细菌外膜囊泡结构、分泌特性及致病机制

doi:10.11843/j.issn.0366-6964.2024.03.011

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (3): 971-983.doi: 10.11843/j.issn.0366-6964.2024.03.011

细菌外膜囊泡结构、分泌特性及致病机制

高远集^1,2,3, 刘畅^1,2,3, 陈淼¹, 陈松彪^1,2,3, 张俊峰⁴, 李静^1,2,3, 贾艳艳^1,2,3, 廖成水^1,2,3, 郭荣显^1,2,3, 丁轲^1,2,3, 余祖华^1,2,3*, 尚珂^1,2,3*

1. 河南科技大学动物科技学院/功能微生物与畜禽健康实验室, 洛阳 471003;
2. 洛阳市活载体生物材料与动物疫病防控重点实验室, 洛阳 471003;
3. 河南科技大学动物疫病与公共卫生重点实验室, 洛阳 471003;
4. 河南科技大学医学技术与工程学院, 洛阳 471003

收稿日期:2023-06-27 出版日期:2024-03-23 发布日期:2024-03-27
通讯作者: 尚珂,主要从事畜禽病原微生物学研究,E-mail:shangke0624@163.com;余祖华,主要从事动物传染病学研究,Tel:0379-64280348,E-mail:yzhd05@163.com
作者简介:高远集(1997-),男,河南淇县人,硕士,主要从事功能微生物与畜禽健康研究,E-mail:987086098@qq.com;刘畅(1998-),女,河南巩义人,硕士,主要从事功能微生物与畜禽健康研究,E-mail:2079838050@qq.com。
基金资助:
河南科技大学博士研究启动专项基金（13480102）；河南省自然科学基金资助项目（232300421263）；河南省科技研发计划联合基金（232103810029）

Structure, Secretory Characteristics, and Pathogenic Mechanism of Bacterial Outer Membrane Vesicles

GAO Yuanji^1,2,3, LIU Chang^1,2,3, CHEN Miao¹, CHEN Songbiao^1,2,3, ZHANG Junfeng⁴, LI Jing^1,2,3, JIA Yanyan^1,2,3, LIAO Chengshui^1,2,3, GUO Rongxian^1,2,3, DING Ke^1,2,3, YU Zuhua^1,2,3*, SHANG Ke^1,2,3*

1. College of Animal Science and Technology/Laboratory of Functional Microbiology and Animal Health, Henan University of Science and Technology, Luoyang 471003, China;
2. Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Luoyang 471003, China;
3. The Key Laboratory of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang 471003, China;
4. College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471003, China

Received:2023-06-27 Online:2024-03-23 Published:2024-03-27

摘要/Abstract

摘要： 外膜囊泡（outer membrane vesicles，OMVs）是革兰阴性菌在生长过程中释放到胞外的囊泡状结构，被认为是细菌的"远程武器"，其功能主要是攻击宿主组织并帮助细菌定植、损害宿主细胞功能、调节宿主的防御，因此OMVs在细菌致病过程中发挥着重要作用。囊泡中的物质通过与细菌释放出的自诱导物化学信号分子结合，可以驱使细菌或者囊泡在内环境中发挥特殊功能，如群体感应、生物膜形成、获取营养、抗生素抗性、应激反应、对抗其它微生物的竞争或防御、微生物群落状态、核酸转移、水平基因转移、毒素和毒力因子的递送等，且在细菌生长周期发挥着不可或缺的作用。本文主要综述OMVs结构、分泌特性及其致病机制的最新研究进展，为深入研究细菌的致病机制以及开发新的抗菌策略提供理论指导。

关键词: 细菌, 外膜囊泡, 结构, 分泌特性, 致病机制

Abstract: Bacterial outer membrane vesicles (OMVs) are vesicle-like structures released by Gram-negative bacteria during their growth. OMVs can be considered as "long-range weapons" of bacteria. OMVs play an important role in bacterial pathogenesis, which functions are to attack host tissues and help bacterial pathogens establish their biological niche, damage host cell functions, and regulate host defense. The substances secreted by bacteria into vesicles can drive special functions in the environment through combination, such as quorum sensing communication, biofilm formation, nutrition acquisition, antibiotic resistance, stress response, competition or defense against other microorganisms, environment, microbial community status, nucleic acid transfer, horizontal gene transfer, delivery of toxins and virulence factors. These characteristics play an indispensable role in the growth cycle of bacteria. This article mainly reviews the latest research progress in the structure, secretory characteristics, and regulatory pathogenicity mechanism of bacterial OMVs, providing theoretical guidance for the in-depth study of bacterial pathogenicity mechanism and the development of new antibacterial strategies.

