基于通路分析方法诠释肉鸡体重性状全基因组关联研究

doi:10.11843/j.issn.0366-6964.2017.05.004

Abstract

Abstract:

To identify the pathways associated with body weight and average daily gain, we conducted the genome-wide association study(GWAS) and SNP ratio test(SRT) of F2 populations derived from a local Chinese breed (Beijing-You chickens) and a commercial fast-growing broiler line (Cobb-Vantress). In this study, the body weight of F2 chickens were measured at 14-day-old, 28-day-old, 56-day-old and 93-day-old, and the average daily gains of each period were calculated, respectively. The GWAS of body weight and average daily gain were carried out. The SRT was performed using the significant SNPs obtained from the GWAS. The results showed that biosynthesis of steroid hormones, metabolism of nicotinic acid and glycolysis/gluconeogenesis were genome-wide significantly associated with 14-day-old, 56-day-old and 93-day-old body weight(P<0.05), respectively. Specially, amino acid metabolic processes were also associated with the body weight(P<0.05) in each period. The enriched pathways by SNPs associated with daily gain were the most abundant in 42-56 days, these pathways were enriched in TCA cycle, steroid biosynthesis, steroid hormone biosynthesis, oxidative phosphorylation, inositol phosphate metabolism and glycerophospholipid metabolism. In brief, biosynthesis of steroid hormones plays an important role in the rapid growth of body weight of broiler, and a large number of amino acid metabolic processes are also associated with average daily gain.

CLC Number:

S813.2

WANG Jie, LIU Lu, LIU Jie, ZHAO Gui-ping, LIU Ran-ran, ZHENG Mai-qing, WEN Jie. Genome-wide Association Study on Body Weight Traits of Broilers Based on Pathway[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(5): 810-817.

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Genome-wide Association Study on Body Weight Traits of Broilers Based on Pathway

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