鸽乳的组成及其生成调控机制的研究进展

doi:10.11843/j.issn.0366-6964.2020.09.002

Abstract

Abstract: Pigeon milk (PM) is a semi-solid nutrient substance produced and secreted by the crop of pigeon and it is the only nutritional source of squab. Squabs should be fed by their parents because they could not eat by themselves, so PM is very important for their growth and development. The production and secretion of PM is a special physiological process, which is rare in birds and different from the lactation process of mammals. PM is mainly composed of proteins, lipids, carbohydrates and minerals. Synthesis and secretion of PM are regulated by numerous hormones such as prolactin, insulin and relaxin. The signaling pathways such as JAK/STAT, PI3K/Akt/TOR, AMPK and Wnt are activated by these hormones and then the expression of related genes are regulated. The processes of crop epithelial cell proliferation, degeneration, nutrient synthesis and enrichment are regulated. The composition of pigeon milk and its production regulatory mechanism are reviewed, we compare these characteristics of PM with mammalian milk, and the physiological mechanism of pigeon milk production by crop and its similarities and differences with mammalian mammary lactation are further clarified. Research on the composition of PM will provide reference for the formulating of breeding pigeon nutrition requirements and research of artificial PM. The regulation mechanism of PM production will further find out genes regulating lactation and select breeding populations with high yield of PM by using molecular marker-assisted breeding technology.

Key words: pigeon, pigeon milk, crop, hormone, regulatory mechanism

CLC Number:

S852.2

BIAN Shixiong, SUN Yanyan, MA Hui, CHEN Jilan. Research Progress on the Composition and Production Regulatory Mechanism of Pigeon Milk[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(9): 2048-2058.