Key words: bacteria, outer membrane vesicles, structure, secretion characteristics, pathogenesis

中图分类号:

S852.61

高远集, 刘畅, 陈淼, 陈松彪, 张俊峰, 李静, 贾艳艳, 廖成水, 郭荣显, 丁轲, 余祖华, 尚珂. 细菌外膜囊泡结构、分泌特性及致病机制[J]. 畜牧兽医学报, 2024, 55(3): 971-983.

GAO Yuanji, LIU Chang, CHEN Miao, CHEN Songbiao, ZHANG Junfeng, LI Jing, JIA Yanyan, LIAO Chengshui, GUO Rongxian, DING Ke, YU Zuhua, SHANG Ke. Structure, Secretory Characteristics, and Pathogenic Mechanism of Bacterial Outer Membrane Vesicles[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 971-983.

参考文献

[1] 周舒扬, 张丕奇, 戴肖东, 等. 细菌外膜囊泡(OMV)研究进展[J]. 微生物学杂志, 2021, 41(6):83-89.
ZHOU S Y, ZHANG P Q, DAI X D, et al. Advances in bacterial Outer Membrane Vesicles (OMV)[J]. Journal of Microbiology, 2021, 41(6):83-89. (in Chinese)
[2] MACNAIR C R, TAN M W. The role of bacterial membrane vesicles in antibiotic resistance[J]. Ann New York Acad Sci, 2023, 1519:63-73.
[3] LEE E Y, CHOI D Y, KIM D K, et al. Gram-positive bacteria produce membrane vesicles:proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles[J]. Proteomics, 2009, 9(24):5425-5436.
[4] RIVERA J, CORDERO R J, NAKOUZI A S, et al. Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins[J]. Proc Natl Acad Sci U S A, 2010, 107(44):19002-19007.
[5] ELLIS T N, KUEHN M J. Virulence and immunomodulatory roles of bacterial outer membrane vesicles[J]. Microbiol Mol Biol Rev, 2010, 74(1):81-94.
[6] TOYOFUKU M, SCHILD S, KAPARAKIS-LIASKOS M, et al. Composition and functions of bacterial membrane vesicles[J]. Nat Rev Microbiol, 2023, 21(7):415-430.
[7] KULP A, KUEHN M J. Biological functions and biogenesis of secreted bacterial outer membrane vesicles[J]. Ann Rev Microbiol, 2010, 64:163-184.
[8] SCHWECHHEIMER C, KUEHN M J. Outer-membrane vesicles from Gram-negative bacteria:biogenesis and functions[J]. Nat Rev Microbiol, 2015, 13(10):605-619.
[9] TOYOFUKU M, NOMURA N, EBERL L. Types and origins of bacterial membrane vesicles[J]. Nat Rev Microbiol, 2019, 17(1):13-24.
[10] COSTA T R D, FELISBERTO-RODRIGUES C, MEIR A, et al. Secretion systems in Gram-negative bacteria:structural and mechanistic insights[J]. Nat Rev Microbiol, 2015, 13(6):343-359.
[11] GUERRERO-MANDUJANO A, HERNÁNDEZ-CORTEZ C, IBARRA J A, et al. The outer membrane vesicles:Secretion system type zero[J]. Traffic, 2017, 18(7):425-432.
[12] THAY B, DAMM A, KUFER T A, et al. Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1-and NOD2-dependent NF-κB activation[J]. Infect Immun, 2014, 82(10):4034-4046.
[13] BISHOP D G, WORK E. An extracellular glycolipid produced by Escherichia coli grown under lysine-limiting conditions[J]. Biochem J, 1965, 96(2):567-576.
[14] QING G, GONG N Q, CHEN X H, et al. Natural and engineered bacterial outer membrane vesicles[J]. Biophys Rep, 2019, 5(4):184-198.
[15] COMBO S, MENDES S, NIELSEN K M, et al. The discovery of the role of outer membrane vesicles against bacteria[J]. Biomedicines, 2022, 10(10):2399.
[16] KIM J Y, SUH J W, KANG J S, et al. Gram-negative bacteria's outer membrane vesicles[J]. Infect Chemother, 2023, 55(1):1-9.
