麻杏石甘口服液治疗肉鸡感染鸡毒支原体的效果评价

doi:10.11843/j.issn.0366-6964.2023.12.035

摘要/Abstract

摘要： 旨在验证麻杏石甘口服液对人工感染鸡毒支原体治疗效果。将87只1日龄健康鸡按常规饲养至20日龄,随机分为感染对照组、空白对照组和治疗组。空白对照组正常饲喂,不感染。感染对照组和治疗组的试验鸡通过滴鼻、点眼、气囊注射鸡毒支原体M17菌液共1.5 mL(10⁹ CCU·mL^-1),1次·d^-1,连续感染4 d。在感染的第5天(D1),治疗组经每升水1.5 mL麻杏石甘口服液饲喂治疗,连用5 d,停药后观察6 d。观察给药前1 d(D0)~D11各组鸡的呼吸、咳嗽、流涕、甩鼻、采食和精神状态等临床症状并进行评分,计算临床症状总评分、痊愈率、有效率和无效率。于D0和D12称量试验鸡体重,计算平均增重。分别于D2、D6、D12,每组剖检试验鸡6只,观察肺和气囊病理变化,并采集肺进行组织病理学观察。结果显示:治疗组临床症状总评分在D3开始明显降低(P<0.05);治疗组在D2、D6、D12,肺和气囊病变评分均显著低于感染对照组(P<0.05),肺的组织病理学病变评分也显著低于感染对照组(P<0.05),空白对照组未见异常;治疗组的痊愈率为76.5%,有效率94.1%,无效率为5.9%。感染对照组和治疗组的平均增重显著低于空白对照组(P<0.05)。麻杏石甘口服液可明显改善肉鸡气囊和肺组织病理损伤,对人工感染鸡毒支原体的肉鸡有较好的治疗效果。

关键词: 麻杏石甘口服液, 鸡毒支原体, 治疗

Abstract: The study was conducted to verify the therapeutic effect of Maxing Shigan Oral Liquid on artificial infection of Mycoplasma gallisepticum. Eighty-seven 1-day-old healthy chickens were routinely raised to 20 days of age and randomly divided into infection control group, blank control group and treatment group. The blank control group was fed normally without infection. The chickens in the infection control group and the treatment group were injected with 1.5 mL (10⁹ CCU·mL^-1) of Mycoplasma gallisepticum M17 bacterial solution by nasal drip, eye drop and air sac injection, once a day for 4 days. On the 5th day (D1) of infection, the treatment group was fed with 1.5 mL Maxing Shigan Oral Liquid per liter of water for 5 days, and observed for 6 days after drug withdrawal. The clinical symptoms such as respiration, cough, runny nose, nasal throwing, feeding and mental state of chickens in each group were observed and scored from 1 day (D0) to D11 days before administration. The total score of clinical symptoms, cure rate, effective rate and inefficiency were calculated. The body weight of the chickens was weighed on D0 and D12, and the average weight gain was calculated. On D2, D6 and D12 days, 6 chickens in each group were sacrificed to observe the pathological changes of lung and air sac, and the lungs were collected for histopathological observation. The total score of clinical symptoms in the treatment group decreased significantly on D3 (P<0.05). On D2, D6 and D12, the scores of lung and air sac lesions in the treatment group were significantly lower than those in the infection control group (P<0.05), and the histopathological lesion score of the lung was also significantly lower than that in the infection control group (P<0.05). There was no abnormality in the blank control group. The cure rate of the treatment group was 76.5%, the effective rate was 94.1%, and the ineffective rate was 5.9%. The average weight gain of the infection control group and the treatment group was significantly lower than that of the blank control group (P<0.05). Maxing Shigan oral liquid can significantly improve the pathological damage of air sac and lung tissue of broilers, and has a good therapeutic effect on broilers artificially infected with Mycoplasma gallisepticum.

Key words: Maxing Shigan oral liquid, Mycoplasma gallisepticum, treatment

中图分类号:

S853.9

雷亚萍, 周世伟, 滕雨萌, 农碧丹, 庞晓敏, 张诣, 刘晓丽, 王玉莲, 胡薛英. 麻杏石甘口服液治疗肉鸡感染鸡毒支原体的效果评价[J]. 畜牧兽医学报, 2023, 54(12): 5264-5274.

LEI Yaping, ZHOU Shiwei, TENG Yumeng, NONG Bidan, PANG Xiaomin, ZHANG Yi, LIU Xiaoli, WANG Yulian, HU Xueying. Effect Evaluation of Maxing Shigan Oral Liquid in the Treatment of Broiler Chicken Infected with Mycoplasma gallisepticum[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5264-5274.

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