氧化应激对母畜子宫及妊娠影响的研究进展

doi:10.11843/j.issn.0366-6964.2024.12.004

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (12): 5368-5378.doi: 10.11843/j.issn.0366-6964.2024.12.004

氧化应激对母畜子宫及妊娠影响的研究进展

孟亚轩¹^,²^,³(), 刘彦²^,³, 韦兴茹⁴, 陈国顺¹^,*(), 冯涛¹^,²^,³^,*()

1. 甘肃农业大学动物科学技术学院, 兰州 730070
2. 北京市农林科学院畜牧兽医研究所, 北京 100097
3. 北京市农林科学院-美国俄克拉荷马州立大学动物科学联合实验室, 北京 100097
4. 北京市饲料工业协会, 北京 100107

收稿日期:2024-05-20 出版日期:2024-12-23 发布日期:2024-12-27
通讯作者: 陈国顺,冯涛 E-mail:18793606358@163.com;chengs@gsau.edu.cn;fengtao@baafs.net.cn
作者简介:孟亚轩(2000-), 女, 甘肃金昌人, 硕士生, 主要从事繁殖营养调控研究, E-mail: 18793606358@163.com
基金资助:
国家自然科学基金(31972575);北京市农林科学院课题(CZZJ202205)

Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock

MENG Yaxuan¹^,²^,³(), LIU Yan²^,³, WEI Xingru⁴, CHEN Guoshun¹^,*(), FENG Tao¹^,²^,³^,*()

1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China
2. Institute of Animal Husbandry and Veterinary Medicine (IAHVM), Beijing Academy of Agriculture and Forestry Sciences (BAAFS), Beijing 100097, China
3. Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resource of Oklahoma State University, Beijing 100097, China
4. Beijing Feed Industry Association, Beijing 100107, China

Received:2024-05-20 Online:2024-12-23 Published:2024-12-27
Contact: CHEN Guoshun, FENG Tao E-mail:18793606358@163.com;chengs@gsau.edu.cn;fengtao@baafs.net.cn

摘要/Abstract

摘要：

氧化应激是细胞内外环境变化导致产生过多活性氧的状态，在调控子宫功能中发挥着重要作用。近年来，研究表明氧化应激可以通过影响子宫内生殖激素、免疫反应、调节子宫环境和细胞信号传导等途径调控母畜子宫功能。此外，过度氧化应激会损害母体和胎盘功能，与子宫内膜癌、先兆子痫、妊娠期糖尿病和宫内生长受限等生殖疾病的形成关系密切。本文综述了近年来关于氧化应激调控母畜子宫功能的研究进展，旨在深入了解氧化应激对母畜子宫功能的影响，为提高母畜繁殖效率提供理论指导和实践应用。

关键词: 氧化应激, 母畜, 子宫, 激素, 炎症, 生殖疾病

Abstract:

Oxidative stress is a state of excessive reactive oxygen species produced by changes of intracellular and extracellular environment, which plays an important role in the regulation of uterine function. In recent years, studies have shown that oxidative stress can regulate the function of the uterus by affecting reproductive hormones, immune responses, regulating uterine environment and cell signaling. In addition, excessive oxidative stress can impair maternal and placental function, closely related to reproductive diseases such as endometrial carcinoma, pre-eclampsia, gestational diabetes mellitus, and intrauterine growth retardation. This paper reviewed the research progress on the regulation of oxidative stress on the uterine function of female livestock in recent years, in order to better understanding the effect of oxidative stress on the uterine function of female animals, providing new theoretical guidance and practical application for improving the reproduction efficiency of female livestock.

Key words: oxidative stress, female livestock, uterus, hormone, inflammation, reproductive disease

中图分类号:

S814.1

孟亚轩, 刘彦, 韦兴茹, 陈国顺, 冯涛. 氧化应激对母畜子宫及妊娠影响的研究进展[J]. 畜牧兽医学报, 2024, 55(12): 5368-5378.

MENG Yaxuan, LIU Yan, WEI Xingru, CHEN Guoshun, FENG Tao. Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(12): 5368-5378.