[17] MCMILLAN H M, KUEHN M J. The extracellular vesicle generation paradox:a bacterial point of view[J]. EMBO J, 2021, 40(21):e108174.
[18] FURUYAMA N, SIRCILI M P. Outer membrane vesicles (OMVs) produced by gram-negative bacteria:structure, functions, biogenesis, and vaccine application[J]. BioMed Res Int, 2021, 2021:1490732.
[19] CHEN H Y, ZHOU M Y, ZENG Y T, et al. Recent advances in biomedical applications of bacterial outer membrane vesicles[J]. J Mater Chem B, 2022, 10(37):7384-7396.
[20] BAUMGARTEN T, SPERLING S, SEIFERT J, et al. Membrane vesicle formation as a multiple-stress response mechanism enhances Pseudomonas putida DOT-T1E cell surface hydrophobicity and biofilm formation[J]. Appl Environ Microbiol, 2012, 78(17):6217-6224.
[21] COLLINS S M, BROWN A C. Bacterial outer membrane vesicles as antibiotic delivery vehicles[J]. Front Immunol2021, 12:733064.
[22] 程谦, 吴疆, 王岱. 细菌外膜囊泡与抗生素相关的研究进展[J]. 中国抗生素杂志, 2019, 44(10):1119-1124.
CHENG Q, WU J, WANG D, et al. Advances in the relationship of bacterial outer-membrane vesicles and antibiotics[J]. Chinese Journal of Antibiotics, 2019, 44(10):1119-1124. (in Chinese)
[23] RUDNICKA M, NOSZCZYŃSKA M, MALICKA M, et al. Outer membrane vesicles as mediators of plant-bacterial interactions[J]. Front Microbiol, 2022, 13:902181.
[24] TURNER L, BITTO N J, STEER D L, et al. Helicobacter pylori Outer membrane vesicle size determines their mechanisms of host cell entry and protein content[J]. Front Immunol, 2018, 9:1466.
[25] JAN A T. Outer membrane vesicles (OMVs) of gram-negative bacteria:a perspective update[J]. Front Microbiol, 2017, 8:1053.
[26] WAI S N, LINDMARK B, SÖDERBLOM T, et al. Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin[J]. Cell, 2003, 115(1):25-35.
[27] FERRARI G, GARAGUSO I, ADU-BOBIE J, et al. Outer membrane vesicles from group B Neisseria meningitidis Δgna33 mutant:proteomic and immunological comparison with detergent-derived outer membrane vesicles[J]. Proteomics, 2006, 6(6):1856-1866.
[28] BEHRENS F, FUNK-HILSDORF T C, KUEBLER W M, et al. Bacterial membrane vesicles in pneumonia:from mediators of virulence to innovative vaccine candidates[J]. IntJ Mol Sci, 2021, 22(8):3858.
[29] JUODEIKIS R, CARDING S R. Outer membrane vesicles:biogenesis, functions, and issues[J]. Microbiol Mol Biol Rev, 2022, 86(4):e00032-22.
[30] ZINGL F G, KOHL P, CAKAR F, et al. Outer membrane vesiculation facilitates surface exchange and in vivo adaptation of vibrio cholerae[J]. Cell Host Microbe, 2020, 27(2):225-237. e8.
[31] ZINGL F G, THAPA H B, SCHARF M, et al. Outer membrane vesicles of Vibrio cholerae protect and deliver active cholera toxin to host cells via porin-dependent uptake[J]. mBio, 2021, 12(3):e0053421.
[32] NEVOT M, DERONCELÉ V, MESSNER P, et al. Characterization of outer membrane vesicles released by the psychrotolerant bacterium Pseudoalteromonas antarctica NF₃[J]. Environ Microbiol, 2006, 8(9):1523-1533.
[33] DELL'ANNUNZIATA F, FOLLIERO V, GIUGLIANO R, et al. Gene transfer potential of outer membrane vesicles of gram-negative bacteria[J]. Int J Mol Sci, 2021, 22(11):5985.