References 63

[1]	张晓昀.碱性氨基酸对乳鸽早期生长发育调控的研究[D].杭州:浙江大学,2018.ZHANG X Y.Research on early development regulation of pigeon squabs by cationic amino acids[D].Hangzhou:Zhejiang University, 2018.(in Chinese)
[2]	SHAPIRO M D,DOMYAN E T.Domestic pigeons[J].Curr Biol,2013,23(8):R302-R303.
[3]	GILLESPIE M J,HARING V R,MCCOLL K A,et al.Histological and global gene expression analysis of the ‘lactating’ pigeon crop[J].BMC Genomics,2011,12(1):452.
[4]	RENDÓN M A,GARRIDO A,RENDÓN-MARTOS M,et al.Assessing sex-related chick provisioning in greater flamingo Phoenicopterus roseus parents using capture-recapture models[J].J Anim Ecol,2014,83(2):479-490.
[5]	FRETWELL P T,TRATHAN P N,WIENECKE B,et al.Emperor penguins breeding on iceshelves[J].PLoS One,2014,9(1):e85285.
[6]	GILLESPIE M J,CROWLEY T M,HARING V R,et al.Erratum to:transcriptome analysis of pigeon milk production-role of cornification and triglyceride synthesis genes[J].BMC Genomics,2014,15(1):185.
[7]	LUO Y,WANG X,MA Y,et al.The biological function of pigeon crop milk and the regulation of its production[J]. Hereditas, 2017,39(12):1158-1167.
[8]	谢鹏,万雪萍,卜柱,等.鸽乳分泌特征及鸽营养需求研究进展[J].中国家禽,2018,40(11):47-51.XIE P,WAN X P,BU Z,et al.Formation of crop milk and nutrition requirement of the domestic pigeon (Columba livia domestica):a review[J].China Poultry,2018,40(11):47-51.(in Chinese)
[9]	张文飞,张红菊,管武太,等.饲粮中添加中链脂肪酸甘油三酯对母猪繁殖性能、血清生化指标及初乳成分的影响[J].动物营养学报,2016,28(10):3256-3263.ZHANG W F,ZHANG H J,GUAN W T,et al.Effects of dietary supplementation of medium-chain triglyceride on reproductive performance,serum biochemical indices and colostrum composition of sows[J].Chinese Journal of Animal Nutrition,2016, 28(10):3256-3263.(in Chinese)
[10]	吴富鑫,童津津,张华,等.不同泌乳量奶牛行为学差异及其与泌乳性能的相关性[J].动物营养学报,2019,31(7):3156-3163.WU F X,TONG J J,ZHANG H,et al. Behavioral differences of different milk yield dairy cows and its correlation with lactation performance[J].Chinese Journal of Animal Nutrition,2019,31(7):3156-3163.(in Chinese)
[11]	薛建龙.牛羊乳中蛋白质和脂肪的差异比较研究[D].西安:陕西科技大学, 2015.XUE J L.Compatative study on differences of fat and protein in goat and bovine milk[D].Xi'an:Shaanxi University of Science & Technology,2015.(in Chinese)
[12]	吴立芳.母乳重要成分研究及其结果与婴幼儿配方粉对比研究[D].北京:中国疾病预防控制中心,2015.WU L F.Human milk composition study and the comparative study on key components in breast milk and infant formula[D]. Beijing:Chinese Center for Disease Control and Prevention,2015.(in Chinese)
[13]	JACQUIN L,BLOTTIÈRE L,HAUSSY C,et al.Prenatal and postnatal parental effects on immunity and growth in ‘lactating’ pigeons[J].Funct Ecol,2012,26(4):866-875.
[14]	梁勇,姜庆林,陈益填,等.鸽乳成分及其分泌机制研究进展[J].中国家禽,2016,38(20):47-51.LIANG Y,JIANG Q L,CHEN Y T,et al.Pigeon milk composition and research on its secretion mechanism[J].China Poultry, 2016, 38(20):47-51.(in Chinese)
[15]	童津津.泌乳相关激素对奶牛泌乳性能的影响及调控机制研究[D].哈尔滨:东北农业大学,2017.TONG J J.Effect of lactation hormones on the lactational performance and the mechanism in dairy cows[D].Harbin:Northeast Agricultural University,2017.(in Chinese)
[16]	GILLESPIE M J,STANLEY D,CHEN H,et al.Functional similarities between pigeon ‘milk’ and mammalian milk:induction of immune gene expression and modification of the microbiota[J].PLoS One,2012,7(10):e48363.
[17]	张花,李大彪,邢媛媛,等.脂肪酸对奶牛乳腺上皮细胞乳蛋白和乳脂合成相关基因表达量的影响[J].动物营养学报,2017,29(11):4143-4150.ZHANG H,LI D B,XING Y Y,et al.Effects of fatty acids on expression levels of genes involved in milk protein and milk fat synthesis in bovine mammary epithelial cells[J].Chinese Journal of Animal Nutrition,2017,29(11):4143-4150.(in Chinese)
[18]	DUMONT J N.Prolactin-induced cytologic changes in the mucosa of the pigeon crop during crop-"milk" formation[J].Z Zellforsch Mikrosk Anat,1965,68(6):755-782.
[19]	林余秋,韩联众,陈东良.种鸽繁殖周期与生产效率[J].养禽与禽病防治,2004(5):32-34.LIN Y Q,HAN L Z,CHEN D L.Breeding cycle and production efficiency of breeding pigeon[J].Poultry Husbandry and Disease Control,2004(5):32-34.(in Chinese)
[20]	陈莲官,吴高升,葛姣珍.不同繁殖时期肉鸽嗉囊变化规律的组织学观察[J].浙江农业大学学报,1993,19(4):459-462.CHEN L G,WU G S,GE J Z.Histological observation on the crop variation of meat pigeon in different reproductive cycle[J].Journal of Zhejiang Agricultural University,1993,19(4):459-462.(in Chinese)
