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(7): 1150-1156.

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Comparative Study of CYP Gene Family in Bactrian Camel（Camelus bactrianus）

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