猪丁型冠状病毒编码蛋白结构与功能研究进展

doi:10.11843/j.issn.0366-6964.2025.08.012

摘要/Abstract

摘要：

猪丁型冠状病毒(PDCoV)是一种新型猪肠道致病性冠状病毒，引起哺乳仔猪水样腹泻、呕吐和脱水性死亡，给养猪业造成重大经济损失。研发有效的疫苗和药物成为防控PDCoV的重要策略。PDCoV基因组编码多种类型的蛋白，它们在调控病毒复制和宿主抗病毒免疫中发挥着重要作用，研究PDCoV的编码蛋白有利于揭示病毒入侵宿主的分子机制。本文现结合国内外最新文献进展，对PDCoV编码的结构蛋白、非结构蛋白和辅助蛋白的结构特征与具体功能等进行综述，为抗冠状病毒药物和疫苗的研发提供参考。

关键词: 猪丁型冠状病毒, 编码蛋白, 分子机制, 抗病毒药物

Abstract:

Porcine deltacoronavirus (PDCoV) is a novel porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and dehydrating death in lactating piglets, resulting in significant economic losses to the swine industry. The development of effective vaccines and drugs has become an important strategy to prevent and control the PDCoV. The PDCoV genome encodes several types of proteins that play important roles in viral replication and host antiviral immunity, and the study of the proteins encoded by PDCoV is conducive to revealing the mechanism of viral invasion into the host. In this paper, the structural characteristics and specific functions of structural proteins, nonstructural proteins and accessory proteins encoded by PDCoV are summarized based on the latest literature advances at home and abroad, so as to provide reference for the development of anticoronaviral drugs and vaccines.

Key words: porcine deltacoronavirus, encoded proteins, molecular mechanism, antiviral drugs

中图分类号:

S852.659.6

陶丽寒, 林翠, 吴诚诚, 康昭风, 黄建珍. 猪丁型冠状病毒编码蛋白结构与功能研究进展[J]. 畜牧兽医学报, 2025, 56(8): 3678-3689.

TAO Lihan, LIN Cui, WU Chengcheng, KANG Zhaofeng, HUANG Jianzhen. Research Progress on the Structure and Function of Proteins Encoded by Porcine Deltacoronavirus[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(8): 3678-3689.

图/表 5

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