参考文献 107

1	YOSHIKAWA T , YOU F . Oxidative stress and bio-regulation[J]. Int J Mol Sci, 2024, 25 (6): 3360. doi: 10.3390/ijms25063360
2	ZHANG Y H , ZHAO W , XU H F , et al. Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome[J]. J Physiol, 2019, 597 (15): 3927- 3950. doi: 10.1113/JP277879
3	SANG Y F , LI Y H , XU L , et al. Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases[J]. Acta Biochim Biophys Sin (Shanghai), 2020, 52 (2): 105- 115.
4	KAJIHARA T , JONES M , FUSI L , et al. Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization[J]. Mol Endocrinol, 2006, 20 (10): 2444- 2455. doi: 10.1210/me.2006-0118
5	SHAITO A , ARAMOUNI K , ASSAF R , et al. Oxidative stress-induced endothelial dysfunction in cardiovascular diseases[J]. Front Biosci (Landmark Ed), 2022, 27 (3): 105. doi: 10.31083/j.fbl2703105
6	YAN F , ZHAO Q , LI Y , et al. The role of oxidative stress in ovarian aging: a review[J]. J Ovarian Res, 2022, 15 (1): 100. doi: 10.1186/s13048-022-01032-x
7	BATÓG G , DOŁOTO A , BAĄK E , et al. The interplay of oxidative stress and immune dysfunction in Hashimoto's thyroiditis and polycystic ovary syndrome: a comprehensive review[J]. Front Immunol, 2023, 14, 1211231. doi: 10.3389/fimmu.2023.1211231
8	SUGINO N , SHIMAMURA K , TAKIGUCHI S , et al. Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy[J]. Hum Reprod, 1996, 11 (5): 1073- 1078. doi: 10.1093/oxfordjournals.humrep.a019299
9	FRANCO C , SCIATTI E , FAVERO G , et al. Essential hypertension and oxidative stress: novel future perspectives[J]. Int J Mol Sci, 2022, 23 (22): 14489. doi: 10.3390/ijms232214489
10	ALBRAHIM T , ALANGRY R , ALOTAIBI R , et al. Effects of regular exercise and intermittent fasting on neurotransmitters, inflammation, oxidative stress, and brain-derived neurotrophic factor in cortex of ovariectomized rats[J]. Nutrients, 2023, 15 (19): 4270. doi: 10.3390/nu15194270
11	DEMIRCI-ÇEKIÇ S , ÖZKAN G , AVAN A N , et al. Biomarkers of oxidative stress and antioxidant defense[J]. J Pharm Biomed Anal, 2022, 209, 114477. doi: 10.1016/j.jpba.2021.114477
12	ZHOU K , XIAO J , WANG H , et al. Estradiol regulates oxidative stress and angiogenesis of myocardial microvascular endothelial cells via the CDK1/CDK2 pathway[J]. Heliyon, 2023, 9 (3): e14305. doi: 10.1016/j.heliyon.2023.e14305
13	GUO Y S , CAI X S , LU H W , et al. 17β-estradiol promotes apoptosis of HepG2 cells caused by oxidative stress by increasing Foxo3a phosphorylation[J]. Front Pharmacol, 2021, 12, 607379. doi: 10.3389/fphar.2021.607379
14	DOMAZETOVIC V , FALSETTI I , CIUFFI S , et al. Effect of oxidative stress-induced apoptosis on active FGF23 levels in MLO-Y4 cells: the protective role of 17-β-estradiol[J]. Int J Mol Sci, 2022, 23 (4): 2103. doi: 10.3390/ijms23042103
15	GALMÉS-PASCUAL B M , MARTÁNEZ-CIGNONI M R , MORÁN-COSTOYA A , et al. 17β-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance[J]. Free Radic Biol Med, 2020, 150, 148- 160. doi: 10.1016/j.freeradbiomed.2020.02.016
16	TIAN X , GAO Z L , YIN D Y , et al. 17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway[J]. Steroids, 2023, 191, 109160. doi: 10.1016/j.steroids.2022.109160
17	HAJIALIZADEH Z , KHAKSARI M . The protective effects of 17-β estradiol and SIRT1 against cardiac hypertrophy: a review[J]. Heart Fail Rev, 2022, 27 (2): 725- 738. doi: 10.1007/s10741-021-10171-0
