Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (2): 463-472.doi: 10.11843/j.issn.0366-6964.2023.02.005

• REVIEW • Previous Articles     Next Articles

MicroRNAs Regulate Antiviral Immunity and Viral Replication

WANG Lan1,2, HE Mingyu1,2, ZHANG Min1,2, DING Juntao1,2*   

  1. 1. College of Life Science and Technology, Xinjiang University, Urumqi 830046, China;
    2. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Urumqi 830046, China
  • Received:2022-02-22 Online:2023-02-23 Published:2023-02-21

Abstract: MicroRNA(miRNA) is a class of highly conserved endogenous non-coding single-stranded small RNA molecules, about 19~25 nt in length, which usually plays a regulatory role in the post-transcriptional level of gene expression and participates in a variety of life activities such as cell development, proliferation, apoptosis and immunity. A large number of studies have shown that a variety of miRNAs regulate viral replication, cell proliferation or apoptosis and tumor development during viral infection through direct or indirect methods. This paper mainly reviews the regulatory mechanism of miRNA in immune response and viral replication during viral infection, aiming to provide reference for the development and application of miRNA and antiviral related treatment strategies.

Key words: microRNA, viral infection, viral replication, immune regulation

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