阿法沙龙与异氟烷静吸复合麻醉对犬麻醉效果的影响

doi:10.11843/j.issn.0366-6964.2021.04.027

Abstract

Abstract: In this study, we compared the anesthetic effect of intravenous-inhalation anesthesia(IVIA) of different doses of alfaxalone combined with isoflurane in dogs. Eighteen experimental dogs were randomly numbered and divided into three groups: L (No.1-6), M (No.7-12) and H (No.13-18). Alfaxalone 3, 6, 9 mg·(kg·h)^-1 intravenous constant rate infusion (CRI) combined with 0.5% isoflurane inhalation was used, for maintenance anesthesia, respectively. The physiological indexes, analgesia, sedation and muscle relaxant effect of dogs were observed and recorded at 1 h (T0) before induction anesthesia, 15 min, 30 min, 45 min, and 60 min during maintenance anesthesia, and 15 min (75 min) after the anesthesia. After 45 days, the 18 dogs were grouped according to their original numbers: CⅠ (No.1-6), CⅡ (No.7-12) and CⅢ (No.13-18) for inhalation maintenance anesthesia (2% isoflurane), all data is also recorded. Propofol was used for induction anesthesia in both rounds. There was no statistically significant difference in physiological indexes between group L and group CⅠ(P>0.05)，however, group L had mild pain reaction；Compared with group M, the temperature and blood oxygen of animals in group CⅡ decreased significantly(P>0.05) and pulse, heart rate, respiratory rate and diastolic blood pressure in group CⅡ significantly decreased (P<0.01). There was no pain response in both groups (M and CⅡ group) during anesthesia. Compared with group H, There were statistical differences in pulse and heart rate in group CⅢ (P<0.05), no pain reaction was observed in both groups (H and CⅢ group) during anesthesia. Both intravenous-inhalation anesthesia and simple inhalation anesthesia can get better anesthesia effect, of which alfaxalone dose of 6 mg/(kg·h)^-1 of IVIA can improve the experimental dogs heart rate and pulse, it has little effect on cardiovascular and temperature, at the same time without pain reaction, good depth of anesthesia and wake up fast, compared with the conventional respiratory simple inhalation anesthesia, this anesthetic scheme can improve the overall anesthesia quality of dogs.

Key words: intravenous-inhalation anesthesia, alfaxalone, isoflurane, anesthestic effect of anesthesi, dogs

CLC Number:

S859.791

DAI Chaoying, LIN Qiangfeng, WU Mengyi, HU Chongwei. Influence of Intravenous-inhalation Anesthesia of Alfaxalone Combined with Isoflurane on Anesthetic Effects in Dogs[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(4): 1115-1125.