18	XU Y Y , XU H , YIN X P , et al. 17 β-Estradiol alleviates oxidative damage in osteoblasts by regulating miR-320/RUNX2 signaling pathway[J]. J Biosci, 2021, 46 (4): 113. doi: 10.1007/s12038-021-00236-5
19	LIEHR J G . Genotoxic effects of estrogens[J]. Mutat Res/Rev Genet Toxicol, 1990, 238 (3): 269- 276. doi: 10.1016/0165-1110(90)90018-7
20	NASIADEK M , SKRZYPIŃSKA-GAWRYSIAK M , DARAGÓ A , et al. Involvement of oxidative stress in the mechanism of cadmium-induced toxicity on rat uterus[J]. Environ Toxicol Pharmacol, 2014, 38 (2): 364- 373. doi: 10.1016/j.etap.2014.07.007
21	JUN Y W , ALBARRAN E , WILSON D L , et al. Fluorescence imaging of mitochondrial DNA base excision repair reveals dynamics of oxidative stress responses[J]. Angew Chem Int Ed, 2022, 61 (6): e202111829. doi: 10.1002/anie.202111829
22	AL-GUBORY K H , BOLIFRAUD P , GARREL C . Regulation of key antioxidant enzymatic systems in the sheep endometrium by ovarian steroids[J]. Endocrinology, 2008, 149 (9): 4428- 4434. doi: 10.1210/en.2008-0187
23	SINGH D , SHARMA M K , PANDEY R S . Changes in superoxide dismutase activity and estradiol-17 beta content in follicles of different sizes from ruminants[J]. Indian J Exp Biol, 1998, 36 (4): 358- 360.
24	LALORAYA M , JAIN S , THOMAS M , et al. Estrogen surge: a regulatory switch for superoxide radical generation at implantation[J]. IUBMB Life, 1996, 39 (5): 933- 940. doi: 10.1080/15216549600201082
25	VELUTHAKAL R , ESPARZA D , HOOLACHAN J M , et al. Mitochondrial dysfunction, oxidative stress, and inter-organ miscommunications in T2D progression[J]. Int J Mol Sci, 2024, 25 (3): 1504. doi: 10.3390/ijms25031504
26	DURANTI G . Oxidative stress and skeletal muscle function[J]. Int J Mol Sci, 2023, 24 (12): 10227. doi: 10.3390/ijms241210227
27	ALESE M O , BAMISI O D , ALESE O O . Progesterone modulates cadmium-induced oxidative stress and inflammation in hepatic tissues of Wistar rats[J]. Int J Clin Exp Pathol, 2021, 14 (10): 1048- 1055.
28	FENG L P , ALLEN T K , MARINELLO W P , et al. Roles of progesterone receptor membrane component 1 in oxidative stress-induced aging in chorion cells[J]. Reprod Sci, 2019, 26 (3): 394- 403. doi: 10.1177/1933719118776790
29	LALORAYA M , KUMAR G P , LALORAYA M M . Histochemical study of superoxide dismutase in the ovary of the rat during the oestrous cycle[J]. J Reprod Fert, 1989, 86 (2): 583- 587. doi: 10.1530/jrf.0.0860583
30	MANCINI A , DI SEGNI C , RAIMONDO S , et al. Thyroid hormones, oxidative stress, and inflammation[J]. Mediators Inflamm, 2016, 2016, 6757154.
31	HUANG P S , WANG C S , YEH C T , et al. Roles of thyroid hormone-associated microRNAs affecting oxidative stress in human hepatocellular carcinoma[J]. Int J Mol Sci, 2019, 20 (20): 5220. doi: 10.3390/ijms20205220
32	BUCZYŃSKA A , SIDORKIEWICZ I , ROGUCKI M , et al. Oxidative stress and radioiodine treatment of differentiated thyroid cancer[J]. Sci Rep, 2021, 11 (1): 17126. doi: 10.1038/s41598-021-96637-5
33	AGHAJANOVA L , STAVREUS-EVERS A , LINDEBERG M , et al. Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology[J]. Fertil Steril, 2011, 95 (1): 230- 237.e2. doi: 10.1016/j.fertnstert.2010.06.079
34	HULCHIY M , ZHANG H , CLINE J M , et al. Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment[J]. Menopause, 2012, 19 (11): 1253- 1259. doi: 10.1097/gme.0b013e318252e450
