小型猪专用复合麻醉剂麻醉后阿替美唑的颉颃效果及其体内药代动力学

doi:10.11843/j.issn.0366-6964.2014.12.023

Abstract

Abstract:

This study was conducted to investigate the antagonistic effect of atipamezole and following anaesthesia with the Combined Anaesthetic for Miniature Pigs (XFM) and its pharmacokinetics in minipigs.Fourteen pigs were randomly divided into control group and atipamezole group.All experiment pigs were anesthetised with XFM intramuscularly.Pigs in atipamezole group were administrated with atipamezole (0.12 mg•kg－1) intramuscularly and pigs in control group were administrated with saline.Baseline physiological parameters of respiration and heart rate were recorded and blood sample were collected from cranial vena cava and detected by using high performance liquid chromatography (HPLC) for drug analysis in different phases.Results showed that the recovery time in the atipamezole group was significantly shorter than control group (P<0.05)，values of HR were significantly higher than control group from 5 to 60 min after administration of atipamezole (P<0.05)，values of RR were significantly higher than control group from 10 to 15 min after administration of atipamezole (P<0.05)，the total scores of analgesia，sedation，skelaxin，posture，and auditory response were significantly higher than control group from 10 to 15 min after administration of atipamezole (P<0.05)，and pharmacokinetic parameters were as follows: T_1/2α was 11.0569±3.0934 min，T_1/2β was 875.421 8±159.375 3 min，AUC was 797 958.836 0±96 783.124 1 pg•(min•mL)^－1，T_peak was 9.544 0±0.484 4 min，C_max was 1 107.0652±121.620 1 pg•mL^－1.These results indicated that atipamezole is characterized by rapid drug action，slow metabolism，its best pharmacokinetic model was two-compartment open model，and atipamezole was effective for antagonizing the anaesthesia with XFM in minipigs.

CLC Number:

S859.791

JIANG Sheng，TAN Li-juan，LI Xin，FAN Hong-gang，WANG Hong-bin. Antagonistic Effect of Atipamezole and Its Pharmacokinetics Following Anaesthesia with the Combined Anaesthetic for Miniature Pigs in Minipigs[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(12): 2074-2080.

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Antagonistic Effect of Atipamezole and Its Pharmacokinetics Following Anaesthesia with the Combined Anaesthetic for Miniature Pigs in Minipigs

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