[21]	胡小超.不同繁殖周期种鸽嗉囊生理结构及鸽乳蛋白质合成的机制[D].广州:华南农业大学,2016.HU X C.Crop Physiological Structure at different reproductive cyclesand the mechanism of milk protein synthesis of domestic pigeon (Columba livia)[D].Guangzhou:South China Agricultural University,2016.(in Chinese)
[22]	WAN X P,XIE P,BU Z,et al.Prolactin induces lipid synthesis of organ-cultured pigeon crops[J].Poult Sci, 2019,98(4):1842-1853.
[23]	SALES J,JANSSENS G P J.Nutrition of the domestic pigeon (Columba livia domestica)[J].World's Poult SciJ,2003,59(2):221-232.
[24]	单达聪,王铮,黄建国,等.乳鸽早期生长及鸽乳营养水平的研究进展[J].动物营养学报,2019,31(3):981-986.SHAN D C,WANG Z,HUANG J G,et al.Early growth of pigeon squabs and nutrient levels of crop milk[J].Chinese Journal of Animal Nutrition,2019,31(3):981-986.(in Chinese)
[25]	XIE P,WAN X P,BU Z,et al.Changes in hormone profiles,growth factors,and mRNA expression of the related receptors in crop tissue,relative organ weight,and serum biochemical parameters in the domestic pigeon (Columba livia) during incubation and chick-rearing periods under artificial farming conditions[J].Poult Sci,2018,97(6):2189-2202.
[26]	XIE P,WAN X P,BU Z,et al.Differential expression of fatty acid transporters and fatty acid synthesis-related genes in crop tissues of male and female pigeons (Columba livia domestica) during incubation and chick rearing[J].Br Poult Sci,2017, 58(5):594-602.
[27]	BANI G,SACCHI T B,BIGAZZI M.Response of the pigeon crop sac to mammotrophic hormones:comparison between relaxin and prolactin[J].Gen Comp Endocrinol,1990,80(1):16-23.
[28]	PUKAC L A,HORSEMAN N D.Regulation of cloned prolactin-inducible genes in pigeon crop[J].Mol Endocrinol,1987, 1(2):188-194.
[29]	生冉,闫素梅.催乳素与其他激素对乳腺内乳成分合成的协同调节作用[J].动物营养学报,2014,26(6):1435-1443.SHENG R,YAN S M.Prolactin and other hormones:synergistic action on regulating milk composition synthesis in mammary glands[J].Chinese Journal of Animal Nutrition,2014,26(6):1435-1443.(in Chinese)
[30]	MIYOSHI K,SHILLINGFORD J M,SMITH G H,et al.Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium[J].J Cell Biol,2001,155(4):531-542.
[31]	HENNIGHAUSEN L,ROBINSON G W.Signaling pathways in mammary gland development[J].Dev Cell,2001,1(4):467-475.
[32]	AKERS R M.Major advances associated with hormone and growth factor regulation of mammary growth and lactation in dairy cows[J].J Dairy Sci,2006,89(4):1222-1234.
[33]	FERBEYRE G,MORIGGL R.The role of Stat5 transcription factors as tumor suppressors or oncogenes[J].Biochim Biophys Acta Rev Cancer,2011,1815(1):104-114.
[34]	LEAVENS K F,EASTON R M,SHULMAN G I,et al.Akt2 is required for hepatic lipid accumulation in models of insulin resistance[J].Cell Metab,2009,10(5):405-418.
[35]	GORDON B S,WILLIAMSON D L,LANG C H,et al.Nutrient-Induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1[J].J Nutr,2015,145(4):708-713.
[36]	RASHID M,KARIM S,ALI B,et al.PI3K signaling pathway targeting by using different molecular approaches to treat cancer[J].J Chin Pharm Sci,2017,26(9):621-634.
[37]	CHEN M J,FU Z,JIANG S G,et al.Targeted disruption of TORC1 retards young squab growth by inhibiting the synthesis of crop milk protein in breeding pigeon (Columba livia)[J].Poult Sci,2020,99(1):416-422.
[38]	XIE W Y,FU Z,PAN N X,et al.Leucine promotes the growth of squabs by increasing crop milk protein synthesis through the TOR signaling pathway in the domestic pigeon (Columba livia)[J].Poult Sci,2019, 98(11):5514-5524.
[39]	王皓宇,秦彤,郝海生,等.胰岛素对体外培养奶牛乳腺上皮细胞乳蛋白、乳脂肪合成相关基因mRNA表达的影响[J].畜牧兽医学报,2013,44(5):710-718.WANG H Y,QIN T,HAO H S,et al.Effects of insulin on mRNA expression of genes related to milk protein and fat synthesis in bovine mammary epithelial cells cultured in vitro[J].Acta Veterinaria et Zootechnica Sinica,2013,44(5):710-718.(in Chinese)
[40]	SCHWARZ-ROMOND T.Three decades of Wnt signalling[J].EMBO J,2012,31(12):2664.
[41]	张宗明,金成龙,严会超,等.Wnt信号调控骨骼肌生长、发育与再生的机制[J].动物营养学报, 2019, 31(2):560-566.ZHANG Z M,JIN C L,YAN H C,et al.Regulatory mechanism of Wnt signaling in skeletal muscle growth,development and regeneration[J].Chinese Journal of Animal Nutrition,2019,31(2):560-566.(in Chinese)