35	FEDAIL J S , ZHENG K Z , WEI Q W , et al. Roles of thyroid hormones in follicular development in the ovary of neonatal and immature rats[J]. Endocrine, 2014, 46 (3): 594- 604. doi: 10.1007/s12020-013-0092-y
36	ÖNER J , ÖNER H . Immunodetection of thyroid hormone receptor (alpha1/alpha2) in the rat uterus and oviduct[J]. Acta Histochem Cytochem, 2007, 40 (3): 77- 81. doi: 10.1267/ahc.06026
37	KONG L F , WEI Q W , FEDAIL J S , et al. Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats[J]. J Reprod Dev, 2015, 61 (3): 219- 227. doi: 10.1262/jrd.2014-129
38	STAVREUS EVERS A . Paracrine interactions of thyroid hormones and thyroid stimulation hormone in the female reproductive tract have an impact on female fertility[J]. Front Endocrinol (Lausanne), 2012, 3, 50.
39	VILLANUEVA I , ALVA-SÁNCHEZ C , PACHECO-ROSADO J . The role of thyroid hormones as inductors of oxidative stress and neurodegeneration[J]. Oxid Med Cell Longev, 2013, 2013, 218145.
40	REHMAN R , RAJPAR H I , ASHRAF M , et al. Role of oxidative stress and altered thyroid hormones in unexplained infertility[J]. J Pak Med Assoc, 2020, 70 (8): 1345- 1349.
41	KRAVCHENKO V , ZAKHARCHENKO T . Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases[J]. Front Endocrinol (Lausanne), 2023, 14, 1225494. doi: 10.3389/fendo.2023.1225494
42	SUGINO N . The role of oxygen radical-mediated signaling pathways in endometrial function[J]. Placenta, 2007, 28 (Suppl 1): S133- S136.
43	DAS A , ROYCHOUDHURY S . Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles[J]. Adv Exp Med Biol, 2022, 1358, 9- 40.
44	RUDER E H , HARTMAN T J , BLUMBERG J , et al. Oxidative stress and antioxidants: exposure and impact on female fertility[J]. Hum Reprod Update, 2008, 14 (4): 345- 357. doi: 10.1093/humupd/dmn011
45	BAI X C , ZHENG L W , LI D D , et al. Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review[J]. Reprod Biol Endocrinol, 2021, 19 (1): 122. doi: 10.1186/s12958-021-00802-4
46	JIANG N X , LI X L . The disorders of endometrial receptivity in PCOS and its mechanisms[J]. Reprod Sci, 2022, 29 (9): 2465- 2476. doi: 10.1007/s43032-021-00629-9
47	HU M , ZHANG Y , LU L , et al. Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway[J]. FEBS Lett, 2022, 596 (6): 806- 825. doi: 10.1002/1873-3468.14289
48	SONG P , LIU C , SUN M , et al. Transcription Factor Nrf2 Modulates Lipopolysaccharide-Induced Injury in Bovine Endometrial Epithelial Cells[J]. Int J Mol Sci, 2023, 24 (13): 11221. doi: 10.3390/ijms241311221
49	CHEN M X , LI J , ZHANG B , et al. Uterine insulin sensitivity defects induced embryo implantation loss associated with mitochondrial dysfunction-triggered oxidative stress[J]. Oxid Med Cell Longev, 2021, 2021, 6655685. doi: 10.1155/2021/6655685
50	BELLEZZA I , GIAMBANCO I , MINELLI A , et al. Nrf2-Keap1 signaling in oxidative and reductive stress[J]. Biochim Biophys Acta Mol Cell Res, 2018, 1865 (5): 721- 733. doi: 10.1016/j.bbamcr.2018.02.010
51	TANIKAWA N , OHTSU A , KAWAHARA-MIKI R , et al. Age-associated mRNA expression changes in bovine endometrial cells in vitro[J]. Reprod Biol Endocrinol, 2017, 15 (1): 63. doi: 10.1186/s12958-017-0284-z
52	TEKLENBURG G , SALKER M , MOLOKHIA M , et al. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation[J]. PLoS One, 2010, 5 (4): e10258. doi: 10.1371/journal.pone.0010258