[34] JARZAB M, POSSELT G, MEISNER-KOBER N, et al. Helicobacter pylori-derived outer membrane vesicles (OMVs):role in bacterial pathogenesis?[J]. Microorganisms, 2020, 8(9):1328.
[35] 陈桥桥, 涂仕娟, 夏修文, 等. 细菌外膜囊泡发生机制的研究进展[J]. 泰山医学院学报, 2019, 40(12):980-982.
CHEN Q Q, TU S J, XIA X W, et al. Research progress on the mechanism of bacterial outer membrane vesicles[J]. Journal of Mount Taishan Medical College, 2019, 40(12):980-982. (in Chinese)
[36] AVILA-CALDERÓN E D, RUIZ-PALMA M D S, AGUILERA-ARREOLA M G, et al. Outer membrane vesicles of gram-negative bacteria:an outlook on biogenesis[J]. Front Microbiol, 2021, 12:557902.
[37] RENELLI M, MATIAS V, LO R Y, et al. DNA-containing membrane vesicles of Pseudomonas aeruginosa PAO1 and their genetic transformation potential[J]. Microbiology, 2004, 150(Pt 7):2161-2169.
[38] BAQUERO F. Environmental stress and evolvability in microbial systems[J]. Clinical Microbiology and Infection, 2009, 15(Suppl 1):5-10.
[39] TOUSSAINT A, CHANDLER M. Prokaryote genome fluidity:toward a system approach of the mobilome[M]//HELDEN J, TOUSSAINT A, THIEFFRY D. Bacterial Molecular Networks. New York:Springer, 2012:57-80.
[40] LI M, ZHOU H, YANG C, et al. Bacterial outer membrane vesicles as a platform for biomedical applications:An update[J]. J Control Release, 2020, 323:253-268.
[41] BEGIĆ M, JOSIĆ D. Biofilm formation and extracellular microvesicles-The way of foodborne pathogens toward resistance[J]. Electrophoresis, 2020, 41(20):1718-1739.
[42] HUANG Y K, NIEH M P, CHEN W, et al. Outer membrane vesicles (OMVs) enabled bio-applications:A critical review[J]. Biotechnol Bioeng, 2022, 119(1):34-47.
[43] MCBROOM A J, KUEHN M J. Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response[J]. Mol Microbiol, 2007, 63(2):545-558.
[44] SABRA W, LVNSDORF H, ZENG A P. Alterations in the formation of lipopolysaccharide and membrane vesicles on the surface of Pseudomonas aeruginosa PAO1 under oxygen stress conditions[J]. Microbiology (Reading), 2003, 149(Pt 10):2789-2795.
[45] KUEHN M J, KESTY N C. Bacterial outer membrane vesicles and the host-pathogen interaction[J]. Genes Dev, 2005, 19(22):2645-2655.
[46] MANNING A J, KUEHN M J. Contribution of bacterial outer membrane vesicles to innate bacterial defense[J]. BMC Microbiol, 2011, 11:258.
[47] HOSSEINI-GIV N, BASAS A, HICKS C, et al. Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer[J]. Front Cell Infect Microbiol, 2022, 12:962216.
[48] MASHBURN-WARREN L M, WHITELEY M. Special delivery:vesicle trafficking in prokaryotes[J]. Mol Microbiol, 2006, 61(4):839-846.
[49] DORWARD D W, GARON C F, JUDD R C. Export and intercellular transfer of DNA via membrane blebs of Neisseria gonorrhoeae[J]. J Bacteriol, 1989, 171(5):2499-2505.
[50] SJöSTRöM A E, SANDBLAD L, UHLIN B E, et al. Membrane vesicle-mediated release of bacterial RNA[J]. Sci Rep, 2015, 5:15329.
[51] CHEN J W, ZHANG H F, WANG S Q, et al. Inhibitors of bacterial extracellular vesicles[J]. Front Microbiol, 2022, 13:835058.
[52] MICOLI F, MACLENNAN C A. Outer membrane vesicle vaccines[J]. Seminars Immunol, 2020, 50:101433.
