鸟类Leptin及其受体的研究进展

doi:10.11843/j.issn.0366-6964.2015.11.001

摘要/Abstract

摘要：

自1998年首次报道从鸡的肝组织中克隆获得“鸡Leptin基因”以来，鸡Leptin基因序列的正确性以及Leptin在家禽中的存在性就一直备受争议。虽然家禽Leptin受体的存在被广泛证实，但对其功能的研究也由于内源性Leptin的缺乏而受到限制。随着后基因组学研究时代的到来，使得在更大范围、更深层次上探寻鸟类Leptin基因的存在与否成为可能。2014年，3个独立的实验室先后报道了部分野生鸟类Leptin基因的克隆和功能验证，将鸟类Leptin及其受体的研究又推向了新的高潮。本文综述了鸟类Leptin及其受体基因的结构特征、起源进化、组织分布及“生理功能”的最新研究进展。

Abstract:

The authenticity of the so-called “chicken Leptin gene” was questioned since it was first reported in 1998.Actually it is not sure whether the Leptin gene exists in poultry genome until now.Although Leptin receptor gene had been widely confirmed in poultry，its physiological functions were still ambiguous due to the lack of endogenous Leptin.With the coming of the post genome age，it’s possible to look into the Leptin gene matter of avian species in wide scale and great depth.In 2014，3 laboratories independently reported the cloning and functional verification of Leptin gene in some wild birds.The findings greatly stimulated research interests in avian Leptin and Leptin receptor.We reviewed the latest advances in structure characteristics，origin and evolution，tissue distribution and “physiological functions” of Leptin and Leptin receptor gene in avian.

中图分类号:

王丹丹，李艳敏，蒋瑞瑞，康相涛，刘小军. 鸟类Leptin及其受体的研究进展[J]. 畜牧兽医学报, 2015, 46(11): 1905-1915.

WANG Dan-dan，LI Yan-min，JIANG Rui-rui，KANG Xiang-tao，LIU Xiao-jun. Research Advances on Avian Leptin and Its Receptor[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(11): 1905-1915.

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