Abstract: The purpose of this experiment was to study the anti-allergic effect of hypoallergenic pet core material and preliminarily explore its possible mechanism. Five weeks old female BALB/c mice were used in the experimental. Ovalbumin (OVA) was administered to establish a food-borne allergy mouse model. Meanwhile, hypoallergenic pet core material was given to investigate the effect of this core material on the intestinal structure and allergic reaction of food-borne allergic mice. The anti-allergic mechanism was explored through the detection of immunoglobulin, cytokines, histamine, and immune organ index in mice. Compared with the control group, the average daily gain of food-induced allergic mice was significantly decreased (P<0.01); the villus height, crypt depth, and the ratio of which were significantly decreased (P<0.05 or P<0.01); diarrhea rate was up to 86% which was highly significantly increased (P<0.01), the rectal temperature was significantly decreased (P<0.01), and the allergic reaction score was significantly increased (P<0.01); the serum levels of IgE, IgG, His, and IL-4 were extremely significantly increased (P<0.01), the IL-10 levels were significantly decreased (P<0.01), and the number of degranulated mast cells was significantly increased (P<0.05); thymus and spleen index were significantly decreased (P<0.01); the above indexes of mice given hypoallergenic pet core material were significantly improved compared with the model mice. The hypoallergenic pet core material can inhibit the degranulation of mast cells, reduce the release of histamine, inhibit the occurrence of food induced allergic reaction in mice induced by OVA, reduce the symptoms of allergic reaction, increase the height of villi, improve the intestinal tissue structure of allergic mice and the absorption of nutrients of mice.

Key words: allergy, inflammatory factors, mast cells, ovalbumin, mice