References 40

[1]	GOODWIN W A, PASLOSKE K, KEATES H L. Alfaxalone for total intravenous anaesthesia in horses[J]. Vet Anaesth Analg, 2019, 46(2):188-199.
[2]	HUNT J R, GOFF M, JENKINS H, et al. Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs[J]. Vet Anaesth Analg, 2019, 46(4):483-487.
[3]	MARÍN P, BELDA E, LAREDO F G, et al. Pharmacokinetics and sedative effects of alfaxalone with or without dexmedetomidine in rabbits[J]. Res Vet Sci, 2020, 129:6-12.
[4]	KRUSE T N, MESSENGER K M, BOWMAN A S, et al. Pharmacokinetics and pharmacodynamics of alfaxalone after a single intramuscular or intravascular injection in mallard ducks (Anas platyrhynchos)[J]. J Vet Pharmacol Ther, 2019, 42(6):713-721.
[5]	HERBERT G L, BOWLT K L, FORD-FENNAH V, et al. Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy:a comparison of premedication with acepromazine or dexmedetomidine[J]. Vet Anesth Analg, 2013, 40(2):124-133.
[6]	DEHUISSER V, BOSMANS T, KITSHOFF A, et al. Cardiovascular effects, induction and recovery characteristics and alfaxalone dose assessment in alfaxalone versus alfaxalone-fentanyl total intravenous anaesthesia in dogs[J]. Vet Anaesth Analg, 2017, 44(6):1276-1286.
[7]	LERVIK A, TOVERUD S F, KRONTVEIT R, et al. A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and ketamine[J]. Acta Vet Scand, 2020, 62(1):14.
[8]	赵修龙, 刘焕奇, 迟良, 等. 犬异氟烷吸入麻醉的模型建立[J]. 中国兽医杂志, 2016, 52(4):89-91.ZHAO X L, LIU H Q, CHI L, et al. Establishment of canine isoflurane inhalation anesthesia model[J]. Chinese Journal of Veterinary Medicine, 2016, 52(4):89-91. (in Chinese)
[9]	AMBROS B, DUKE-NOVAKOVSKI T, PASLOSKE K S. Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-β-cyclodextrin and propofol in dogs[J]. Am J Vet Res, 2008, 69(11):1391-1398.
[10]	秦立鸣. 静吸复合麻醉与全凭静脉麻醉对老年妇科腹腔镜手术的临床价值[J]. 中国现代药物应用, 2018, 12(4):53-54.QIN L M. Clinical value of intravenous-inhalation anesthesia and intravenous anesthesia for senile gynecological laparoscopic surgery[J]. Chinese Journal of Modern Drug Application, 2018, 12(4):53-54. (in Chinese)
[11]	戴海燕. 静吸复合全身麻醉与全凭静脉麻醉在腹腔镜下结直肠癌根治术中的麻醉效果观察[J]. 中国临床医生杂志, 2016, 44(8):76-78.DAI H Y. Observation on the anesthetic effect of intravenous-inhalation anesthesia with intravenous anesthesia in laparoscopic radical resection of colorectal cancer[J]. Chinese Journal for Clinicians, 2016, 44(8):76-78. (in Chinese)
[12]	张金辉. 七氟醚-瑞芬太尼静吸复合麻醉对子宫肌瘤腹腔镜术后认知功能的影响[J]. 中国计划生育学杂志, 2016, 24(12):824-827.ZHANG J H. The impact of sevoflurane-remifentanil inhalation anesthesia on cognitive function postoperative of patients with uterine fibroids by laparoscopic treated[J]. Chinese Journal of Family Planning, 2016, 24(12):824-827. (in Chinese)
[13]	WARNE L N, BETHS T, FOGAL S, et al. The use of alfaxalone and remifentanil total intravenous anesthesia in a dog undergoing a craniectomy for tumor resection[J]. Can Vet J, 2014, 55(11):1083-1088.
[14]	米洁. 犬吸入麻醉的方案选择、术中监护及其处理方法的研究[D]. 长春:吉林大学, 2017:8-15.MI J. The study of the selection of canine inhalation anesthesia program, intraoperative monitoring and its treatment[D]. Changchun:Jilin University, 2017:8-15. (in Chinese)
[15]	MOÏSE N S, FLANDERS W H, PARIAUT R. Beat-to-beat patterning of sinus rhythm reveals non-linear rhythm in the dog compared to the human[J]. Front Physiol, 2020, 10:1548, doi:10. 3389/fphys. 2019. 01548.
[16]	HASKINS S C. General guidelines for judging anesthetic depth[J]. Vet Clin North Am Small Anim Pract, 1992, 22(2):432-434.
[17]	秦绪伟, 李富金, 刘云. 犬眠宝对猫麻醉效果及心肺功能影响的研究[J]. 山东畜牧兽医, 2013, 34(5):9-11.QIN X W, LI F J, LIU Y. Study on the effect of QFM on anesthesia and cardiopulmonary function in cats[J]. Shandong Journal of Animal Science and Veterinary Medicine, 2013, 34(5):9-11. (in Chinese)
[18]	高利, 肖建华, 王洪斌. 犬眠宝与眠乃宁临床麻醉效果的对比实验[J]. 畜牧兽医杂志, 2008, 27(1):18-20.GAO L, XIAO J H, WANG H B. Compare of anestehsia effects between Quanmianbao and Miannaining[J]. Journal of Animal Science and Veterinary Medicine, 2008, 27(1):18-20. (in Chinese).
[19]	程吉英. 丙泊酚诱导复合异氟烷吸入麻醉对犬生理机能的影响[D]. 合肥:安徽农业大学, 2017:28-31.CHENG J Y. Studies on effects of propofol-induced compound Isoflurane-inhalation anesthesia on physiological function of canine[D]. Hefei:Anhui Agricultural University, 2017:28-31. (in Chinese)
[20]	刘庆. 七氟烷不同浓度下静吸复合麻醉对肝切患者术后苏醒质量的影响[D]. 南宁:广西医科大学, 2013:26-30.LIU Q. Effects of recovery from different concentrations of sevoflurane combined with propofol on patients undergoing partial hepatic resection[D]. Nanning:Guangxi Medical University, 2013:26-30. (in Chinese)