[42]	张世蘋,张旭.Wnt信号通路在肿瘤调控方面的研究进展[J].中国药理学通报,2017,33(1):14-17,18.ZHANG S P,ZHANG X.Research progress on role of Wnt signaling pathway in regulation of tumors[J].Chinese Pharmacological Bulletin,2017,33(1):14-17,18.(in Chinese)
[43]	CHEN L F,WAN Y C,LIU Y T,et al.Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β-catenin and Akt/mTOR[J].Clin Exp Pharmacol Physiol,2020,47(1):127-134.
[44]	MA H,NI A X,GE P Z,et al.Analysis of Long Non-Coding RNAs and mRNAs associated with lactation in the crop of pigeons (Columba livia)[J].Genes (Basel),2020,11(2):201.
[45]	KOUFARIOTIS L T,CHEN Y P P,CHAMBERLAIN A,et al.A catalogue of novel bovine long noncoding RNA across 18 tissues[J].PLoS One,2015,10(10):e0141225.
[46]	YANG B,JIAO B L,GE W,et al.Transcriptome sequencing to detect the potential role of long non-coding RNAs in bovine mammary gland during the dry and lactation period[J].BMC Genomics,2018,19(1):605.
[47]	吴瑜.印记基因P57在小鼠乳腺发育和泌乳中的功能及其机制初步研究[D].兰州:兰州大学,2016.WU Y.The functions and regulatory mechanism of P57 in mouse mammary development and milk secretion[D].Lanzhou:Lanzhou University,2016.(in Chinese)
[48]	PUKAC L A,HORSEMAN N D.Regulation of pigeon crop gene expression by prolactin[J].Endocrinology, 1984,114(5):1718-1724.
[49]	HORSEMAN N D.A Prolactin-Inducible gene product which is a member of the Calpactin/Lipocortin family[J].Mol Endocrinol, 1989,3(5):773-779.
[50]	LEMAY D G,LYNN D J,MARTIN W F,et al.The bovine lactation genome:insights into the evolution of mammalian milk[J].Genome Biol,2009,10(4):R43.
[51]	MENZIES K K,LEFÈVRE C,SHARP J A,et al.A novel approach identified the FOLR1 gene,a putative regulator of milk protein synthesis[J].Mamm Genome,2009,20(8):498-503.
[52]	王卓然.Pten基因对奶牛乳腺上皮细胞泌乳的调节功能[D].哈尔滨:东北农业大学,2014.WANG Z R.Pten regulates lactation in dairy cow mammary epithelial cells[D].Harbin:Northeast Agricultural University,2014.(in Chinese)
[53]	CHEN M X,LI X G,YANG J X,et al.Growth of embryo and gene expression of nutrient transporters in the small intestine of the domestic pigeon (Columba livia)[J].J Zhejiang Univ Sci B,2015,16(6):511-523.
[54]	SHAPIRO M D,KRONENBERG Z,LI C,et al.Genomic diversity and evolution of the head crest in the rock pigeon[J].Science, 2013,339(6123):1063-1067.
[55]	HU X C,GAO C Q,WANG X H,et al.Crop milk protein is synthesised following activation of the IRS1/Akt/TOR signalling pathway in the domestic pigeon (Columba livia)[J].Br Poult Sci,2016,57(6):855-862.
[56]	HE P P,JIANG T,OUYANG X P,et al.Lipoprotein lipase:biosynthesis,regulatory factors,and its role in atherosclerosis and other diseases[J].Clin Chim Acta,2018,480:126-137.
[57]	董丽艳,卢立志,李国勤,等.白羽王鸽LPL基因的多态性与肉质性状相关性研究[J].中国畜牧杂志, 2016,52(1):17-21.DONG L Y,LU L Z,LI G Q,et al.Correlation between polymorphism of LPL gene and meat quality traits of white feather king pigeon[J].Chinese Journal of Animal Science,2016,52(1):17-21.(in Chinese)
[58]	MA Y,FENG S Y,WANG X,et al.Exploration of exosomal microRNA expression profiles in pigeon ‘Milk’ during the lactation period[J].BMC Genomics,2018,19(1):828.
[59]	FRIEDRICHSEN B N,RICHTER H E,HANSEN J A,et al.Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic β-cells[J].Mol Endocrinol, 2003, 17(5):945-958.
[60]	司雨.SND1基因对奶牛乳腺上皮细胞泌乳机能的影响[D].哈尔滨:东北农业大学,2014.SI Y.The effect of SND1 gene on lactation function of dairy cow mammary epithelial cells[D].Harbin:Northeast Agricultural University,2014.(in Chinese)
[61]	于翠平,高学军,骆超超,等.奶牛泌乳关键基因与乳品质关系[J].乳业科学与技术,2013,36(6):30-33.YU C P,GAO X J,LUO C C,et al.Relationship between key genes for milk secretion and milk quality[J].Journal of Dairy Science and Technology,2013,36(6):30-33.(in Chinese)
[62]	吕艳涛.母猪乳脂合成关键基因筛选及长链脂肪酸对乳脂合成的调控研究[D].广州:华南农业大学, 2016.LV Y T.Genetic screen for controlling milk fat synthesis in lactating sows and studies on the effects of long-chain fatty acids on milk fat synthesis in porcine mammary epithelial cells[D].Guangzhou:South China Agricultural University,2016.(in Chinese)
[63]	KOWALSKA M A,RAUOVA L,PONCZ M.Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis[J].Thromb Res,2010,125(4):292-296.