[53] MIRZAEI R, MOHAMMADZADEH R, ALIKHANI M Y, et al. The biofilm-associated bacterial infections unrelated to indwelling devices[J]. IUBMB life, 2020, 72(7):1271-1285.
[54] YONEZAWA H, OSAKI T, WOO T, et al. Analysis of outer membrane vesicle protein involved in biofilm formation of Helicobacter pylori[J]. Anaerobe, 2011, 17(6):388-390.
[55] DEO P, CHOW S H, HAY I D, et al. Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis[J]. PLoS Pathog, 2018, 14(3):e1006945.
[56] DAVID L, TAIEB F, PÉNARY M, et al. Outer membrane vesicles produced by pathogenic strains of Escherichia coli block autophagic flux and exacerbate inflammasome activation[J]. Autophagy, 2022, 18(12):2913-2925.
[57] LIEBERMAN L A. Outer membrane vesicles:A bacterial-derived vaccination system[J]. Front Microbiol, 2022, 13:1029146.
[58] WEYANT K B, OLOYEDE A, PAL S, et al. A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens[J]. Nat Commun, 2023, 14(1):464.
[59] 张蒙蒙, 王桂琴, 徐飞. 革兰阴性菌外膜囊泡及其作用机制的研究进展[J]. 中国兽医科学, 2021, 51(9):1182-1189.
ZHANG M M, WANG G Q, XU F. Research progress on outer membrane vesicles of gram-negative and its mechanism[J]. Chinese Veterinary Science, 2021, 51(9):1182-1189. (in Chinese)
[60] JALALIFAR S, MOROVATI KHAMSI H, HOSSEINI-FARD S R, et al. Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes[J]. Infect Agents Cancer, 2023, 18(1):3.
[61] TASHIRO Y, YAWATA Y, TOYOFUKU M, et al. Interspecies interaction between Pseudomonas aeruginosa and other microorganisms[J]. Microbes Environ, 2013, 28(1):13-24.
[62] BALHUIZEN M D, VELDHUIZEN E J A, HAAGSMAN H P. Outer membrane vesicle induction and isolation for vaccine development[J]. Front Microbiol, 2021, 12:629090.
[63] RICE K C, BAYLES K W. Molecular control of bacterial death and lysis[J]. Microbiol Mol Biol Rev, 2008, 72(1):85-109.
[64] KAPARAKIS-LIASKOS M, FERRERO R L. Immune modulation by bacterial outer membrane vesicles[J]. Nat Rev Immunol, 2015, 15(6):375-387.
[65] JAHROMI L P, FUHRMANN G. Bacterial extracellular vesicles:Understanding biology promotes applications as nanopharmaceuticals[J]. Adv Drug Deliv Rev, 2021, 173:125-140.
[66] ROSSI O, CITIULO F, MANCINI F. Outer membrane vesicles:moving within the intricate labyrinth of assays that can predict risks of reactogenicity in humans[J]. Human Vacc Immunotherapeut, 2021, 17(2):601-613.
[67] GILMORE W J, JOHNSTON E L, ZAVAN L, et al. Immunomodulatory roles and novel applications of bacterial membrane vesicles[J]. Mol Immunol, 2021, 134:72-85.
[68] SPENCER N, YERUVA L. Role of bacterial infections in extracellular vesicles release and impact on immune response[J]. Biomed J, 2021, 44(2):157-164.
[69] LIANG X, DAI N N, SHENG K L, et al. Gut bacterial extracellular vesicles:important players in regulating intestinal microenvironment[J]. Gut Microbes, 2022, 14(1):2134689.
[70] WANG S M, GUO J Y, BAI Y, et al. Bacterial outer membrane vesicles as a candidate tumor vaccine platform[J]. Front Immunol, 2022, 13:987419.
[71] DHITAL S, DEO P, STUART I, et al. Bacterial outer membrane vesicles and host cell death signaling[J]. Trends Microbiol, 2021, 29(12):1106-1116.