53	ZHANG H Q , DAVIES K J A , FORMAN H J . Oxidative stress response and Nrf2 signaling in aging[J]. Free Radic Biol Med, 2015, 88, 314- 336. doi: 10.1016/j.freeradbiomed.2015.05.036
54	LI Z Q , ZHENG C N , LIU H T , et al. A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC[J]. Aging (Albany NY), 2023, 15 (24): 14957- 14984.
55	CARNEVALE E M , GINTHER O J . Relationships of age to uterine function and reproductive efficiency in mares[J]. Theriogenology, 1992, 37 (5): 1101- 1115. doi: 10.1016/0093-691X(92)90108-4
56	AKIYAMA Y , IVANOV P . Oxidative stress, transfer RNA metabolism, and protein synthesis[J]. Antioxid Redox Signal, 2024, 40 (10-12): 715- 735. doi: 10.1089/ars.2022.0206
57	SALAMONSEN L A , LATHBURY L J . Endometrial leukocytes and menstruation[J]. Hum Reprod Update, 2000, 6 (1): 16- 27. doi: 10.1093/humupd/6.1.16
58	KWAK-KIM J , BAO S H , LEE S K , et al. Immunological modes of pregnancy loss: inflammation, immune effectors, and stress[J]. Am J Reprod Immunol, 2014, 72 (2): 129- 140. doi: 10.1111/aji.12234
59	DYMANOWSKA-DYJAK I , TERPIŁOWSKA B , MORAWSKA-MICHALSKA I , et al. Immune dysregulation in endometriomas: implications for inflammation[J]. Int J Mol Sci, 2024, 25 (9): 4802. doi: 10.3390/ijms25094802
60	VALENZUELA-MELGAREJO F J , LAGUNAS C , CARMONA-PASTÉN F , et al. Supraphysiological role of melatonin over vascular dysfunction of pregnancy, a new therapeutic agent?[J]. Front Physiol, 2021, 12, 767684. doi: 10.3389/fphys.2021.767684
61	RUDNICKA E , SUCHTA K , GRYMOWICZ M , et al. Chronic low grade inflammation in pathogenesis of PCOS[J]. Int J Mol Sci, 2021, 22 (7): 3789. doi: 10.3390/ijms22073789
62	FALOMO M E , DEL RE B , ROSSI M , et al. Relationship between postpartum uterine involution and biomarkers of inflammation and oxidative stress in clinically healthy mares (Equus caballus)[J]. Heliyon, 2020, 6 (4): e03691. doi: 10.1016/j.heliyon.2020.e03691
63	IBRAHIM M A , ALBAHLOL I A , WANI F A , et al. Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis[J]. Chem Biol Interact, 2021, 338, 109402. doi: 10.1016/j.cbi.2021.109402
64	TANTENGCO O A G , VINK J , MEDINA P M B , et al. Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy[J]. Biol Reprod, 2021, 105 (1): 204- 216. doi: 10.1093/biolre/ioab058
65	LI X , WU H S , XING W W , et al. Short-term association of fine particulate matter and its constituents with oxidative stress, symptoms and quality of life in patients with allergic rhinitis: a panel study[J]. Environ Int, 2023, 182, 108319. doi: 10.1016/j.envint.2023.108319
66	ZULFIQAR F , NAFEES M , CHEN J J , et al. Chemical priming enhances plant tolerance to salt stress[J]. Front Plant Sci, 2022, 13, 946922. doi: 10.3389/fpls.2022.946922
67	HU X Q , SONG R , ZHANG L B . Effect of oxidative stress on the estrogen-NOS-NO-K_Ca channel pathway in uteroplacental dysfunction: its implication in pregnancy complications[J]. Oxid Med Cell Longev, 2019, 2019, 9194269.
68	WU Y , LI M , ZHANG J , et al. Unveiling uterine aging: Much more to learn[J]. Ageing Res Rev, 2023, 86, 101879. doi: 10.1016/j.arr.2023.101879
69	ÖNER-İYIDOǦAN Y , KOÇAK H , GVRDÜL F , et al. Indices of oxidative stress in eutopic and ectopic endometria of women with endometriosis[J]. Gynecol Obstet Invest, 2004, 57 (4): 214- 217. doi: 10.1159/000076691
