捻转血矛线虫的耐药性及其干预途径研究进展

doi:10.11843/j.issn.0366-6964.2025.02.005

Abstract

Abstract:

The resistance of Haemonchus contortus to anthelmintics such as ivermectin and albendazole has become increasingly serious, causing major losses to the aquaculture industry in most countries and regions of the world. Currently, research on drug resistance in Haemonchus contortus focuses on epidemiological studies, drug resistance mechanisms and drug resistance interventions, and has made some progress. In this paper, we review the distribution of drug resistance and its influencing factors, the mechanism of drug resistance and reversal of drug resistance based on cell membrane pumps, autophagy level, cellular respiratory chain, parasite substitution, combined deworming with plant extracts and anthelmintics, and breeding of resistant hosts, to provide a new way of thinking for the study of drug resistance in Haemonchus contortus, and to provide reference bases for the scientific control of Haemonchus contortus, the rational use of drugs, and the development of new drugs. It also provides a reference base for scientific control, rational use of drugs and development of new drugs.

Key words: Haemonchus contortus, drug resistance distribution, drug resistance mechanism, reversal of drug resistance

CLC Number:

S852.73

LI Anben, FU Nana, LUO Xiaoping, LI Junyan, LIU Yang. Progress in the Study of Drug Resistance and Its Reversal in Haemonchus contortus[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(2): 523-533.

Figures/Tables 3

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84	GUO Z Y , GONZÁLEZ J F , HERNANDEZ J N , et al. Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands[J]. Sci Rep, 2016, 6 (1): 26200.
85	ANDRONICOS N , HUNT P , WINDON R . Expression of genes in gastrointestinal and lymphatic tissues during parasite infection in sheep genetically resistant or susceptible to Trichostrongylus colubriformis and Haemonchus contortus[J]. Int J Parasitol, 2010, 40 (4): 417- 429.
86	SALLÉG , DEISS V , MARQUIS C , et al. Genetic×environment variation in sheep lines bred for divergent resistance to strongyle infection[J]. Evol Appl, 2021, 14 (11): 2591- 2602.

地区 Area	驱虫药 Anthelmintic drug	来源 Source
内蒙古乌兰浩特市科尔沁右翼前旗	ABZ、IVM	王腾宇等(2021)
内蒙古乌兰察布市察右后旗	IVM、ABZ	赵学亮等(2019)
内蒙古兴安盟科右前旗	ABZ	石雅琴(2021)
内蒙古察哈尔右翼后旗	ABZ	刘晓磊(2019)
内蒙古锡林郭勒盟辖旗西乌珠穆沁旗	ABZ、IVM	其力木格等(2020)、何秀玲等(2020)
内蒙古巴彦淖尔	ABZ	罗晓平(2021)
内蒙古呼盟、和林、萨拉齐地区	ABZ、IVM	敖登高娃(2017)
内蒙古乌审旗	ABZ、IVM	赵学亮(2019)、额叶勒德格等(2018)
黑龙江鹤岗市	ABZ	李莹(2018)
新疆昭君县	IVM	瓦热斯·吐尔松(2022)
新疆博乐市、阿勒泰市、塔城市	ABZ	李泽华(2020)、肖培培等(2020)
新疆乌鲁木齐	IVM、ABZ	赵江山等(2010)
陕西	ABZ、IVM	冯向阳等(2016)
江苏、安徽、河南、吉林、辽宁	ABZ	李泽华(2020)
河北坝上高原地区	ABZ	赵月兰等(2004)
青海民和县、互助县、湟中县、化隆县、湟源县、共和县	ABZ	宁鹏等(2018)
宁夏灵武、贺兰、盐池、吴忠、中卫、水宁	ABZ、IVM	蔡葵蒸(2007)
湖北	ABZ	杨新(2018)
四川	ABZ	罗伏林(2005)
湖南环洞庭湖区地区	ABZ	成钢等(2015)

