NLRP1炎性小体的激活机制

doi:10.11843/j.issn.0366-6964.2023.02.008

Abstract

Abstract: Nucleotide-binding oligomerization domain-like receptor protein 1 (NLRP1) is a member of the NOD-like receptors (NLRs) family, and is the first NLR family protein found to form inflammasome. The activation of NLRP1 can cause the activation of pro-caspase-1 and further promote the maturation and release of inflammatory factors, which plays an important role in innate immunity. The domain structure of NLRP1 varies among different species. At present, the mechanisms that can cause NLRP1 activation mainly include degradation and activation of NLRP1 through proteasome pathway, activation of NLRP1 through inhibition of DPP9, and activation of NLRP1 by Toxoplasma gondii and some metabolic inhibitors. Some viral proteins or RNAs can also activate NLRP1. How the virus activates NLRP1 and the role of NLRP1 in antiviral infection are not clear, and need to be further studied.

Key words: NLRP1, inflammasome, virus, activation mechanism

CLC Number:

S852.4

HE Haojie, XUE Mei, FENG Li. Activation Mechanism of NLRP1 Inflammasome[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 494-503.

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Activation Mechanism of NLRP1 Inflammasome

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