纳米技术改良黄酮类化合物在动物健康养殖中的应用潜力

doi:10.11843/j.issn.0366-6964.2025.07.007

Abstract

Abstract:

Flavonoids are compounds characterized by a C6-C3-C6 basic skeleton, consisting of two benzene rings connected by three carbon atoms. They can be categorized into various subclasses, such as flavonoids and anthocyanins. These compounds exhibit numerous biological effects, including antibacterial, anti-inflammatory, antioxidant, and immune-boosting activities. However, flavonoids face challenges such as low solubility, poor stability, limited permeability, and low bioavailability due to their chemical composition. With the advancement and maturation of nanotechnology, nanoparticles derived from natural macromolecular substances have significantly improved the solubility and biological functions of flavonoids. This paper integrates and summarizes the research on flavonoid nanoparticles, elucidating their mechanisms of action and providing a theoretical basis for their development and application in animal production.

Key words: flavonoids, nanotechnology, bacteriostasis, anti-inflammatory, antioxidant

CLC Number:

S816.7

ZHANG Chenmiao, CHEN Bowen, JIANG Linshu, TONG Jinjin. Potential Applications of Nanotechnology-Improved Flavonoids in Animal Health Management[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(7): 3107-3115.

Figures/Tables 1

Table 1

Characterization and application effect comparison of loaded flavonoid nanoparticles"

品种 Item	纳米颗粒 NPs	黄酮类 Flavonoid	粒径/nm Size	形状 Shape	Zeta电位/mV Zeta potential	应用效果 Application effect	文献 Reference
聚合物纳米颗粒 Polymer nanoparticles	钴基纳米聚合物	姜黄素	150	菱形12面体	—	姜黄素抗氧化功效显著提高	[19]
	甲氧基聚己二醇聚己内酯	姜黄素	111.16±3.26	—	5.67±5.26	纳米颗粒的姜黄素聚合物使微生物数量明显下降	[20]
	聚乳酸-羟基乙酸共聚物	橙皮苷	—	—	—	抗氧化和抗菌方面发挥作用	[21]
多糖纳米颗粒 Polysaccharide nanoparticles	壳聚糖	槲皮素	327.9	—	>30	有效改善感染组织周围的炎性症状	[22]
	壳聚糖	姜黄素	160±10	—	7±2	增强对葡萄球菌、大肠杆菌、枯草芽孢杆菌的生长抑制	[24]
	果胶	柑桔皮提取物	271.5±5.3	球形	—	释放特性得到加强，氧化活性得到提升	[26]
	果胶	茶树花黄酮	238±4.55	球形或椭球形	-27.38	更好的自由基清除率与储藏稳定性	[27]
	藜麦淀粉	芦丁	107	球形	-18.0	有效控制了芦丁的释放率，提高体外的生物利用率和抗氧化活性	[29]
	玉米淀粉	芦丁	222	球形	-18.6	有效控制了芦丁的释放率，提高体外的生物利用率和抗氧化活性	[29]
	淀粉	姜黄素	104.6~406.7	米粒状	—	姜黄素的热稳定性、pH稳定性、光稳定性显著提高	[30]
脂质纳米颗粒 Lipid nanoparticles	磷脂、胆固醇和吐温80	姜黄素	68.1	—	-3.16	显著提高姜黄素的抗氧化性和细胞渗透性	[31]
脂质纳米颗粒 Lipid nanoparticles	脂质	姜黄素	38.9	球形	-6.86	可使难溶性药物释放量明显增加，粒径小、包封率高、载药量大	[35]
蛋白质纳米颗粒 Protein nanoparticles	酪蛋白	槲皮素	200	球形	-15	与口服溶液中的檞皮素含量相比，口服相对生物利用程度高出9倍	[36]
蛋白质纳米颗粒 Protein nanoparticles	玉米醇溶蛋	二氢杨梅素	206.4	球形	-29.6	稳定性显著提高	[38]
金属纳米颗粒 Metal nanoparticles	银	芦丁	4~17	球形	0.241	大肠杆菌和金黄色葡萄球菌在经过30次洗涤后，抗菌活性仍然超过90%	[42]
金属纳米颗粒 Metal nanoparticles	银	二氢杨梅素	114.76±1.34	多分散混合物	-16.5±2.1	自由基清除率在56%~92%左右，具有更强的抗氧化性	[43]
复合纳米颗粒 Composite nanoparticles	玉米醇溶蛋白-可溶性大豆多糖	槲皮素	200	—	—	相较于单一玉米醇溶蛋白包封率增加了23.3%	[44]
复合纳米颗粒 Composite nanoparticles	玉米醇溶蛋白-硫酸葡聚糖复合物	姜黄素	123	—	—	稳定性显著提高	[45]

Table 1

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Potential Applications of Nanotechnology-Improved Flavonoids in Animal Health Management

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