中药桔梗对替米考星在肺脏中药物浓度的影响

doi:10.11843/j.issn.0366-6964.2013.06.022

Abstract

Abstract:

Platycodon grandiflorum has "direct medicines ascending" action documented in the ancient Chinese medicinal book. For studying medicinal direct theory of Platycodon grandiflorum, we have added Platycodon grandiflorum on chicken’s drinking water, and then injected tilmicosin in order to investigate the effect of Platycodon grandiflorum on concentration of tilmicosin residues in lung tissues. We have offered drinking water containing different concentrations of Platycodon grandiflorum to experimental chickens for 4 weeks, and then the control group and experimental group were injected tilmicosin. Tilmicosin was extracted from lung tissues and detected by using high performance liquid chromatography (HPLC). The results showed that Platycodon grandiflorum can improve tilmicosin concentration in chicken lung tissue. These results conformed that Platycodon grandiflorum does have "direct medicines ascending" property.

CLC Number:

S853.74

BIAN Tao, WANG Jian-ping, ZHAO Zhu-jun, ZHONG Xiu-hui. Effect of Platycodon grandiflorum on Concentration of Tilmicosin in Lung Tissues[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(6): 980-984.

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References

刘钟杰，许剑琴.中兽医学［M］.北京:中国农业出版社，2002:199.

李晓二.刍议引经药的功效及其临床应用［J］.江西中医药，1994，25(1):48.

孙洁. 也谈引经药［J］. 中医杂志，1999, 40(1) : 60.

邓中甲.方剂学［M］.北京：中国中医药出版社，2003:154.

周玲.桔梗古今功用辨析［J］.湖北中医杂志，2007，29(12):41-42.

方显树. 桔梗配伍应用刍议［J］.辽宁中医杂志，1992（9）：19.

MODRIC S, WEBB A I, DERENDORF H. Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle［J］. J Vet Pharmacol Ther, 1998, 21(6): 444-452.

李存，沈建忠，江海洋，等.猪组织中替米考星残留的高效液相色谱检测方法研究［J］.畜牧兽医学报，2005，36(10):1075-1078.

王雪敏，石玉祥，李存.羊组织中替米考星残留的检测方法研究［J］.中国动物检疫，2008, 25(11）：34-35.

张素梅，杜向党，吴宁鹏，等.牛肉中替米考星残留的高效液相色谱检测方法研究［J］.黑龙江畜牧兽医，2007(7）:82-84.

STOBBA-WILEY C M, CHANG J P, ELSBURY D T, et al. Determination of tilmicosin residues in chicken, cattle, swine and sheep tissues by liquid chromatography ［J］. J AOAC Int, 2000, 83(4): 837-846.

CHAN W, GERHARDT G C, SALISBURY C D. Determination of tylosin and tilmicosin residues in animal tissues by reversed-phase liquid chromatography ［J］. J AOAC Int, 1994, 77(2):331-333.

王雪敏，李存，石玉祥,等.高效液相色谱法测定动物肺脏中替米考星残留量［J］.中国动物检疫，2010，27(3):47-48.

孔令义.表面活性剂［J］.中药化学，2003（3）：397-399.

李英伦.桔梗“引经”对罗红霉素肺药浓度的影响［J］.中兽医医药杂志,2005（5）：3-5.

李英伦.桔梗对左氧氟沙星在健康鸡体内药动学影响的研究［J］. 畜牧兽医学报，2006，37(2)：183-186.

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Effect of Platycodon grandiflorum on Concentration of Tilmicosin in Lung Tissues

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