[72] CARUANA J C, WALPER S A. Bacterial membrane vesicles as mediators of microbe-microbe and microbe-host community interactions[J]. Front Microbiol, 2020, 11:432.
[73] SARTORIO M G, PARDUE E J, FELDMAN M F, et al. Bacterial outer membrane vesicles:from discovery to applications[J]. Ann Rev Microbiol, 2021, 75:609-630.
[74] ROSALES-REYES R, PÉREZ-LÓPEZ A, SÁNCHEZ-GÓMEZ C, et al. Salmonella infects B cells by macropinocytosis and formation of spacious phagosomes but does not induce pyroptosis in favor of its survival[J]. Microb Pathogen, 2012, 52(6):367-374.
[75] CZUCZMAN M A, FATTOUH R, VAN RIJN J M, et al. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread[J]. Nature, 2014, 509(7499):230-234.
[76] AMANO A, TAKEUCHI H, FURUTA N. Outer membrane vesicles function as offensive weapons in host-parasite interactions[J]. Microbes Infect, 2010, 12(11):791-798.
[77] 姚鹏程, 叶恭银. 网格蛋白介导的内吞作用机制[J]. 生命科学研究, 2003, 7(S1):22-25, 69.
YAO P C, YE G Y. The mechanism of clathrin-mediated endocytosis[J]. Life Science Research, 2003, 7(S1):22-25, 69. (in Chinese)
[78] O'DONOGHUE E J, KRACHLER A M. Mechanisms of outer membrane vesicle entry into host cells[J]. Cell Microbiol, 2016, 18(11):1508-1517.
[79] MULCAHY L A, PINK R C, CARTER D R. Routes and mechanisms of extracellular vesicle uptake[J]. J Extracell Vesicles, 2014, 3(1):24641.
[80] DEMUTH D R, JAMES D, KOWASHI Y, et al. Interaction of Actinobacillus actinomycetemcomitans outer membrane vesicles with HL60 cells does not require leukotoxin[J]. Cell Microbiol, 2003, 5(2):111-121.
[81] GALKA F, WAI S N, KUSCH H, et al. Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles[J]. Infect Immun, 2008, 76(5):1825-1836.
[82] PALOMINO R A Ñ, VANPOUILLE C, COSTANTINI P E, et al. Microbiota-host communications:bacterial extracellular vesicles as a common language[J]. PLoS Pathog, 2021, 17(5):e1009508.
[83] DEHINWAL R, COOLEY D, RAKOV A V, et al. Increased production of outer membrane vesicles by Salmonella interferes with complement-mediated innate immune attack[J]. mBio, 2021, 12(3):e0086921.
[84] GIORDANO N P, CIAN M B, DALEBROUX Z D. Outer membrane lipid secretion and the innate immune response to gram-negative bacteria[J]. Infect Immun, 2020, 88(7):e00920-19.
[85] SIMPSON B W, TRENT M S. Pushing the envelope:LPS modifications and their consequences[J]. Nat Rev Microbiol, 2019, 17(7):403-416.
[86] CHOI J, KIM Y K, HAN P L. Extracellular vesicles derived from Lactobacillus plantarum Increase BDNF expression in cultured hippocampal neurons and produce antidepressant-like effects in mice[J]. Exp Neurobiol, 2019, 28(2):158-171.
[87] FINETHY R, DOCKTERMAN J, KUTSCH M, et al. Dynamin-related irgm proteins modulate LPS-induced caspase-11 activation and septic shock[J]. EMBO Rep, 2020, 21(11):e50830.
[88] 尚珂. 家禽中多重耐药性沙门菌的传播和外膜囊泡疫苗的评价[D]. 全州:全北国立大学, 2021. (in English)
SHANG K. Transmission of multidrug-resistant (MDR) Salmonella Enterica and evaluation of outer membrane vesicle (OMV) vaccines in poultry[D]. Jeonju:Jeonbuk National University, 2021.

