新型生物组织工程角膜移植治疗犬猫角膜疾病的回顾性分析

doi:10.11843/j.issn.0366-6964.2023.10.035

Abstract

Abstract: This study was conducted to retrospectively analyze and summarize the surgical methods and long-term clinical effects of the new biotissue-engineered cornea (BEC) in the treatment of corneal diseases in canine and feline. This study reviewed the medical records of canine and feline useing BEC for ocular surface transplantation from 2018 to 2022 and followed up for at least 3 months. The eyes of animals including sequestrum, deep corneal ulcer, descemetocele and corneal perforation were included in the study. The patients were examined regularly every week after surgery, and selected eyes were examined with optical coherence tomography at 0, 3, 6 and 12 months after surgery. The corneas of the patients were graded according to the results of the last examination. A total of 139 eyes (112 of feline and 27 of canine) were included in this study, including 103 eyes with lamellar keratoplasty and 36 eyes with full-thickness keratoplasty. Four different thicknesses of BEC implants (200, 300, 400 and 450 μm) were used. The average diameter of the graft was 7.74 mm (range:3-13 mm). Postoperative complications with relatively impact included partial graft loosening or dehiscence (5 cases, 3.60%), graft dissolution or perforation (8 cases, 5.76%), corneal graft bed sequestrum (1 case, 0.72%) and atrophia bulbi (1 case, 0.72%). The follow-up time spanned 3-50 months (median 18 months). Finally, 139 eyes maintained the integrity of cornea and eyeball, and 133 eyes (95.68%) retained relatively sharp vision. Statistical analysis showed that corneal graft transparency was significantly and positively correlated with animal age (P=0.021), species (P=0.000), Graft diameter (P=0.032), full thickness transplantation or not (P=0.000), and corneal re-epithelialization time (P=0.000). BEC is a safe and effective corneal graft, which can be used for lamellar or full-thickness keratoplasty in canine and feline, and has extensive clinical application value.

Key words: canine, feline, corneal transplant, biotissue-engineered cornea

CLC Number:

S857.6

XU Huihao, JIAO Yien, ZHENG Xiaobo, ZHANG Zhipeng, YANG Lihui, LIN Jinzhou, WANG Libo, TANG Jing, LI Qijuan, LIU Jiangyu, CHEN Ziyang, HU Xiaoyan, PIAO Xueling, ZHANG Hui, GAN Ling. A Large Retrospective Study on the Treatment of Corneal Diseases in Dogs and Cats with a New Type of Bioengineered Cornea Transplantation[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4389-4402.

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A Large Retrospective Study on the Treatment of Corneal Diseases in Dogs and Cats with a New Type of Bioengineered Cornea Transplantation

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