70	WU H , XU T , CHEN T , et al. Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice[J]. Sci Total Environ, 2022, 838, 155825. doi: 10.1016/j.scitotenv.2022.155825
71	NELSON W , ADU-GYAMFI E A , CZIKA A , et al. Bisphenol A-induced mechanistic impairment of decidualization[J]. Mol Reprod Dev, 2020, 87 (8): 837- 842. doi: 10.1002/mrd.23400
72	TAMARU S , KAJIHARA T , MIZUNO Y , et al. Heparin prevents oxidative stress-induced apoptosis in human decidualized endometrial stromal cells[J]. Med Mol Morphol, 2019, 52 (4): 209- 216. doi: 10.1007/s00795-019-00220-x
73	LEITAO B , JONES M C , FUSI L , et al. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals[J]. FASEB J, 2010, 24 (5): 1541- 1551. doi: 10.1096/fj.09-149153
74	LIU A X , HE W H , YIN L J , et al. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss[J]. J Clin Endocrinol Metab, 2011, 96 (3): E493- E497. doi: 10.1210/jc.2010-2192
75	ZHANG S , LIN H Y , KONG S B , et al. Physiological and molecular determinants of embryo implantation[J]. Mol Aspects Med, 2013, 34 (5): 939- 980. doi: 10.1016/j.mam.2012.12.011
76	ZHENG H T , ZHANG H Y , CHEN S T , et al. The detrimental effects of stress-induced glucocorticoid exposure on mouse uterine receptivity and decidualization[J]. FASEB J, 2020, 34 (11): 14200- 14216. doi: 10.1096/fj.201902911RR
77	LI Y , CHEN S T , HE Y Y , et al. The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization[J]. Front Immunol, 2023, 14, 1024706. doi: 10.3389/fimmu.2023.1024706
78	TAKEZAWA Y , IWAI M , FUJIKI Y , et al. Embryonic β-catenin is required for priming of the uterus to implantation[J]. Lab Invest, 2023, 103 (3): 100026. doi: 10.1016/j.labinv.2022.100026
79	DEER E , HERROCK O , CAMPBELL N , et al. The role of immune cells and mediators in preeclampsia[J]. Nat Rev Nephrol, 2023, 19 (4): 257- 270. doi: 10.1038/s41581-022-00670-0
80	MATSUBARA K , HIGAKI T , MATSUBARA Y , et al. Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia[J]. Int J Mol Sci, 2015, 16 (3): 4600- 4614. doi: 10.3390/ijms16034600
81	NEHA K , HAIDER R , PATHAK A , et al. Medicinal prospects of antioxidants: a review[J]. Eur J Med Chem, 2019, 178, 687- 704. doi: 10.1016/j.ejmech.2019.06.010
82	MICHALAK M . Plant-derived antioxidants: significance in skin health and the ageing process[J]. Int J Mol Sci, 2022, 23 (2): 585. doi: 10.3390/ijms23020585
83	BURTON G J , CINDROVA-DAVIES T , YUNG H W , et al. HYPOXIA AND REPRODUCTIVE HEALTH: oxygen and development of the human placenta[J]. Reproduction, 2021, 161 (1): F53- F65. doi: 10.1530/REP-20-0153
84	JELIC M D , MANDIC A D , MARICIC S M , et al. Oxidative stress and its role in cancer[J]. J Cancer Res Ther, 2021, 17 (1): 22- 28. doi: 10.4103/jcrt.JCRT_862_16
85	LIU Q , YU M H , ZHANG T . Construction of oxidative stress-related genes risk model predicts the prognosis of uterine corpus endometrial cancer patients[J]. Cancers (Basel), 2022, 14 (22): 5572. doi: 10.3390/cancers14225572
86	BUKATO K , KOSTRZEWA T , GAMMAZZA A M , et al. Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers[J]. Cell Commun Signal, 2024, 22 (1): 205. doi: 10.1186/s12964-024-01583-0
87	PUNNONEN R , KUDO R , PUNNONEN K , et al. Activities of antioxidant enzymes and lipid peroxidation in endometrial cancer[J]. Eur J Cancer, 1993, 29A (2): 266- 269.
88	MONGE M , COLAS E , DOLL A , et al. Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress[J]. Carcinogenesis, 2009, 30 (8): 1288- 1297. doi: 10.1093/carcin/bgp119
