鹿茸逆向成骨的研究进展

doi:10.11843/j.issn.0366-6964.2023.06.003

摘要/Abstract

摘要： 鹿茸作为鹿科动物的一种骨质性器官,基于干细胞进行年周期性再生,独特的生物学特性使其逐渐成为生物学、医学等领域的理想模型。鹿茸的骨化与体内性激素水平变化密切相关:在鹿机体性激素水平低、肋骨骨质流失的生理环境下,鹿茸的生长速度高达2.7 cm·d^-1,一边生长一边骨化;随后性激素水平上升,鹿茸便进入快速骨化期,3个月的时间可形成重达30 kg的骨质性组织。鹿茸能够在体骨骼骨质大规模流失且低水平性激素的内分泌条件下实现快速成骨的现象称之为鹿茸逆向成骨。本文从细胞分化、激素、成骨、破骨和细胞因子角度对鹿茸逆向成骨的研究现状和发生机制进行了综述,旨在探索鹿茸逆向成骨机制,为提高产茸量与动物福利健康提供借鉴与参考。

关键词: 鹿茸, 逆向成骨, 骨质疏松, 细胞因子, 激素

Abstract: As an osseous organ of deer family, deer antler undergoes annual cyclic regeneration based on stem cells, and its unique biological properties have gradually made it an ideal model for biology, medicine and other fields. Antler ossification is closely related to changes in sex hormone levels in the body: Under the physiological environment of low sex hormone levels and rib bone loss in deer, antlers grow at a rate of up to 2.7 cm·d^-1, and ossifying as they grow; Then sex hormone levels rise and antlers enter a period of rapid ossification, forming bony tissues weighing more than 30 kg in just three months. This phenomenon that antler can achieve rapid osteogenesis under the endocrine conditions of massive body bone loss and low levels of sex hormones, which called antler reverse osteogenesis. This paper reviewed the current research status and occurrence mechanism of antler reverse osteogenesis from the perspectives of cell differentiation, hormone, osteogenesis, osteolysis and cytokines, with the aim of investigating the mechanisms of antler reverse osteogenesis and providing a reference for improving antler production and animal welfare and health.

Key words: deer antler, reverse osteogenesis, osteoporosis, cytokines, hormone

中图分类号:

S865.42

邢宝瑞, 刘振, 赵海平, 马泽芳, 李勋胜, 周珏, 孙红梅. 鹿茸逆向成骨的研究进展[J]. 畜牧兽医学报, 2023, 54(6): 2231-2240.

XING Baorui, LIU Zhen, ZHAO Haiping, MA Zefang, LI Xunsheng, ZHOU Jue, SUN Hongmei. Research Progress in Reverse Osteogenesis of Deer Antler[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2231-2240.

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