新城疫病毒M蛋白细胞核定位的机制与功能研究进展

doi:10.11843/j.issn.0366-6964.2021.04.005

Abstract

Abstract: The M protein of Newcastle disease virus (NDV) is a non-glycosylated membrane-associated protein, which locates at the inner surface of NDV envelope and constitutes the bridge between the viral envelope and the nucleocapsid. Studies have demonstrated that the M protein is a nucleocytoplasmic shuttling protein, and can localize in the nucleus via its intrinsic nuclear localization signal early in NDV infection. According to the reported functions of RNA viruses M protein, the early nuclear localization of NDV M protein may benefit for viral genome replication and transcription, and also inhibit cell gene transcription and protein synthesis. At present, numerous studies have focused on the relationship between M protein and NDV virulence and replication, and also the formation mechanism and utilization of M protein-based virus-like particles. However, there have little researches about the mechanism and function of M’s nuclear localization. Due to the crucial roles of M protein in the replication and pathogenicity of NDV, this summary mainly reviews the cellular localization characteristics of M protein and the molecular mechanism and function of M protein in the nucleus, which will provide theoretical references for further studying the nuclear localization functions and mechanisms of NDV M protein.

Key words: Newcastle disease virus, M protein, nuclear localization, nuclear localization signal, gene transcription

CLC Number:

DUAN Zhiqiang, XIE Lingling, ZHOU Di, WANG Yanbi, ZHAO Caiqin, TANG Hong. Research Progress on the Mechanism and Function of Nuclear Localization of Newcastle Disease Virus M Protein[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(4): 891-898.

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Research Progress on the Mechanism and Function of Nuclear Localization of Newcastle Disease Virus M Protein

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