地区 Area	驱虫药 Anthelmintic drug	来源 Source
丹麦	ABZ、IVM	Holm等(2014)
乌拉圭	ABZ	Munguía等(2018)
肯尼亚	ABZ、IVM	Waruiru等(1997)
印度	ABZ、IVM	Singh等(2021)，Chandra等(2015)
荷兰	ABZ、IVM	Ploeger等(2018)
新西兰	ABZ、IVM	Sutherland等(2008)，Vickers等(2001)
澳大利亚	ABZ、IVM	Lamb等(2017)
莫桑比克	ABZ	Atanásio-Nhacumbe等(2018)
巴西	ABZ、IVM	Ramos等(2016)，Lambert等(2017)
美国南方	ABZ、IVM	Gasbarre等(2009)
瑞士和德国南部	ABZ	Scheuerle等(2009)
加拿大	ABZ	Barrere等(2013)
波兰	ABZ	Mickiewicz等(2021)
圣埃斯皮里图	IVM、ABZ	Viana等(2021)
哥伦比亚	IVM、ABZ	Chaparro等(2017)

科 Family	植物及提取物 Plants & Extracts
豆科Leguminosae	相思豆(Abrus precatorius Linn.)^[63]、长角豆(Ceratonia siliqua Linn)^[64]、青葙(Celosia argentea Linn.)、合欢(Albizia julibrissin Durazz.)^[65]、决明(Cassia tora Linn.)^[66]、凤凰花(Delonix regia (Boj.) Raf.)^[67]、刺桐树皮(Erythrina variegata Linn.)^[68]、平滑牧豆树叶(Prosopis laevigata)：异鼠李素^[69]
菊科Asteraceae	青蒿(Artemisia carvifolia Buch.-Ham. ex Roxb.)^[70]、金毛菊(Thymophylla tenuiloba Small)、万寿菊(Tagetes erecta L.)、蒲公英(Taraxacum mongolicum Hand.-Mazz.)^[71]、白蒿(Leontopodium dedekensii)、欧洲千里光(Senecio vulgaris Linn.)^[72]
蔷薇科Rosaceae	地榆(Sanguisorba officinalis Linn.)、紫色悬钩子(Rubus irritans Focke)^[73]、多毛风车子(Combretum molle R.Br. ex G.Don)^[74]
夹竹桃科Apocynaceae	狗牙花(Ervatamia divaricata (L.) Burk. cv. Gouyahua)^[75]
杨梅科Myricaceae	乌兰杜瓦杨梅(Myrica rubra Siebold et Zuccarini)
楝科Meliaceae	苦楝(Melia azedarace L.)^[76]
芸香科Rutaceae	芸香(Ruta graveolens Linn.)
使君子科Combretaceae	毗黎勒(Terminalia bellirica (Gaertn.) Roxb.)^[77]
卫矛科Celastraceae	塞内加尔美登木(Maytenus hookeri Loes.)^[78]
凤梨Bromeliaceae	凤梨(Ananas comosus (Linn.) Merr.)^[79]
麻黄科Ephedraceae	麻黄(Ephedra sinica Stapf)^[80]
漆树科Anacardiaceae	腰果壳(Anacardium occidentale Linn.)
五味子科Schisandraceae	八角果(Illicium verum Hook. f.)^[81]
报春花科Primulaceae	过路黄(Lysimachia christinae Hance)
松科Pinaceae	雪松(Cedrus deodara (Roxburgh) G. Don)
芭蕉科Musaceae	香蕉(Musa nana Lour.)^[82]
马钱科Loganiaceae	石竹参(Spigelia anthelmia L.)^[83]

[1]	ZHANG Yanmin, ZHAO Dongxu, WANG Wenlong. Mechanism of Resistance to Ivermectin in the Haemonchus contortus [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1511-1520.
[2]	ZHANG Shaohua, WANG Shuai, ZOU Yang, LIU Zhongli, CAI Xuepeng. Advances in Detection Approaches for Ovine Haemonchosis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1499-1510.
[3]	XIE Xinran, ZHANG Yue, LU Mingmin, XU Lixin, SONG Xiaokai, LI Xiangrui, YAN Ruofeng. Effects of Recombinant Phosphatidylinositol Transfer Protein from Haemonchus contortus on the Transcription of Pattern Recognition Receptors and Cytokines in Goat Peripheral Blood Mononuclear Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 252-262.
[4]	LIANG Gaoxing, RONG Shiqi, WANG Junwei, LI Yuan, YANG Xin, ZHAO Guanghui, SONG Junke. Multi-locus Gene Sequence Analysis of Female Haemonchus contortus with Morphological Differences in Vulval Flap from Goat [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 3140-3148.

Progress in the Study of Drug Resistance and Its Reversal in Haemonchus contortus

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