Research Progress on the Composition and Production Regulatory Mechanism of Pigeon Milk

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 63

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	CHEN Songbiao, LIU Feifei, SHANG Ke, YU Zuhua, HE Lei, WEI Ying, CHEN Jian, ZHANG Chunjie, CHENG Xiangchao, DING Ke. Molecular Mechanism of the “Battle” between Virus Infection and Host Antiviral Immunity-Apoptosis, Necroptosis and Pyroptosis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 59-70.
[2]	WANG Xinxin, LIN Shumei, ZHAO Dongdong, WANG Xuesheng. Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 71-78.
[3]	HE Mingyang, MA Yujing, WANG Yong, YANG Ruochen, LIU Yueqin, ZHANG Yingjie, DUAN Chunhui. Effects of Melatonin on Proliferation, Apoptosis of Ovarian Granulosa Cells, and Its Secretion of Steroid Hormones of Sheep [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3313-3324.
[4]	AN Qi, YU Jialin, WU Xiaoling, DENG Guangcun. Regulation of BCG-induced Apoptosis in Murine Macrophages by Glutamine [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 3054-3063.
[5]	AN Zongqi, ZHAN Siyuan, LI Li, ZHANG Hongping. ceRNA-mediated Function of CircRNA on Critical Economic Traits in Animals [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2215-2222.
[6]	XING Baorui, LIU Zhen, ZHAO Haiping, MA Zefang, LI Xunsheng, ZHOU Jue, SUN Hongmei. Research Progress in Reverse Osteogenesis of Deer Antler [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2231-2240.
[7]	WANG Chongnian, YU Jialin, GONG Zhaoqian, WU Xiaoling, DENG Guangcun. Regulation of BCG-induced Autophagy in Macrophages RAW264.7 by PLIN2 [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2134-2146.
[8]	LI Yu, DUAN Chunhui, SONG Zhipan, YUE Sicong, WANG Yuan, ZHANG Yingjie, LIU Yueqin. Effects of PGF2α on Luteal Tissue Morphology, Expression of PGF2α Receptors and Necroptosis-associated Genes During Luteal Phase in Hu Sheep [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1500-1510.
[9]	WANG Mingli, WANG Meng, LI Yansen, XU Shanjin, HAN Guofeng, LI Chunmei. Effect of Different Crude Protein Levels of Artificial Crop Milk on Growth Performance,Serum Antioxidant Level and Intestinal Development of Squabs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1545-1554.
[10]	YAO Min, SHI Bomei, HUANG Tinghua. A Preliminary Research of the Regulation of MAPK-CDK6-RB Pathway by Salmonella SptP in Macrophages [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1187-1198.
[11]	XIANG Caixia, WANG Xiangguo, LI Junmei, ZHI Feijie, FANG Jiaoyang, ZHENG Weifang, CHEN Jialu, JIN Yaping, WANG Aihua. The Influence of Brucella Type IV Secretes System Effector Protein VceC on Endoplasmic Reticulum Stress and Gonadal Hormone Secretory in Goat Trophoblast Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1210-1220.
[12]	HE Xianjing, LIU Jiao, WANG Zhihui, WU Rui, GUO Donghua. Adhesion Characterization of 43K OMP in Fusobacterium necrophorum subsp. necrophorum [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 726-735.
[13]	LI Guangxing, CHEN Yang, CHEN Kaiting, WU Menglin, ZHANG Di, HUANG Xiaodan. Di (2-ethylhexyl) Phthalate Induces the Apoptosis and Necroptosis of HD11 Cells through the ROS/PTEN/PI3K/AKT Axis [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5240-5251.
[14]	TAO Jie, LI Benqiang, CHENG Jinghua, SHI Ying, LIU Peihong, LIU Huili. Differential Analysis and the Antibiotic Resistance Genes Prediction of Gut Microbiota in Pigeon [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5293-5300.
[15]	DU Haidong, NA Renhua. Research Progress on Physiological Metabolism and Microbial Changes of Ruminants During Gestation and Lactation and Their Effects on Offspring Development [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4458-4467.