细菌外膜囊泡结构、分泌特性及致病机制

Structure, Secretory Characteristics, and Pathogenic Mechanism of Bacterial Outer Membrane Vesicles

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	宋科林, 闫尊强, 王鹏飞, 程文昊, 李杰, 白雅琴, 孙国虎, 滚双宝. 基于SNP芯片分析徽县青泥黑猪遗传多样性和遗传结构[J]. 畜牧兽医学报, 2024, 55(3): 995-1006.
[2]	陈姝宇, 朱雪蛟, 周金柱, 陶然, 张雪寒, 索朗斯珠, 贡嘎, 李彬. 鸟苷酸结合蛋白GBP1和GBP2抑制猪轮状病毒体外复制[J]. 畜牧兽医学报, 2024, 55(1): 245-257.
[3]	于秀菊, 张敏爱, 胡燕姣, 朱芷葳, 王海东, 杨丽华, 范阔海. 枯草芽孢杆菌细菌素的分离、表达及稳定性分析[J]. 畜牧兽医学报, 2024, 55(1): 323-333.
[4]	李珂, 王宇龙, 李栋, 史新娥, 杨公社, 于太永. 畜禽泛基因组研究进展[J]. 畜牧兽医学报, 2023, 54(9): 3595-3604.
[5]	何琪富, 高峰, 吴盛辉, 张涌, 权富生. 参与调节哺乳动物精子运动的离子通道研究进展[J]. 畜牧兽医学报, 2023, 54(7): 2708-2722.
[6]	王静琳, 刘阳光, 徐启隆, 陈朔, 邓在双, 程诗雨, 丁月云, 郑先瑞, 殷宗俊, 张晓东. 皖岳黑猪基因组遗传变异分析及特征SNPs挖掘[J]. 畜牧兽医学报, 2023, 54(7): 2783-2793.
[7]	张任豹, 周东辉, 周李生, 高霄霄, 柳楠, 贺建宁. 基于70 K SNP芯片分析济宁青山羊保种群体的遗传结构[J]. 畜牧兽医学报, 2023, 54(7): 2836-2847.
[8]	熊程坤, 张道亮, 杨悦, 丁红研, 赵杰, 李玉, 王希春, 冯士彬, 赵畅, 汤继顺, 吴金节. 芦丁对围产期湖羊瘤胃发酵、瘤胃菌群结构及抗氧化性能的影响[J]. 畜牧兽医学报, 2023, 54(7): 2898-2909.
[9]	米慧, 彭灿, 贺志雄, 谭支良. 基于流式细胞术分选绵羊分泌型IgA包裹的消化道细菌[J]. 畜牧兽医学报, 2023, 54(7): 2924-2931.
[10]	陈松彪, 尚珂, 杜付熙, 余祖华, 李静, 贾艳艳, 廖成水, 张春杰, 丁轲, 程相朝. 沙门菌VI型分泌系统组装、结构特征和分泌调控网络的研究进展[J]. 畜牧兽医学报, 2023, 54(6): 2252-2263.
[11]	毛鹏, 王志浩, 李建基, 崔璐莹, 朱国强, 孟霞, 董俊升, 王亨. 铁死亡在细菌性感染中的研究进展[J]. 畜牧兽医学报, 2023, 54(6): 2280-2287.
[12]	赵真坚, 王书杰, 陈栋, 姬祥, 申琦, 余杨, 崔晟頔, 王俊戈, 陈子旸, 唐国庆. 基于低深度全基因组测序分析内江猪群体结构和遗传多样性[J]. 畜牧兽医学报, 2023, 54(6): 2297-2307.
[13]	陶璇, 杨雪梅, 梁艳, 刘一辉, 汪勇, 孔繁晶, 雷云峰, 杨跃奎, 王言, 安瑞, 杨坤, 吕学斌, 何志平, 顾以韧. 基于SNP芯片的丫杈猪保种群体遗传结构研究[J]. 畜牧兽医学报, 2023, 54(6): 2308-2319.
[14]	龙熙, 陈力, 吴平先, 张廷焕, 潘红梅, 张亮, 王金勇, 郭宗义, 柴捷. 合川黑猪保种群遗传结构及选择信号分析[J]. 畜牧兽医学报, 2023, 54(5): 1854-1867.
[15]	马克岩, 韩金涛, 白雅琴, 李讨讨, 马友记. 基于简化基因组测序的永登七山羊遗传多样性分析[J]. 畜牧兽医学报, 2023, 54(5): 1939-1950.