89	CROSBIE EJ , KITSON SJ , MCALPINE JN , et al. Endometrial cancer[J]. Lancet, 2022, 399 (10333): 1412- 1428. doi: 10.1016/S0140-6736(22)00323-3
90	BAKHTIYAROV K , IVANTSOVA M , KUKES I , et al. Metabolomic markers of endometriosis: Prospects[J]. Georgian Med News, 2023, (340-341): 275- 279.
91	CLOWER L , FLESHMAN T , GELDENHUYS WJ , et al. Targeting Oxidative Stress Involved in Endometriosis and Its Pain[J]. Biomolecules, 2022, 12 (8): 1055. doi: 10.3390/biom12081055
92	BARDEN A E , SHINDE S , PHILLIPS M , et al. Mediators of inflammation resolution and vasoactive eicosanoids in gestational diabetes and preeclampsia[J]. J Hypertens, 2022, 40 (11): 2236- 2244. doi: 10.1097/HJH.0000000000003253
93	LIU G H , DONG Y L , WANG Z X , et al. Restraint stress delays endometrial adaptive remodeling during mouse embryo implantation[J]. Stress, 2015, 18 (6): 699- 709. doi: 10.3109/10253890.2015.1078305
94	KATERJI M , FILIPPOVA M , DUERKSEN-HUGHES P . Approaches and methods to measure oxidative stress in clinical samples: research applications in the cancer field[J]. Oxid Med Cell Longev, 2019, 2019, 1279250.
95	GRIENDLING K K , SORESCU D , LASSEGUE B , et al. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology[J]. Arterioscler Thromb Vasc Biol, 2000, 20 (10): 2175- 2183.
96	TRUJILLO M , ODLE A K , AYKIN-BURNS N , et al. Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions[J]. Biol Reprod, 2023, 108 (4): 522- 537.
97	WANG Y W , QI H , LIU Y , et al. The double-edged roles of ROS in cancer prevention and therapy[J]. Theranostics, 2021, 11 (10): 4839- 4857.
98	HUANG X J , JIA L Y , JIA Y H , et al. sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice[J]. Cytokine, 2023, 166, 156190.
99	LI H M , REN J , LI Y S , et al. Oxidative stress: the nexus of obesity and cognitive dysfunction in diabetes[J]. Front Endocrinol (Lausanne), 2023, 14, 1134025.
100	OGUNTIBEJU O O . Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links[J]. Int J Physiol Pathophysiol Pharmacol, 2019, 11 (3): 45- 63.
101	CONTRERAS-DUARTE S , CARVAJAL L , GARCHITORENA M J , et al. Gestational diabetes mellitus treatment schemes modify maternal plasma cholesterol levels dependent to women's weight: possible impact on feto-placental vascular function[J]. Nutrients, 2020, 12 (2): 506.
102	BURTON G J , JAUNIAUX E . Pathophysiology of placental-derived fetal growth restriction[J]. Am J Obstet Gynecol, 2018, 218 (2S): S745- S761.
103	MANDÒ C , DE PALMA C , STAMPALIJA T , et al. Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia[J]. Am J Physiol Endocrinol Metab, 2014, 306 (4): E404- E413.
104	CHANDRAHARAN E , GHI T , FIENI S , et al. Optimizing the management of acute, prolonged decelerations and fetal bradycardia based on the understanding of fetal pathophysiology[J]. Am J Obstet Gynecol, 2023, 228 (6): 645- 656.
105	OKE S L , HARDY D B . The role of cellular stress in intrauterine growth restriction and postnatal dysmetabolism[J]. Int J Mol Sci, 2021, 22 (13): 6986.
106	DAVY P , NAGATA M , BULLARD P , et al. Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta[J]. Placenta, 2009, 30 (6): 539- 542.
107	ZHANG H , ZHENG Y , LIU X , et al. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes[J]. Environ Int, 2023, 173, 107806.

