噬菌体的跨黏膜转位以及噬菌体对机体免疫影响的研究进展

doi:10.11843/j.issn.0366-6964.2021.03.003

Abstract

Abstract: The microbial communities of humans and animals are mainly distributed in mucosal organs. Recent studies have shown that bacteriophages can adhere to mucosal surfaces and provide an antimicrobial defense. In the meantime, bacteriophages translocate across the mucosa into the body and migrate with the blood to other tissues and organs, giving rise to the body's immune response and affecting systemic immunity. However, these endogenous bacteriophages can be eliminated through phagocytosis or specific antibodies. At present, there is still a lack of research on phage translocation and interaction with the immune system after entering the body. Here we review recent researches on bacteriophages adhering to the mucosa and translocating into the circulatory system, as well as the effect of endogenous bacteriophages on systemic immunity. This review may provide a reference for more extensive and in-depth studies in the future.

Key words: bacteriophage, bacteriophage translocation, inflammatory response, phagocytosis, neutralizing antibodies

CLC Number:

Q939.48

LIU Yankun, LIN Yan, ZHU Weiyun. Advances in the Bacteriophage Translocation and the Effect of Bacteriophage on the Immunity[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(3): 588-595.

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Advances in the Bacteriophage Translocation and the Effect of Bacteriophage on the Immunity

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