[21]	GIULIANO K K, HENDRICKS J. Inadvertent perioperative hypothermia:current nursing knowledge[J]. Aorn J, 2017, 105(5):453-463.
[22]	FREUNDLICH R E, EHRENFELD J M. Perioperative information systems:opportunities to improve delivery of care and clinical outcomes in cardiac and vascular surgery[J]. J Cardiothorac Vasc Anesth, 2018, 32(3):1458-1463.
[23]	昝小刚, 杜增利. 异丙酚复合芬太尼或瑞芬太尼靶控静脉麻醉与静吸复合麻醉的比较[J]. 河南外科学杂志, 2014, 20(3):46-47.ZAN X G, DU Z L. Comparison of target controlled intravenous anesthesia and intravenous-inhalation anesthesia with propofol combined fentanyl or remifentanil[J]. Henan Journal of Surgery, 2014, 20(3):46-47. (in Chinese)
[24]	李鸿志. 两种麻醉方法对患者HR、呼吸系统、循环系统的影响[J]. 中国疗养医学, 2016, 25(2):172-175.LI H Z. Effects of two anesthesia methods on HR, respiratory and circulatory systems of patients[J]. Chinese Journal of Convalescent Medicine, 2016, 25(2):172-175. (in Chinese)
[25]	DEHUISSER V, BOSMANS T, DEVREESE M, et al. Alfaxalone total intravenous anaesthesia in dogs:pharmacokinetics, cardiovascular data and recovery characteristics[J]. Vet Anaesth Analg, 2019, 46(5):605-612.
[26]	PSATHA E, ALIBHAI H I, JIMENEZ-LOZANO A, et al. Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk[J]. Vet Anaesth Analg, 2011, 38(1):24-36.
[27]	AMBROS B, DUKE-NOVAKOVSKI T, PASLOSKE K S. Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-β-cyclodextrin and propofol in dogs[J]. Am J Vet Res, 2008, 69(11):1391-1398.
[28]	包海泉, 董俊斌. 犬异氟烷吸入麻醉后术中监护和并发症处理方法的探讨[J]. 黑龙江畜牧兽医, 2019(12):74-76.BAO H Q, DONG J B. Intraoperative monitoring and management of complications after inhalation of isoflurane in dogs[J]. Heilongjiang Animal Science and Veterinary Medicine, 2019(12):74-76. (in Chinese)
[29]	MUIR W, LERCHE P, WIESE A, et al. Cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in dogs[J]. Vet Anesth Analg, 2008, 35(6):451-462.
[30]	蒋永琴. 舒芬太尼靶控输注全凭静脉麻醉在围手术期的应用效果[J]. 河南医学研究, 2019, 28(13):2405-2407.JIANG Y Q. The application effects of target-controlled infusion of sufentanil in TIVA during the perioperative period[J]. Henan Medical Research, 2019, 28(13):2405-2407. (in Chinese)
[31]	O'HAGAN B J, PASLOSKE K, MCKINNON C, et al. Clinical evaluation of alfaxalone as an anaesthetic induction agent in dogs less than 12 weeks of age[J]. Aust Vet J, 2012, 90(9):346-350.
[32]	RODRÍGUEZ J M, MUÑOZ-RASCÓN P, NAVARRETE-CALVO R, et al. Comparison of the cardiopulmonary parameters after induction of anaesthesia with alphaxalone or etomidate in dogs[J]. Vet Anaesth Analg, 2012, 39(4):357-365.
[33]	BUISMAN M, WAGNER M C, HASIUK M M, et al. Effects of ketamine and alfaxalone on application of a feline pain assessment scale[J]. J Feline Med Surg, 2016, 18(8):643-651.
[34]	MURISON P J, TABOADA F M. Effect of propofol and alfaxalone on pain after ovariohysterectomy in cats[J]. Vet Rec, 2010, 166(11):334-335.
[35]	蒋朝霞, 陈启国. 七氟烷、异氟烷分别联合丙泊酚用于腹部手术麻醉中的体会[J]. 实用临床医药杂志, 2013, 17(14):110-112.JIANG C X, CHEN Q G. Effect of sevoflurane and isoflurane combined with propofol in the anesthesia of abdominal surgery[J]. Journal of Clinical Medicine in Practice, 2013, 17(14):110-112. (in Chinese)
[36]	YOSHIZAWA K, OKUMURA A, NAKASHIMA K, et al. Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice[J]. Synapse, 2017, 71(8):e21978.
[37]	VISSER S A G, SMULDERS C J G M, REIJERS B P R, et al. Mechanism-based pharmacokinetic-pharma-codynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats[J]. J Pharmacol Exp Ther, 2002, 302(3):1158-1167.
[38]	PASLOSKE K, SAUER B, PERKINS N, et al. Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated greyhound dogs after single, intravenous administration of Alfaxan? at a clinical dose[J]. Vet Pharmcol Ther, 2009, 32(5):510-513.
[39]	PASLOSKE K, GAZZARD B, PERKINS N, et al. A multicentre clinical trial evaluating the efficacy and safety of alfaxalone-CD RTU administered to dogs for induction and maintenance of anaesthesia[C]//Proceedings of the 48th Annual British Small Animal Veterinary Congress. Birmingham, UK, 2005:556.
[40]	KEATES H, WHITTEM T. Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog[J]. Res Vet Sci, 2012, 93(2):904-906.

Influence of Intravenous-inhalation Anesthesia of Alfaxalone Combined with Isoflurane on Anesthetic Effects in Dogs

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