[1]	杨硕, 霍敏, 苏子轩, 石玉祥. 线粒体质量控制对畜禽氧化应激影响的研究进展[J]. 畜牧兽医学报, 2024, 55(9): 3769-3776.
[2]	袁紫金, 王婉昕, 邢娅, 李家惠, 薛颖, 葛晶, 赵敏孟, 刘龙, 龚道清, 耿拓宇. HDLBP通过调控氧化应激水平和炎性因子表达参与鹅肥肝的形成[J]. 畜牧兽医学报, 2024, 55(9): 3897-3913.
[3]	王忆, 巩建飞, 衡诺, 胡樱凡, 王蕊, 王欢, 朱妮, 何维, 胡智辉, 郝海生, 朱化彬, 赵善江. 褪黑素通过改善线粒体动力学缓解棕榈酸诱导的牛子宫内膜上皮细胞损伤[J]. 畜牧兽医学报, 2024, 55(9): 3978-3987.
[4]	刘馨蔓, 周鸿缘, 桑锐, 葛冰洁, 闫可心, 王巍, 于明弘, 刘晓童, 邱谦, 张雪梅. 蒲公英甾醇对AFB₁性肝损伤肉鸡肝组织氧化应激的影响[J]. 畜牧兽医学报, 2024, 55(9): 4141-4152.
[5]	周佳丽, 丁宝隆, 马子明, 淡新刚, 赵洪喜. 奶牛子宫内膜炎与胃肠微生物相关性及益生菌作用的研究进展[J]. 畜牧兽医学报, 2024, 55(8): 3321-3330.
[6]	鲜婷婷, 刘彦, 曹忻, 冯涛. 母猪子宫内膜炎阴道菌群与血清促炎细胞因子的变化及其相关性分析[J]. 畜牧兽医学报, 2024, 55(8): 3688-3698.
[7]	孟亚轩, 刘彦, 王晶, 陈国顺, 冯涛. 氧化应激对母畜卵巢功能影响的研究进展[J]. 畜牧兽医学报, 2024, 55(7): 2825-2835.
[8]	李京宇, 陈金铭, 张明一, 赵姗姗, 陶德良, 宋军科, 杨新, 樊莹莹, 赵光辉. 犬新孢子虫miRNAs的鉴定与分析[J]. 畜牧兽医学报, 2024, 55(7): 3085-3093.
[9]	褚婷婷, 张晓宇, 孙磊, 童嘉顺, 张磊, 宋宇轩. 家畜子宫内膜纤维化的细胞分子机制研究进展[J]. 畜牧兽医学报, 2024, 55(6): 2334-2344.
[10]	王选艺, 孙亚伟, 龙雨薇, 王俪颖, 周渝新, 李娜, 马雪连, 赵红琼, 姚刚. 屡配不孕母牛FOXP3、FSHR、FMR1基因多态性与生殖激素相关性分析[J]. 畜牧兽医学报, 2024, 55(6): 2727-2740.
[11]	杨小峰, 秦小伟, 吕丽华. MNQ的一种衍生物对LPS体外诱导的牛卵巢卵泡颗粒细胞炎性损伤的保护作用[J]. 畜牧兽医学报, 2024, 55(5): 2032-2041.
[12]	刘思弟, 马贲, 郑言, 邱云桥, 姚泽龙, 曹中赞, 栾新红. 肠道菌群调控动物肠道黏膜免疫和炎症的研究进展[J]. 畜牧兽医学报, 2024, 55(4): 1423-1431.
[13]	李菲菲, 张晨淼, 童津津, 蒋林树. 线粒体自噬调节NLRP3炎症小体活性改善动物健康的作用机制[J]. 畜牧兽医学报, 2024, 55(4): 1446-1455.
[14]	戴帆, 刘占有, 张旭阳, 李武. 乌头酸脱羧酶1对BCG诱导巨噬细胞炎症反应的调控作用研究[J]. 畜牧兽医学报, 2024, 55(4): 1696-1706.
[15]	章心婷, 邱文粤, 庞晓玥, 苏依曼, 叶嘉莉, 黄健佳, 周水莲, 唐兆新, 王荣梅, 苏荣胜. 积雪草酸通过抑制氧化应激和铁死亡减轻脂多糖诱导的肉鸡心肌损伤的研究[J]. 畜牧兽医学报, 2024, 55(4): 1787-1799.

氧化应激对母畜子宫及妊娠影响的研究进展

Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 107

相关文章 15

编辑推荐

Metrics

本文评价